RNA-guided transcriptional regulation and methods of using the same for the treatment of back pain


Ontology type: sgo:Patent     


Patent Info

DATE

2021-03-23T00:00

AUTHORS

BOWLES ROBERT D , FARHANG NILOOFAR , STOVER JOSHUA , SETTON LORI , GUILAK FARSHID , GERSBACH CHARLES , BRUNGER JONATHAN

ABSTRACT

Described herein are compositions and methods for treatment and prevention of low back pain. The compositions include vectors comprising nucleotide sequences encoding one or more CRISPR-Cas system guide RNAs and a RNA-directed nuclease. The methods include modulating expression of a gene in a cell using said compositions, introducing a CRISPR-Cas system into a cell comprising one or more vectors comprising said compositions, inducing site-specific DNA cleavage in a cell, and treating a subject having lower back pain, and lower back pain caused by degenerative disc disease using the compositions disclosed herein. More... »

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