Targeted modification of rat genome


Ontology type: sgo:Patent     


Patent Info

DATE

2019-08-20T00:00

AUTHORS

LEE JEFFREY D , MUJICA ALEXANDER O , AUERBACH WOJTEK , LAI KA-MAN VENUS , VALENZUELA DAVID M , YANCOPOULOS GEORGE D

ABSTRACT

Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Compositions and methods for generating a genetically modified rat comprising one or more targeted genetic modifications in their germline are also provided. Compositions and methods are provided which comprise a genetically modified rat or rat cell comprising a targeted genetic modification in the rat interleukin-2 receptor gamma locus, the rat ApoE locus, the rat Rag2 locus, the rat Rag1 locus and/or the rat Rag2/Rag1 locus. The various methods and compositions provided herein allows for these modified loci to be transmitted through the germline. More... »

Related SciGraph Publications

  • 2011-10-15. Derivation of rat embryonic stem cells and generation of protease-activated receptor-2 knockout rats in TRANSGENIC RESEARCH
  • 2016-04-20. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage in NATURE
  • 2014-10-14. Strategies for gene disruption in Drosophila in CELL & BIOSCIENCE
  • 2014-12-10. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex in NATURE
  • 2013-10-24. Genome engineering using the CRISPR-Cas9 system in NATURE PROTOCOLS
  • 2011-07-17. High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases in NATURE METHODS
  • 2008-06-29. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2015-03-23. Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining in NATURE BIOTECHNOLOGY
  • 2014-08-03. Generation of fertile and fecund F0 XY female mice from XY ES cells in TRANSGENIC RESEARCH
  • 2015-03-24. Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells in NATURE BIOTECHNOLOGY
  • 2015-04-01. In vivo genome editing using Staphylococcus aureus Cas9 in NATURE
  • 2013-08-08. Targeted genome modification of crop plants using a CRISPR-Cas system in NATURE BIOTECHNOLOGY
  • 2013-08-01. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering in NATURE BIOTECHNOLOGY
  • 2016-05-09. Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes in NATURE BIOTECHNOLOGY
  • 2016-05-02. DNA-guided genome editing using the Natronobacterium gregoryi Argonaute in NATURE BIOTECHNOLOGY
  • 2013-05-12. TALEN-mediated editing of the mouse Y chromosome in NATURE BIOTECHNOLOGY
  • 2011-05-26. Generating gene knockout rats by homologous recombination in embryonic stem cells in NATURE PROTOCOLS
  • 2015-07-13. Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach in NATURE METHODS
  • 2009-04-12. Enzymatic assembly of DNA molecules up to several hundred kilobases in NATURE METHODS
  • 2014-03-27. TALEN-mediated editing of endogenous T-cell receptors facilitates efficient reprogramming of T lymphocytes by lentiviral gene transfer in GENE THERAPY
  • 2018-07-16. Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements in NATURE BIOTECHNOLOGY
  • 2008-09-11. Progress and prospects: Zinc-finger nucleases as gene therapy agents in GENE THERAPY
  • 2013-08-08. Heritable gene targeting in the mouse and rat using a CRISPR-Cas system in NATURE BIOTECHNOLOGY
  • 2006-12-24. F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses in NATURE BIOTECHNOLOGY
  • 2014-04-08. Gene editing at CRISPR speed in NATURE BIOTECHNOLOGY
  • 2011-06-14. The heterogeneity and dynamic equilibrium of rat embryonic stem cells in CELL RESEARCH
  • 2016-04-25. CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes in NATURE BIOTECHNOLOGY
  • 2010-08-11. Production of p53 gene knockout rats by homologous recombination in embryonic stem cells in NATURE
  • 2014-09-25. CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos in NATURE PROTOCOLS
  • 2008-04-28. Progress and prospects in rat genetics: a community view in NATURE GENETICS
  • 2013-03-26. Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos in CELL RESEARCH
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "LEE JEFFREY D", 
            "type": "Person"
          }, 
          {
            "name": "MUJICA ALEXANDER O", 
            "type": "Person"
          }, 
          {
            "name": "AUERBACH WOJTEK", 
            "type": "Person"
          }, 
          {
            "name": "LAI KA-MAN VENUS", 
            "type": "Person"
          }, 
          {
            "name": "VALENZUELA DAVID M", 
            "type": "Person"
          }, 
          {
            "name": "YANCOPOULOS GEORGE D", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nbt1410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048577624", 
              "https://doi.org/10.1038/nbt1410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.4192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105601158", 
              "https://doi.org/10.1038/nbt.4192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046255083", 
              "https://doi.org/10.1038/nmeth.1653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034818059", 
              "https://doi.org/10.1038/nbt.3536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015832660", 
              "https://doi.org/10.1038/nbt.2595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041659759", 
              "https://doi.org/10.1038/nbt.2675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11248-014-9815-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009945616", 
              "https://doi.org/10.1007/s11248-014-9815-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008380407", 
              "https://doi.org/10.1038/nbt.2661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2011.98", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030117969", 
              "https://doi.org/10.1038/cr.2011.98"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019168198", 
              "https://doi.org/10.1038/nature14299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016534425", 
              "https://doi.org/10.1038/nprot.2013.143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017538548", 
              "https://doi.org/10.1038/nbt.3190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047211077", 
              "https://doi.org/10.1038/nbt.3547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2045-3701-4-63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039783661", 
              "https://doi.org/10.1186/2045-3701-4-63"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2014.171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046392021", 
              "https://doi.org/10.1038/nprot.2014.171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048954459", 
              "https://doi.org/10.1038/nature14136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2011.338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048929714", 
              "https://doi.org/10.1038/nprot.2011.338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11248-011-9564-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007672047", 
              "https://doi.org/10.1007/s11248-011-9564-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001687622", 
              "https://doi.org/10.1038/nbt.2863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040405189", 
              "https://doi.org/10.1038/nmeth.1318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2650", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040481921", 
              "https://doi.org/10.1038/nbt.2650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3473", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051395827", 
              "https://doi.org/10.1038/nmeth.3473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011225906", 
              "https://doi.org/10.1038/ng.147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005821114", 
              "https://doi.org/10.1038/nbt.3567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003961169", 
              "https://doi.org/10.1038/nature09368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2013.45", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006654084", 
              "https://doi.org/10.1038/cr.2013.45"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature17946", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009172001", 
              "https://doi.org/10.1038/nature17946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/gt.2014.26", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014495489", 
              "https://doi.org/10.1038/gt.2014.26"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015062044", 
              "https://doi.org/10.1038/nbt1263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/gt.2008.145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045636817", 
              "https://doi.org/10.1038/gt.2008.145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008895789", 
              "https://doi.org/10.1038/nbt.3198"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-08-20T00:00", 
        "description": "

    Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Compositions and methods for generating a genetically modified rat comprising one or more targeted genetic modifications in their germline are also provided. Compositions and methods are provided which comprise a genetically modified rat or rat cell comprising a targeted genetic modification in the rat interleukin-2 receptor gamma locus, the rat ApoE locus, the rat Rag2 locus, the rat Rag1 locus and/or the rat Rag2/Rag1 locus. The various methods and compositions provided herein allows for these modified loci to be transmitted through the germline.

    ", "endDate": "2034-05-26", "id": "sg:patent.US-10385359-B2", "name": "Targeted modification of rat genome", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.418961.3", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-10385359-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_46.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-10385359-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-10385359-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-10385359-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-10385359-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    170 TRIPLES      15 PREDICATES      47 URIs      9 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-10385359-B2 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N78dfe2f09e9441b39eb0f499a1550317
    4 schema:citation sg:pub.10.1007/s11248-011-9564-0
    5 sg:pub.10.1007/s11248-014-9815-y
    6 sg:pub.10.1038/cr.2011.98
    7 sg:pub.10.1038/cr.2013.45
    8 sg:pub.10.1038/gt.2008.145
    9 sg:pub.10.1038/gt.2014.26
    10 sg:pub.10.1038/nature09368
    11 sg:pub.10.1038/nature14136
    12 sg:pub.10.1038/nature14299
    13 sg:pub.10.1038/nature17946
    14 sg:pub.10.1038/nbt.2595
    15 sg:pub.10.1038/nbt.2650
    16 sg:pub.10.1038/nbt.2661
    17 sg:pub.10.1038/nbt.2675
    18 sg:pub.10.1038/nbt.2863
    19 sg:pub.10.1038/nbt.3190
    20 sg:pub.10.1038/nbt.3198
    21 sg:pub.10.1038/nbt.3536
    22 sg:pub.10.1038/nbt.3547
    23 sg:pub.10.1038/nbt.3567
    24 sg:pub.10.1038/nbt.4192
    25 sg:pub.10.1038/nbt1263
    26 sg:pub.10.1038/nbt1410
    27 sg:pub.10.1038/ng.147
    28 sg:pub.10.1038/nmeth.1318
    29 sg:pub.10.1038/nmeth.1653
    30 sg:pub.10.1038/nmeth.3473
    31 sg:pub.10.1038/nprot.2011.338
    32 sg:pub.10.1038/nprot.2013.143
    33 sg:pub.10.1038/nprot.2014.171
    34 sg:pub.10.1186/2045-3701-4-63
    35 schema:datePublished 2019-08-20T00:00
    36 schema:description <p>Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Compositions and methods for generating a genetically modified rat comprising one or more targeted genetic modifications in their germline are also provided. Compositions and methods are provided which comprise a genetically modified rat or rat cell comprising a targeted genetic modification in the rat interleukin-2 receptor gamma locus, the rat ApoE locus, the rat Rag2 locus, the rat Rag1 locus and/or the rat Rag2/Rag1 locus. The various methods and compositions provided herein allows for these modified loci to be transmitted through the germline.</p>
    37 schema:endDate 2034-05-26
    38 schema:name Targeted modification of rat genome
    39 schema:recipient grid-institutes:grid.418961.3
    40 schema:sameAs https://app.dimensions.ai/details/patent/US-10385359-B2
    41 schema:sdDatePublished 2022-09-02T16:21
    42 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    43 schema:sdPublisher Neb486457701d4c05b57fc601b6c386e6
    44 sgo:license sg:explorer/license/
    45 sgo:sdDataset patents
    46 rdf:type sgo:Patent
    47 N00968b93fd0946f9b7945890caf3426c schema:name MUJICA ALEXANDER O
    48 rdf:type schema:Person
    49 N02c18ce5c7fc4ee0aa3524bcfdbb4303 schema:name LEE JEFFREY D
    50 rdf:type schema:Person
    51 N13ebde6a811344d89ef056de553bd55a rdf:first Nedc072c5364246439e30a3b314771f18
    52 rdf:rest N3582f4bb4563412dba23bd7e0b099fa0
    53 N3582f4bb4563412dba23bd7e0b099fa0 rdf:first N8e8b4d5b623f4ee09b2955e6af8fe3fe
    54 rdf:rest N802fa2a32fec4eb2816a11a6f76ebd66
    55 N78dfe2f09e9441b39eb0f499a1550317 rdf:first N02c18ce5c7fc4ee0aa3524bcfdbb4303
    56 rdf:rest Nff44cefa68ba49b9b17d553a2c515c23
    57 N802fa2a32fec4eb2816a11a6f76ebd66 rdf:first Nbe00d7f195ea42d7bf0030cf50d75007
    58 rdf:rest Nc2719397c9bb425da17237f85eb0d5eb
    59 N8e8b4d5b623f4ee09b2955e6af8fe3fe schema:name LAI KA-MAN VENUS
    60 rdf:type schema:Person
    61 Na55f0484fdca441bb5e156bfabc823b8 schema:name YANCOPOULOS GEORGE D
    62 rdf:type schema:Person
    63 Nbe00d7f195ea42d7bf0030cf50d75007 schema:name VALENZUELA DAVID M
    64 rdf:type schema:Person
    65 Nc2719397c9bb425da17237f85eb0d5eb rdf:first Na55f0484fdca441bb5e156bfabc823b8
    66 rdf:rest rdf:nil
    67 Neb486457701d4c05b57fc601b6c386e6 schema:name Springer Nature - SN SciGraph project
    68 rdf:type schema:Organization
    69 Nedc072c5364246439e30a3b314771f18 schema:name AUERBACH WOJTEK
    70 rdf:type schema:Person
    71 Nff44cefa68ba49b9b17d553a2c515c23 rdf:first N00968b93fd0946f9b7945890caf3426c
    72 rdf:rest N13ebde6a811344d89ef056de553bd55a
    73 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    74 rdf:type schema:DefinedTerm
    75 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    76 rdf:type schema:DefinedTerm
    77 sg:pub.10.1007/s11248-011-9564-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007672047
    78 https://doi.org/10.1007/s11248-011-9564-0
    79 rdf:type schema:CreativeWork
    80 sg:pub.10.1007/s11248-014-9815-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1009945616
    81 https://doi.org/10.1007/s11248-014-9815-y
    82 rdf:type schema:CreativeWork
    83 sg:pub.10.1038/cr.2011.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030117969
    84 https://doi.org/10.1038/cr.2011.98
    85 rdf:type schema:CreativeWork
    86 sg:pub.10.1038/cr.2013.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006654084
    87 https://doi.org/10.1038/cr.2013.45
    88 rdf:type schema:CreativeWork
    89 sg:pub.10.1038/gt.2008.145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045636817
    90 https://doi.org/10.1038/gt.2008.145
    91 rdf:type schema:CreativeWork
    92 sg:pub.10.1038/gt.2014.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014495489
    93 https://doi.org/10.1038/gt.2014.26
    94 rdf:type schema:CreativeWork
    95 sg:pub.10.1038/nature09368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003961169
    96 https://doi.org/10.1038/nature09368
    97 rdf:type schema:CreativeWork
    98 sg:pub.10.1038/nature14136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048954459
    99 https://doi.org/10.1038/nature14136
    100 rdf:type schema:CreativeWork
    101 sg:pub.10.1038/nature14299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019168198
    102 https://doi.org/10.1038/nature14299
    103 rdf:type schema:CreativeWork
    104 sg:pub.10.1038/nature17946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009172001
    105 https://doi.org/10.1038/nature17946
    106 rdf:type schema:CreativeWork
    107 sg:pub.10.1038/nbt.2595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015832660
    108 https://doi.org/10.1038/nbt.2595
    109 rdf:type schema:CreativeWork
    110 sg:pub.10.1038/nbt.2650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040481921
    111 https://doi.org/10.1038/nbt.2650
    112 rdf:type schema:CreativeWork
    113 sg:pub.10.1038/nbt.2661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008380407
    114 https://doi.org/10.1038/nbt.2661
    115 rdf:type schema:CreativeWork
    116 sg:pub.10.1038/nbt.2675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041659759
    117 https://doi.org/10.1038/nbt.2675
    118 rdf:type schema:CreativeWork
    119 sg:pub.10.1038/nbt.2863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001687622
    120 https://doi.org/10.1038/nbt.2863
    121 rdf:type schema:CreativeWork
    122 sg:pub.10.1038/nbt.3190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017538548
    123 https://doi.org/10.1038/nbt.3190
    124 rdf:type schema:CreativeWork
    125 sg:pub.10.1038/nbt.3198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008895789
    126 https://doi.org/10.1038/nbt.3198
    127 rdf:type schema:CreativeWork
    128 sg:pub.10.1038/nbt.3536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034818059
    129 https://doi.org/10.1038/nbt.3536
    130 rdf:type schema:CreativeWork
    131 sg:pub.10.1038/nbt.3547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047211077
    132 https://doi.org/10.1038/nbt.3547
    133 rdf:type schema:CreativeWork
    134 sg:pub.10.1038/nbt.3567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005821114
    135 https://doi.org/10.1038/nbt.3567
    136 rdf:type schema:CreativeWork
    137 sg:pub.10.1038/nbt.4192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105601158
    138 https://doi.org/10.1038/nbt.4192
    139 rdf:type schema:CreativeWork
    140 sg:pub.10.1038/nbt1263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015062044
    141 https://doi.org/10.1038/nbt1263
    142 rdf:type schema:CreativeWork
    143 sg:pub.10.1038/nbt1410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048577624
    144 https://doi.org/10.1038/nbt1410
    145 rdf:type schema:CreativeWork
    146 sg:pub.10.1038/ng.147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011225906
    147 https://doi.org/10.1038/ng.147
    148 rdf:type schema:CreativeWork
    149 sg:pub.10.1038/nmeth.1318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040405189
    150 https://doi.org/10.1038/nmeth.1318
    151 rdf:type schema:CreativeWork
    152 sg:pub.10.1038/nmeth.1653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046255083
    153 https://doi.org/10.1038/nmeth.1653
    154 rdf:type schema:CreativeWork
    155 sg:pub.10.1038/nmeth.3473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051395827
    156 https://doi.org/10.1038/nmeth.3473
    157 rdf:type schema:CreativeWork
    158 sg:pub.10.1038/nprot.2011.338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048929714
    159 https://doi.org/10.1038/nprot.2011.338
    160 rdf:type schema:CreativeWork
    161 sg:pub.10.1038/nprot.2013.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016534425
    162 https://doi.org/10.1038/nprot.2013.143
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1038/nprot.2014.171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046392021
    165 https://doi.org/10.1038/nprot.2014.171
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1186/2045-3701-4-63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039783661
    168 https://doi.org/10.1186/2045-3701-4-63
    169 rdf:type schema:CreativeWork
    170 grid-institutes:grid.418961.3 schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...