Macrocyclic compounds that inhibit MCL-1 protein


Ontology type: sgo:Patent     


Patent Info

DATE

2022-03-22T00:00

AUTHORS

BROWN SEAN P , LI YUNXIAO , HARRINGTON PAUL E , LANMAN BRIAN ALAN , LOW JONATHAN D , MINATTI ANA ELENA , MA VU VAN , LI KEXUE

ABSTRACT

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stenoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer. More... »

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