Compounds that inhibit Mcl-1 protein


Ontology type: sgo:Patent     


Patent Info

DATE

2019-12-10T00:00

AUTHORS

BROWN SEAN P , LI KEXUE , LI YUNXIAO , STEC MARKIAN M

ABSTRACT

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer. More... »

Related SciGraph Publications

  • 2008-12. BCL-2 family antagonists for cancer therapy in NATURE REVIEWS DRUG DISCOVERY
  • 2008-12-16. Mcl-1 is a potential therapeutic target in multiple types of cancer in CELLULAR AND MOLECULAR LIFE SCIENCES
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0305", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "BROWN SEAN P", 
            "type": "Person"
          }, 
          {
            "name": "LI KEXUE", 
            "type": "Person"
          }, 
          {
            "name": "LI YUNXIAO", 
            "type": "Person"
          }, 
          {
            "name": "STEC MARKIAN M", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrd2658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030857223", 
              "https://doi.org/10.1038/nrd2658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-008-8637-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023498818", 
              "https://doi.org/10.1007/s00018-008-8637-6"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12-10T00:00", 
        "description": "

    Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I,

    \n

    \"embedded
    \nor a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.\n

    ", "endDate": "2038-03-28", "id": "sg:patent.US-10500213-B2", "name": "Compounds that inhibit Mcl-1 protein", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.417886.4", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-10500213-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_19.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-10500213-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-10500213-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-10500213-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-10500213-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    46 TRIPLES      15 PREDICATES      18 URIs      9 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-10500213-B2 schema:about anzsrc-for:03
    2 anzsrc-for:0305
    3 schema:author Nb0ecc137ca014553bc32e88331bfb163
    4 schema:citation sg:pub.10.1007/s00018-008-8637-6
    5 sg:pub.10.1038/nrd2658
    6 schema:datePublished 2019-12-10T00:00
    7 schema:description <p id="p-0001" num="0000">Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I,</p> <p id="p-0002" num="0000"><chemistry id="CHEM-US-00001" num="00001"><img id="EMI-C00001" he="47.58mm" wi="71.37mm" file="US10500213-20191210-C00001.TIF" alt="embedded image" img-content="chem" img-format="tif" orientation="portrait" inline="no"/><attachments><attachment idref="CHEM-US-00001" attachment-type="cdx" file="US10500213-20191210-C00001.CDX"/><attachment idref="CHEM-US-00001" attachment-type="mol" file="US10500213-20191210-C00001.MOL"/></attachments></chemistry><br/> or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer. </p>
    8 schema:endDate 2038-03-28
    9 schema:name Compounds that inhibit Mcl-1 protein
    10 schema:recipient grid-institutes:grid.417886.4
    11 schema:sameAs https://app.dimensions.ai/details/patent/US-10500213-B2
    12 schema:sdDatePublished 2022-09-02T16:21
    13 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    14 schema:sdPublisher N428b1c363978417d9ea2cb1e1458c4e5
    15 sgo:license sg:explorer/license/
    16 sgo:sdDataset patents
    17 rdf:type sgo:Patent
    18 N056ea0c6babd4ff9ba6174d044986e02 rdf:first N452baa47f4c84a43bba6942077950805
    19 rdf:rest rdf:nil
    20 N112de2108e094106ba270e465e793076 rdf:first Nacd1225dddc24b7eb43c4c344ae2a625
    21 rdf:rest Nf83efc3e52084055af8cd8b4b50cbe0b
    22 N3a71d725006d4775aaaf8d35fa5ba8f3 schema:name LI YUNXIAO
    23 rdf:type schema:Person
    24 N428b1c363978417d9ea2cb1e1458c4e5 schema:name Springer Nature - SN SciGraph project
    25 rdf:type schema:Organization
    26 N452baa47f4c84a43bba6942077950805 schema:name STEC MARKIAN M
    27 rdf:type schema:Person
    28 N5a6905bf409543d9aa5e8402dc8b1878 schema:name BROWN SEAN P
    29 rdf:type schema:Person
    30 Nacd1225dddc24b7eb43c4c344ae2a625 schema:name LI KEXUE
    31 rdf:type schema:Person
    32 Nb0ecc137ca014553bc32e88331bfb163 rdf:first N5a6905bf409543d9aa5e8402dc8b1878
    33 rdf:rest N112de2108e094106ba270e465e793076
    34 Nf83efc3e52084055af8cd8b4b50cbe0b rdf:first N3a71d725006d4775aaaf8d35fa5ba8f3
    35 rdf:rest N056ea0c6babd4ff9ba6174d044986e02
    36 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    37 rdf:type schema:DefinedTerm
    38 anzsrc-for:0305 schema:inDefinedTermSet anzsrc-for:
    39 rdf:type schema:DefinedTerm
    40 sg:pub.10.1007/s00018-008-8637-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023498818
    41 https://doi.org/10.1007/s00018-008-8637-6
    42 rdf:type schema:CreativeWork
    43 sg:pub.10.1038/nrd2658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030857223
    44 https://doi.org/10.1038/nrd2658
    45 rdf:type schema:CreativeWork
    46 grid-institutes:grid.417886.4 schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...