Anti-EphA4 antibody


Ontology type: sgo:Patent     


Patent Info

DATE

2021-03-16T00:00

AUTHORS

INOUE EIJI , YAMADA AKIO , KAWAKATSU TOMOMI , IMAI TOSHIO , DEGUCHI MAKI , NAKATANI AKI

ABSTRACT

Provided is an anti-EphA4 antibody that can bind to EphA4 and enhance the cleavage of EphA4, as well as a pharmaceutical composition comprising the antibody as the active ingredient. A mouse anti-EphA4 antibody that has binding affinity towards EphA4 and can enhance the cleavage of EphA4 was obtained, and the sequence of the complementarity-determining region (CDR) of the mouse anti-EphA4 antibody was identified. Subsequently, the anti-EphA4 antibody of interest was obtained by producing a humanized antibody of the mouse anti-EphA4 antibody. More... »

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