Apparatus for patterning hydrogels into multi-well plates


Ontology type: sgo:Patent     


Patent Info

DATE

2018-09-11T00:00

AUTHORS

Kolin C. HRIBAR , Padraig Buckley

ABSTRACT

The inventive subject matter provides an apparatus for reproducibly fabricating hydrogel-based organ and tumor models inside multi-well plates. For example, tumor models made using the inventive apparatus can be used for studying the progression of cancer, cancer diagnostics, and therapeutic screening. A mold controls the thickness of each hydrogel layer. A photomask controls the size and shape of each hydrogel layer, allowing the hydrogel diameter to be smaller than the diameter of each well so that liquid media can be exchanged around both the sides and top of the hydrogels. A holder aligns the photomask with the multi-well plate, and polymerization is initiated by a light source. More... »

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