Targeted modification of rat genome


Ontology type: sgo:Patent     


Patent Info

DATE

2021-04-13T00:00

AUTHORS

LEE JEFFREY D , MUJICA ALEXANDER O , AUERBACH WOJTEK , LAI KA-MAN VENUS , VALENZUELA DAVID M , YANCOPOULOS GEORGE D

ABSTRACT

Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Compositions and methods for generating a genetically modified rat comprising one or more targeted genetic modifications in their germline are also provided. Compositions and methods are provided which comprise a genetically modified rat or rat cell comprising a targeted genetic modification in the rat interleukin-2 receptor gamma locus, the rat ApoE locus, the rat Rag2 locus, the rat Rag1 locus and/or the rat Rag2/Rag1 locus. The various methods and compositions provided herein allows for these modified loci to be transmitted through the germline. More... »

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