Reduced toxicity molecular conjugates of anti-fungal agents


Ontology type: sgo:Patent     


Patent Info

DATE

2019-06-18T00:00

AUTHORS

REGEN STEVEN L , JANOUT VACLAV , YU YUMING

ABSTRACT

Compositions, compounds and methods are described for addressing both toxicity of membrane disruptive anti-microbial agents as well as poor transport of such agents across the blood-brain-barrier (BBB) via the use of molecular appendages including one or more facial amphiphiles. These molecules have in vitro anti-fungal activity that is very similar to that of the native drug but with hemolytic activity and toxicity towards mammalian cells that is greatly reduced. More... »

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