Rationally designed, synthetic antibody libraries and uses therefor


Ontology type: sgo:Patent     


Patent Info

DATE

2021-05-18T00:00

AUTHORS

VASQUEZ MAXIMILIANO , FELDHAUS MICHAEL , GERNGROSS TILLMAN U , WITTRUP K DANE

ABSTRACT

The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences. More... »

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