Nucleobase editors and uses thereof


Ontology type: sgo:Patent     


Patent Info

DATE

2022-01-04T00:00

AUTHORS

LIU DAVID R , KOMOR ALEXIS CHRISTINE , REES HOLLY A , KIM YONGJOO

ABSTRACT

Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing proteins or protein domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing proteins or domains, are provided. More... »

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