Methods and compositions for sequencing modified nucleic acids


Ontology type: sgo:Patent     


Patent Info

DATE

2020-03-17T00:00

AUTHORS

KORLACH JONAS , TURNER STEPHEN , CLARK TYSON A

ABSTRACT

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid. More... »

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