Rationally designed, synthetic antibody libraries and uses therefor


Ontology type: sgo:Patent     


Patent Info

DATE

2019-01-29T00:00

AUTHORS

VASQUEZ MAXIMILIANO , FELDHAUS MICHAEL , GERNGROSS TILLMAN U , WITTRUP K DANE

ABSTRACT

The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences. More... »

Related SciGraph Publications

  • 1989-10. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli in NATURE
  • 1988-03. Reshaping human antibodies for therapy in NATURE
  • 1996-03. Organ targeting In vivo using phage display peptide libraries in NATURE
  • 2005-10-06. Engineering novel binding proteins from nonimmunoglobulin domains in NATURE BIOTECHNOLOGY
  • 1981-04. Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes in NATURE
  • 2005-09-01. Engineered antibody fragments and the rise of single domains in NATURE BIOTECHNOLOGY
  • 1991-06. Humanized antibodies for therapy in NATURE
  • 1992-07-01. By–Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling in BIO/TECHNOLOGY
  • 1990-12. Phage antibodies: filamentous phage displaying antibody variable domains in NATURE
  • 2008-01-10. Evolutionary dynamics of the immunoglobulin heavy chain variable region genes in vertebrates in IMMUNOGENETICS
  • 2005-11-20. Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains in NATURE BIOTECHNOLOGY
  • 2000-01. Exploiting recombination in single bacteria to make large phage antibody libraries in NATURE BIOTECHNOLOGY
  • 2000-12. Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display in NATURE BIOTECHNOLOGY
  • 1993-12. Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack in NATURE
  • 1989-07. A novel genetic system to detect protein–protein interactions in NATURE
  • 2000-07. Directed evolution of a stable scaffold for T-cell receptor engineering in NATURE BIOTECHNOLOGY
  • 2000-07. Construction of an engineered yeast with glucose-inducible emission of green fluorescence from the cell surface in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1989-12. Conformations of immunoglobulin hypervariable regions in NATURE
  • 2002-06-14. The Rhesus monkey immunoglobulin IGHD and IGHJ germline repertoire in IMMUNOGENETICS
  • 1975-08. Continuous cultures of fused cells secreting antibody of predefined specificity in NATURE
  • 2008-08-20. The reported germline repertoire of human immunoglobulin kappa chain genes is relatively complete and accurate in IMMUNOGENETICS
  • 2012-01-09. The discovery and development of belimumab: the anti-BLyS–lupus connection in NATURE BIOTECHNOLOGY
  • 2006-05-14. A microengraving method for rapid selection of single cells producing antigen-specific antibodies in NATURE BIOTECHNOLOGY
  • 1997-06. Yeast surface display for screening combinatorial polypeptide libraries in NATURE BIOTECHNOLOGY
  • 1997-07. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens in NATURE GENETICS
  • 1991-08. Making antibody fragments using phage display libraries in NATURE
  • 1991-01. Man-made antibodies in NATURE
  • 2001-11. Development of novel whole-cell immunoadsorbents by yeast surface display of the IgG-binding domain in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1997-01-01. Display of heterologous proteins on the surface of microorganisms: From the screening of combinatorial libraries to live recombinant vaccines in NATURE BIOTECHNOLOGY
  • 2006-01-10. Reconsidering the human immunoglobulin heavy-chain locus: in IMMUNOGENETICS
  • 2007-05-01. Isolation of engineered, full-length antibodies from libraries expressed in Escherichia coli in NATURE BIOTECHNOLOGY
  • 2005-09-07. Monoclonal antibody therapy of cancer in NATURE BIOTECHNOLOGY
  • 1985-04-01. The synthesis and in vivo assembly of functional antibodies in yeast in NATURE
  • 1986-05. Replacing the complementarity-determining regions in a human antibody with those from a mouse in NATURE
  • 2000-02. A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae in NATURE
  • 2010-07-20. Integrated Mimicry of B Cell Antibody Mutagenesis Using Yeast Homologous Recombination in MOLECULAR BIOTECHNOLOGY
  • 1988-10. Immunoglobulin JH rearrangement in a T-cell line reflects fusion to the DH locus at a sequence lacking the nonamer recognition signal in IMMUNOGENETICS
  • 1998-08. Directed selection of MIP-1α neutralizing CCR5 antibodies from a phage display human antibody library in NATURE BIOTECHNOLOGY
  • 2005-02-20. Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity in NATURE BIOTECHNOLOGY
  • 1991-06-01. Antibody Engineering: Advances From the Use of Escherichia coli Expression Systems in BIO/TECHNOLOGY
  • 2011-03-18. Complex Pharmacokinetics of a Humanized Antibody Against Human Amyloid Beta Peptide, Anti-Abeta Ab2, in Nonclinical Species in PHARMACEUTICAL RESEARCH
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "VASQUEZ MAXIMILIANO", 
            "type": "Person"
          }, 
          {
            "name": "FELDHAUS MICHAEL", 
            "type": "Person"
          }, 
          {
            "name": "GERNGROSS TILLMAN U", 
            "type": "Person"
          }, 
          {
            "name": "WITTRUP K DANE", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00251-007-0270-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001224932", 
              "https://doi.org/10.1007/s00251-007-0270-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015036233", 
              "https://doi.org/10.1038/nbt1296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0691-545", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014209564", 
              "https://doi.org/10.1038/nbt0691-545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00251-002-0468-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010656782", 
              "https://doi.org/10.1007/s00251-002-0468-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/314446a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003708008", 
              "https://doi.org/10.1038/314446a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35001009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035773549", 
              "https://doi.org/10.1038/35001009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/349293a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027225150", 
              "https://doi.org/10.1038/349293a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003971085", 
              "https://doi.org/10.1038/nbt.2076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/290565a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020825524", 
              "https://doi.org/10.1038/290565a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0697-553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017819354", 
              "https://doi.org/10.1038/nbt0697-553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00251-005-0062-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019809538", 
              "https://doi.org/10.1007/s00251-005-0062-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0792-779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007019873", 
              "https://doi.org/10.1038/nbt0792-779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12033-010-9312-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015128428", 
              "https://doi.org/10.1007/s12033-010-9312-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/332323a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016704652", 
              "https://doi.org/10.1038/332323a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005554229", 
              "https://doi.org/10.1038/nbt1210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045244248", 
              "https://doi.org/10.1038/nbt1166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/71958", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007437849", 
              "https://doi.org/10.1038/71958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041511297", 
              "https://doi.org/10.1038/77325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/380364a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004838712", 
              "https://doi.org/10.1038/380364a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/352624a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021945431", 
              "https://doi.org/10.1038/352624a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/340245a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028860985", 
              "https://doi.org/10.1038/340245a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/366469a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000948603", 
              "https://doi.org/10.1038/366469a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-011-0405-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012968826", 
              "https://doi.org/10.1007/s11095-011-0405-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0197-29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052564290", 
              "https://doi.org/10.1038/nbt0197-29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/342877a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003340695", 
              "https://doi.org/10.1038/342877a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/348552a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009781465", 
              "https://doi.org/10.1038/348552a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/321522a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007617918", 
              "https://doi.org/10.1038/321522a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018849649", 
              "https://doi.org/10.1038/nbt1142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/82407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011912944", 
              "https://doi.org/10.1038/82407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/341544a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030400388", 
              "https://doi.org/10.1038/341544a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002539900307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037271551", 
              "https://doi.org/10.1007/s002539900307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00345502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016618982", 
              "https://doi.org/10.1007/bf00345502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002530100802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003402614", 
              "https://doi.org/10.1007/s002530100802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045032676", 
              "https://doi.org/10.1038/nbt1127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0797-277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007071524", 
              "https://doi.org/10.1038/ng0797-277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035568197", 
              "https://doi.org/10.1038/nbt1137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005964635", 
              "https://doi.org/10.1038/nbt1067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/351501a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025716632", 
              "https://doi.org/10.1038/351501a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00251-008-0325-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009496018", 
              "https://doi.org/10.1007/s00251-008-0325-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/256495a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001387921", 
              "https://doi.org/10.1038/256495a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0898-778", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037590787", 
              "https://doi.org/10.1038/nbt0898-778"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-01-29T00:00", 
        "description": "

    The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.

    ", "endDate": "2030-08-11", "id": "sg:patent.US-10189894-B2", "name": "Rationally designed, synthetic antibody libraries and uses therefor", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.508569.7", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-10189894-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_10.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-10189894-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-10189894-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-10189894-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-10189894-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    202 TRIPLES      15 PREDICATES      57 URIs      9 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-10189894-B2 schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author N0ea1fc51e18646e3a9875b235dfbe4ce
    4 schema:citation sg:pub.10.1007/bf00345502
    5 sg:pub.10.1007/s00251-002-0468-2
    6 sg:pub.10.1007/s00251-005-0062-5
    7 sg:pub.10.1007/s00251-007-0270-2
    8 sg:pub.10.1007/s00251-008-0325-z
    9 sg:pub.10.1007/s002530100802
    10 sg:pub.10.1007/s002539900307
    11 sg:pub.10.1007/s11095-011-0405-x
    12 sg:pub.10.1007/s12033-010-9312-3
    13 sg:pub.10.1038/256495a0
    14 sg:pub.10.1038/290565a0
    15 sg:pub.10.1038/314446a0
    16 sg:pub.10.1038/321522a0
    17 sg:pub.10.1038/332323a0
    18 sg:pub.10.1038/340245a0
    19 sg:pub.10.1038/341544a0
    20 sg:pub.10.1038/342877a0
    21 sg:pub.10.1038/348552a0
    22 sg:pub.10.1038/349293a0
    23 sg:pub.10.1038/35001009
    24 sg:pub.10.1038/351501a0
    25 sg:pub.10.1038/352624a0
    26 sg:pub.10.1038/366469a0
    27 sg:pub.10.1038/380364a0
    28 sg:pub.10.1038/71958
    29 sg:pub.10.1038/77325
    30 sg:pub.10.1038/82407
    31 sg:pub.10.1038/nbt.2076
    32 sg:pub.10.1038/nbt0197-29
    33 sg:pub.10.1038/nbt0691-545
    34 sg:pub.10.1038/nbt0697-553
    35 sg:pub.10.1038/nbt0792-779
    36 sg:pub.10.1038/nbt0898-778
    37 sg:pub.10.1038/nbt1067
    38 sg:pub.10.1038/nbt1127
    39 sg:pub.10.1038/nbt1137
    40 sg:pub.10.1038/nbt1142
    41 sg:pub.10.1038/nbt1166
    42 sg:pub.10.1038/nbt1210
    43 sg:pub.10.1038/nbt1296
    44 sg:pub.10.1038/ng0797-277
    45 schema:datePublished 2019-01-29T00:00
    46 schema:description <p id="p-0001" num="0000">The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.</p>
    47 schema:endDate 2030-08-11
    48 schema:name Rationally designed, synthetic antibody libraries and uses therefor
    49 schema:recipient grid-institutes:grid.508569.7
    50 schema:sameAs https://app.dimensions.ai/details/patent/US-10189894-B2
    51 schema:sdDatePublished 2022-09-02T16:21
    52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    53 schema:sdPublisher N6b873a67fee6432b91ce1b21e285a867
    54 sgo:license sg:explorer/license/
    55 sgo:sdDataset patents
    56 rdf:type sgo:Patent
    57 N0a4e7cf1487744baa13c56e2d34b6353 rdf:first Ndcc7fa89a5d5443293216eea76e7491e
    58 rdf:rest rdf:nil
    59 N0ea1fc51e18646e3a9875b235dfbe4ce rdf:first N49720670a2d445e0b1ee2cd600a0eb86
    60 rdf:rest Ne8334220759d45ac93d39e7bc50814a1
    61 N186eaa8ebfc74a738f958246bda83eef schema:name GERNGROSS TILLMAN U
    62 rdf:type schema:Person
    63 N49720670a2d445e0b1ee2cd600a0eb86 schema:name VASQUEZ MAXIMILIANO
    64 rdf:type schema:Person
    65 N6b873a67fee6432b91ce1b21e285a867 schema:name Springer Nature - SN SciGraph project
    66 rdf:type schema:Organization
    67 N6ef25e9b7ad14b26ad22661a865d8063 schema:name FELDHAUS MICHAEL
    68 rdf:type schema:Person
    69 N9a4a533731834883a8c140c24ca3dfdb rdf:first N186eaa8ebfc74a738f958246bda83eef
    70 rdf:rest N0a4e7cf1487744baa13c56e2d34b6353
    71 Ndcc7fa89a5d5443293216eea76e7491e schema:name WITTRUP K DANE
    72 rdf:type schema:Person
    73 Ne8334220759d45ac93d39e7bc50814a1 rdf:first N6ef25e9b7ad14b26ad22661a865d8063
    74 rdf:rest N9a4a533731834883a8c140c24ca3dfdb
    75 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    76 rdf:type schema:DefinedTerm
    77 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    78 rdf:type schema:DefinedTerm
    79 sg:pub.10.1007/bf00345502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016618982
    80 https://doi.org/10.1007/bf00345502
    81 rdf:type schema:CreativeWork
    82 sg:pub.10.1007/s00251-002-0468-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010656782
    83 https://doi.org/10.1007/s00251-002-0468-2
    84 rdf:type schema:CreativeWork
    85 sg:pub.10.1007/s00251-005-0062-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019809538
    86 https://doi.org/10.1007/s00251-005-0062-5
    87 rdf:type schema:CreativeWork
    88 sg:pub.10.1007/s00251-007-0270-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001224932
    89 https://doi.org/10.1007/s00251-007-0270-2
    90 rdf:type schema:CreativeWork
    91 sg:pub.10.1007/s00251-008-0325-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1009496018
    92 https://doi.org/10.1007/s00251-008-0325-z
    93 rdf:type schema:CreativeWork
    94 sg:pub.10.1007/s002530100802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003402614
    95 https://doi.org/10.1007/s002530100802
    96 rdf:type schema:CreativeWork
    97 sg:pub.10.1007/s002539900307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037271551
    98 https://doi.org/10.1007/s002539900307
    99 rdf:type schema:CreativeWork
    100 sg:pub.10.1007/s11095-011-0405-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012968826
    101 https://doi.org/10.1007/s11095-011-0405-x
    102 rdf:type schema:CreativeWork
    103 sg:pub.10.1007/s12033-010-9312-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015128428
    104 https://doi.org/10.1007/s12033-010-9312-3
    105 rdf:type schema:CreativeWork
    106 sg:pub.10.1038/256495a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001387921
    107 https://doi.org/10.1038/256495a0
    108 rdf:type schema:CreativeWork
    109 sg:pub.10.1038/290565a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020825524
    110 https://doi.org/10.1038/290565a0
    111 rdf:type schema:CreativeWork
    112 sg:pub.10.1038/314446a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003708008
    113 https://doi.org/10.1038/314446a0
    114 rdf:type schema:CreativeWork
    115 sg:pub.10.1038/321522a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007617918
    116 https://doi.org/10.1038/321522a0
    117 rdf:type schema:CreativeWork
    118 sg:pub.10.1038/332323a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016704652
    119 https://doi.org/10.1038/332323a0
    120 rdf:type schema:CreativeWork
    121 sg:pub.10.1038/340245a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028860985
    122 https://doi.org/10.1038/340245a0
    123 rdf:type schema:CreativeWork
    124 sg:pub.10.1038/341544a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030400388
    125 https://doi.org/10.1038/341544a0
    126 rdf:type schema:CreativeWork
    127 sg:pub.10.1038/342877a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003340695
    128 https://doi.org/10.1038/342877a0
    129 rdf:type schema:CreativeWork
    130 sg:pub.10.1038/348552a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009781465
    131 https://doi.org/10.1038/348552a0
    132 rdf:type schema:CreativeWork
    133 sg:pub.10.1038/349293a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027225150
    134 https://doi.org/10.1038/349293a0
    135 rdf:type schema:CreativeWork
    136 sg:pub.10.1038/35001009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035773549
    137 https://doi.org/10.1038/35001009
    138 rdf:type schema:CreativeWork
    139 sg:pub.10.1038/351501a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025716632
    140 https://doi.org/10.1038/351501a0
    141 rdf:type schema:CreativeWork
    142 sg:pub.10.1038/352624a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021945431
    143 https://doi.org/10.1038/352624a0
    144 rdf:type schema:CreativeWork
    145 sg:pub.10.1038/366469a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000948603
    146 https://doi.org/10.1038/366469a0
    147 rdf:type schema:CreativeWork
    148 sg:pub.10.1038/380364a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004838712
    149 https://doi.org/10.1038/380364a0
    150 rdf:type schema:CreativeWork
    151 sg:pub.10.1038/71958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007437849
    152 https://doi.org/10.1038/71958
    153 rdf:type schema:CreativeWork
    154 sg:pub.10.1038/77325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041511297
    155 https://doi.org/10.1038/77325
    156 rdf:type schema:CreativeWork
    157 sg:pub.10.1038/82407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011912944
    158 https://doi.org/10.1038/82407
    159 rdf:type schema:CreativeWork
    160 sg:pub.10.1038/nbt.2076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003971085
    161 https://doi.org/10.1038/nbt.2076
    162 rdf:type schema:CreativeWork
    163 sg:pub.10.1038/nbt0197-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052564290
    164 https://doi.org/10.1038/nbt0197-29
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1038/nbt0691-545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014209564
    167 https://doi.org/10.1038/nbt0691-545
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1038/nbt0697-553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017819354
    170 https://doi.org/10.1038/nbt0697-553
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/nbt0792-779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007019873
    173 https://doi.org/10.1038/nbt0792-779
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/nbt0898-778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037590787
    176 https://doi.org/10.1038/nbt0898-778
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/nbt1067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005964635
    179 https://doi.org/10.1038/nbt1067
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1038/nbt1127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045032676
    182 https://doi.org/10.1038/nbt1127
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1038/nbt1137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035568197
    185 https://doi.org/10.1038/nbt1137
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/nbt1142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018849649
    188 https://doi.org/10.1038/nbt1142
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/nbt1166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045244248
    191 https://doi.org/10.1038/nbt1166
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nbt1210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005554229
    194 https://doi.org/10.1038/nbt1210
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nbt1296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015036233
    197 https://doi.org/10.1038/nbt1296
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/ng0797-277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007071524
    200 https://doi.org/10.1038/ng0797-277
    201 rdf:type schema:CreativeWork
    202 grid-institutes:grid.508569.7 schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...