Screening for structural variants


Ontology type: sgo:Patent     


Patent Info

DATE

2018-09-04T00:00

AUTHORS

Athurva Gore , Mark Umbarger

ABSTRACT

The invention relates to carrier screening and methods for describing a structural variant, such as a large rearrangement or chromosomal abnormality, in a person's genome using probes that are designed to determine the person's genetic sequence and reveal substitution mutations and small structural variants. Identifying a structural variant may include exposing a nucleic acid to a plurality of probes. Each probe has a linked pair of targeting arms designed to hybridize upstream and downstream of a target in a genome. The method includes hybridizing two of the probes to the nucleic acid and attaching the two probes together to create an inter-probe product as well as detecting the inter-probe product and reporting a structural variant of the genome in the nucleic acid. More... »

Related SciGraph Publications

  • 2010-02. Target-enrichment strategies for next-generation sequencing in NATURE METHODS
  • 2011-07. An integrated semiconductor device enabling non-optical genome sequencing in NATURE
  • 2009-09-10. Targeted capture and massively parallel sequencing of 12 human exomes in NATURE
  • 2013-07-28. Rapid and accurate large-scale genotyping of duplicated genes and discovery of interlocus gene conversions in NATURE METHODS
  • 2011-02-03. Mapping copy number variation by population-scale genome sequencing in NATURE
  • 2012-02. De novo assembly and genotyping of variants using colored de Bruijn graphs in NATURE GENETICS
  • 2009-02. Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing in NATURE BIOTECHNOLOGY
  • 2005-09. Genome sequencing in microfabricated high-density picolitre reactors in NATURE
  • 2007-11. Multiplex amplification of large sets of human exons in NATURE METHODS
  • 2009-01. Targeted next-generation sequencing by specific capture of multiple genomic loci using low-volume microfluidic DNA arrays in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2008-02. Parallel tagged sequencing on the 454 platform in NATURE PROTOCOLS
  • 2003-06. Multiplexed genotyping with sequence-tagged molecular inversion probes in NATURE BIOTECHNOLOGY
  • 2014-06. Resolving genomic disorder–associated breakpoints within segmental DNA duplications using massively parallel sequencing in NATURE PROTOCOLS
  • 2009-05. Massively parallel exon capture and library-free resequencing across 16 genomes in NATURE METHODS
  • 2009-04. Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming in NATURE BIOTECHNOLOGY
  • 2009-04. Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells in NATURE BIOTECHNOLOGY
  • 2004-09. Dosage analysis of cancer predisposition genes by multiplex ligation-dependent probe amplification in BRITISH JOURNAL OF CANCER
  • 2010-05. A novel custom resequencing array for dilated cardiomyopathy in GENETICS IN MEDICINE
  • 2004-10. Finishing the euchromatic sequence of the human genome in NATURE
  • 2004-10. Cystic fibrosis population carrier screening: 2004 revision of American College of Medical Genetics mutation panel in GENETICS IN MEDICINE
  • 2012-09. BIND – An algorithm for loss-less compression of nucleotide sequence data in JOURNAL OF BIOSCIENCES
  • 2007-12. Genome-wide in situ exon capture for selective resequencing in NATURE GENETICS
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2620", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "Athurva Gore", 
            "type": "Person"
          }, 
          {
            "name": "Mark Umbarger", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1136/gutjnl-2011-300645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001702029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcf.2008.03.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001763694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.33.12.1022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001789439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-3800(96)01925-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002667883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btt047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002972495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(01)02320-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003778369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1166/jnn.2011.3056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003901743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2004.tb02195.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003977434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2004.tb02195.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003977434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/3.11.2985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004127559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004413749", 
              "https://doi.org/10.1038/nbt.1533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0896(98)00098-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004607716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/24.20.3879", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004732894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0007767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004891182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/21.14.3191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005654904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3495(98)77870-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006419564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abio.1996.0360", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006677388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1164368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006710792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1469-1809.2003.00028.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006841894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btg034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007242262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007480955", 
              "https://doi.org/10.1038/nature10242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmoldx.2013.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007497687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmoldx.2013.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007497687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btm404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007683223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1525-1578(10)60523-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007884765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008270984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cancergencyto.2009.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008484859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cancergencyto.2009.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008484859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008728252", 
              "https://doi.org/10.1038/nbt821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008728252", 
              "https://doi.org/10.1038/nbt821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq742", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009037552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/01.gim.0000139506.11694.7c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010381968", 
              "https://doi.org/10.1097/01.gim.0000139506.11694.7c"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/01.gim.0000139506.11694.7c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010381968", 
              "https://doi.org/10.1097/01.gim.0000139506.11694.7c"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/01.gim.0000139506.11694.7c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010381968", 
              "https://doi.org/10.1097/01.gim.0000139506.11694.7c"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bies.200900181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010604039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bies.200900181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010604039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-008-2460-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011118938", 
              "https://doi.org/10.1007/s00216-008-2460-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00216-008-2460-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011118938", 
              "https://doi.org/10.1007/s00216-008-2460-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.2009.067215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011214318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.089532.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011404279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011927149", 
              "https://doi.org/10.1038/nmeth.2572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btn025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012266713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2007.42", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012402265", 
              "https://doi.org/10.1038/ng.2007.42"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2007.520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012965453", 
              "https://doi.org/10.1038/nprot.2007.520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0000915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013523183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013534924", 
              "https://doi.org/10.1038/nature03001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013534924", 
              "https://doi.org/10.1038/nature03001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.1.1.5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014070222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1000589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014840377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.f.248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014925042", 
              "https://doi.org/10.1038/nmeth.f.248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.f.248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014925042", 
              "https://doi.org/10.1038/nmeth.f.248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3495(69)86452-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015011848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btl629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017299791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-genom-082908-150112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017422233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/16.6.548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017609583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3346/jkms.2010.25.1.163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017733566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.1028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017955952", 
              "https://doi.org/10.1038/ng.1028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btt771", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020504481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0026511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021403755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021574562", 
              "https://doi.org/10.1038/nature03959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021574562", 
              "https://doi.org/10.1038/nature03959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/21.15.3347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025090585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.74.12.5463", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025360556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0023455", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025564885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0059190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025781204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ygeno.2009.06.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025792782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1373/clinchem.2006.067603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025834725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026681560", 
              "https://doi.org/10.1038/sj.bjc.6602121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026681560", 
              "https://doi.org/10.1038/sj.bjc.6602121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/jmoldx.2009.080106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027566800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-genet-072610-155046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028183527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/rcm.1290091007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029048598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/rcm.1290091007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029048598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bib/bbs017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029766327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.3185605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029969824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1150427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030422156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1167/iovs.09-4085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030471528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.bi.50.070181.001441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030905716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibtech.2005.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031289666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibtech.2005.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031289666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.33.7.550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031431088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031583743", 
              "https://doi.org/10.1038/nbt.1530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btn032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032165726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032266264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mc.2940040104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032602414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/22.19.3866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032666259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.147686.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033444277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034732435", 
              "https://doi.org/10.1038/nature09708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.mi.25.100171.001101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035198653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abio.1998.2812", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035799392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkp1137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037112607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abio.2001.5493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038531733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038593056", 
              "https://doi.org/10.1038/nature08250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038593056", 
              "https://doi.org/10.1038/nature08250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.22.8923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039123289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abio.1996.0243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040371152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040653661", 
              "https://doi.org/10.1038/nbt.1523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12038-012-9230-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040802161", 
              "https://doi.org/10.1007/s12038-012-9230-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.12.6803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042140158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042265948", 
              "https://doi.org/10.1038/nmeth.1419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042265948", 
              "https://doi.org/10.1038/nmeth.1419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/amiajnl-2013-002147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042410880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/22.22.4673", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042438223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ygeno.2004.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042854579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.101360.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043173329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1525-1578(10)60557-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043177664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gni070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043825959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/6.11.3543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044432089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2014.096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044452566", 
              "https://doi.org/10.1038/nprot.2014.096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/13.3.235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044605581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gni177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044827446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pd.1943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045566537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth1110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045927978", 
              "https://doi.org/10.1038/nmeth1110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1107739108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046112589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abio.1998.2569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046239614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/gim.0b013e3181d6f7c0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046839357", 
              "https://doi.org/10.1097/gim.0b013e3181d6f7c0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/gim.0b013e3181d6f7c0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046839357", 
              "https://doi.org/10.1097/gim.0b013e3181d6f7c0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0803240105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051295955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0731-7085(95)01534-r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052651434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac951213n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055072528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac951213n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055072528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac961186g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055073216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac961186g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055073216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00591a005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055181913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja017746x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055818917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja017746x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055818917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jp062287d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056066208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jp062287d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056066208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1194573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062462703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2983426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062579164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.14.1925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071360211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2144/02323rv01", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075019606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.8.8.848", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083311871"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-09-04T00:00", 
        "description": "

    The invention relates to carrier screening and methods for describing a structural variant, such as a large rearrangement or chromosomal abnormality, in a person's genome using probes that are designed to determine the person's genetic sequence and reveal substitution mutations and small structural variants. Identifying a structural variant may include exposing a nucleic acid to a plurality of probes. Each probe has a linked pair of targeting arms designed to hybridize upstream and downstream of a target in a genome. The method includes hybridizing two of the probes to the nucleic acid and attaching the two probes together to create an inter-probe product as well as detecting the inter-probe product and reporting a structural variant of the genome in the nucleic acid.

    ", "id": "sg:patent.US-10066259-B2", "keywords": [ "Mass Screening", "structural variant", "invention", "carrier screening", "method", "rearrangement", "Chromosome Aberration", "genome", "probe", "genetic sequence", "substitution", "nucleic acid", "plurality", "pair", "arm", "target", "product" ], "name": "Screening for structural variants", "sameAs": [ "https://app.dimensions.ai/details/patent/US-10066259-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:23", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_01822.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-10066259-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-10066259-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-10066259-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-10066259-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    399 TRIPLES      14 PREDICATES      142 URIs      25 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-10066259-B2 schema:about anzsrc-for:2620
    2 schema:author Ned6ebf2e23ba4568af184eaef5a44a1b
    3 schema:citation sg:pub.10.1007/s00216-008-2460-7
    4 sg:pub.10.1007/s12038-012-9230-6
    5 sg:pub.10.1038/nature03001
    6 sg:pub.10.1038/nature03959
    7 sg:pub.10.1038/nature08250
    8 sg:pub.10.1038/nature09708
    9 sg:pub.10.1038/nature10242
    10 sg:pub.10.1038/nbt.1523
    11 sg:pub.10.1038/nbt.1530
    12 sg:pub.10.1038/nbt.1533
    13 sg:pub.10.1038/nbt821
    14 sg:pub.10.1038/ng.1028
    15 sg:pub.10.1038/ng.2007.42
    16 sg:pub.10.1038/nmeth.1419
    17 sg:pub.10.1038/nmeth.2572
    18 sg:pub.10.1038/nmeth.f.248
    19 sg:pub.10.1038/nmeth1110
    20 sg:pub.10.1038/nprot.2007.520
    21 sg:pub.10.1038/nprot.2014.096
    22 sg:pub.10.1038/sj.bjc.6602121
    23 sg:pub.10.1097/01.gim.0000139506.11694.7c
    24 sg:pub.10.1097/gim.0b013e3181d6f7c0
    25 https://doi.org/10.1002/bies.200900181
    26 https://doi.org/10.1002/mc.2940040104
    27 https://doi.org/10.1002/pd.1943
    28 https://doi.org/10.1002/rcm.1290091007
    29 https://doi.org/10.1006/abio.1996.0243
    30 https://doi.org/10.1006/abio.1996.0360
    31 https://doi.org/10.1006/abio.1998.2569
    32 https://doi.org/10.1006/abio.1998.2812
    33 https://doi.org/10.1006/abio.2001.5493
    34 https://doi.org/10.1016/0731-7085(95)01534-r
    35 https://doi.org/10.1016/j.cancergencyto.2009.03.005
    36 https://doi.org/10.1016/j.jcf.2008.03.009
    37 https://doi.org/10.1016/j.jmoldx.2013.10.006
    38 https://doi.org/10.1016/j.tibtech.2005.12.005
    39 https://doi.org/10.1016/j.ygeno.2004.10.005
    40 https://doi.org/10.1016/j.ygeno.2009.06.006
    41 https://doi.org/10.1016/s0006-3495(69)86452-0
    42 https://doi.org/10.1016/s0006-3495(98)77870-1
    43 https://doi.org/10.1016/s0168-9525(01)02320-4
    44 https://doi.org/10.1016/s0304-3800(96)01925-4
    45 https://doi.org/10.1016/s0968-0896(98)00098-4
    46 https://doi.org/10.1016/s1525-1578(10)60523-5
    47 https://doi.org/10.1016/s1525-1578(10)60557-0
    48 https://doi.org/10.1021/ac951213n
    49 https://doi.org/10.1021/ac961186g
    50 https://doi.org/10.1021/bi00591a005
    51 https://doi.org/10.1021/ja017746x
    52 https://doi.org/10.1021/jp062287d
    53 https://doi.org/10.1046/j.1469-1809.2003.00028.x
    54 https://doi.org/10.1073/pnas.0803240105
    55 https://doi.org/10.1073/pnas.1107739108
    56 https://doi.org/10.1073/pnas.74.12.5463
    57 https://doi.org/10.1073/pnas.87.22.8923
    58 https://doi.org/10.1073/pnas.95.12.6803
    59 https://doi.org/10.1093/bib/bbs017
    60 https://doi.org/10.1093/bioinformatics/13.3.235
    61 https://doi.org/10.1093/bioinformatics/16.6.548
    62 https://doi.org/10.1093/bioinformatics/btg034
    63 https://doi.org/10.1093/bioinformatics/btl629
    64 https://doi.org/10.1093/bioinformatics/btm404
    65 https://doi.org/10.1093/bioinformatics/btn025
    66 https://doi.org/10.1093/bioinformatics/btn032
    67 https://doi.org/10.1093/bioinformatics/btp373
    68 https://doi.org/10.1093/bioinformatics/btp394
    69 https://doi.org/10.1093/bioinformatics/btt047
    70 https://doi.org/10.1093/bioinformatics/btt771
    71 https://doi.org/10.1093/nar/21.14.3191
    72 https://doi.org/10.1093/nar/21.15.3347
    73 https://doi.org/10.1093/nar/22.19.3866
    74 https://doi.org/10.1093/nar/22.22.4673
    75 https://doi.org/10.1093/nar/24.20.3879
    76 https://doi.org/10.1093/nar/3.11.2985
    77 https://doi.org/10.1093/nar/6.11.3543
    78 https://doi.org/10.1093/nar/gkp1137
    79 https://doi.org/10.1093/nar/gkq742
    80 https://doi.org/10.1093/nar/gni070
    81 https://doi.org/10.1093/nar/gni177
    82 https://doi.org/10.1101/gr.089532.108
    83 https://doi.org/10.1101/gr.1.1.5
    84 https://doi.org/10.1101/gr.101360.109
    85 https://doi.org/10.1101/gr.147686.112
    86 https://doi.org/10.1101/gr.3185605
    87 https://doi.org/10.1101/gr.8.8.848
    88 https://doi.org/10.1111/j.1349-7006.2004.tb02195.x
    89 https://doi.org/10.1126/science.1150427
    90 https://doi.org/10.1126/science.1164368
    91 https://doi.org/10.1126/science.1194573
    92 https://doi.org/10.1126/science.2983426
    93 https://doi.org/10.1136/amiajnl-2013-002147
    94 https://doi.org/10.1136/gutjnl-2011-300645
    95 https://doi.org/10.1136/jmg.2009.067215
    96 https://doi.org/10.1136/jmg.33.12.1022
    97 https://doi.org/10.1136/jmg.33.7.550
    98 https://doi.org/10.1146/annurev-genet-072610-155046
    99 https://doi.org/10.1146/annurev-genom-082908-150112
    100 https://doi.org/10.1146/annurev.bi.50.070181.001441
    101 https://doi.org/10.1146/annurev.mi.25.100171.001101
    102 https://doi.org/10.1166/jnn.2011.3056
    103 https://doi.org/10.1167/iovs.09-4085
    104 https://doi.org/10.1371/journal.pcbi.1000589
    105 https://doi.org/10.1371/journal.pone.0000915
    106 https://doi.org/10.1371/journal.pone.0007767
    107 https://doi.org/10.1371/journal.pone.0023455
    108 https://doi.org/10.1371/journal.pone.0026511
    109 https://doi.org/10.1371/journal.pone.0059190
    110 https://doi.org/10.1373/clinchem.2006.067603
    111 https://doi.org/10.2144/02323rv01
    112 https://doi.org/10.2353/jmoldx.2009.080106
    113 https://doi.org/10.3346/jkms.2010.25.1.163
    114 https://doi.org/10.3748/wjg.14.1925
    115 schema:datePublished 2018-09-04T00:00
    116 schema:description <p id="p-0001" num="0000">The invention relates to carrier screening and methods for describing a structural variant, such as a large rearrangement or chromosomal abnormality, in a person's genome using probes that are designed to determine the person's genetic sequence and reveal substitution mutations and small structural variants. Identifying a structural variant may include exposing a nucleic acid to a plurality of probes. Each probe has a linked pair of targeting arms designed to hybridize upstream and downstream of a target in a genome. The method includes hybridizing two of the probes to the nucleic acid and attaching the two probes together to create an inter-probe product as well as detecting the inter-probe product and reporting a structural variant of the genome in the nucleic acid.</p>
    117 schema:keywords Chromosome Aberration
    118 Mass Screening
    119 arm
    120 carrier screening
    121 genetic sequence
    122 genome
    123 invention
    124 method
    125 nucleic acid
    126 pair
    127 plurality
    128 probe
    129 product
    130 rearrangement
    131 structural variant
    132 substitution
    133 target
    134 schema:name Screening for structural variants
    135 schema:sameAs https://app.dimensions.ai/details/patent/US-10066259-B2
    136 schema:sdDatePublished 2019-04-18T10:23
    137 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    138 schema:sdPublisher N90ae8e47cde94048b8c138907b0820b3
    139 sgo:license sg:explorer/license/
    140 sgo:sdDataset patents
    141 rdf:type sgo:Patent
    142 N23c7bc3f4fc847d596e3fb5b9aeaa893 schema:name Mark Umbarger
    143 rdf:type schema:Person
    144 N70e6109b92f141ebb314c7742baf93a4 schema:name Athurva Gore
    145 rdf:type schema:Person
    146 N90ae8e47cde94048b8c138907b0820b3 schema:name Springer Nature - SN SciGraph project
    147 rdf:type schema:Organization
    148 Nb51dc44f212c4948813c38660cd14cd8 rdf:first N23c7bc3f4fc847d596e3fb5b9aeaa893
    149 rdf:rest rdf:nil
    150 Ned6ebf2e23ba4568af184eaef5a44a1b rdf:first N70e6109b92f141ebb314c7742baf93a4
    151 rdf:rest Nb51dc44f212c4948813c38660cd14cd8
    152 anzsrc-for:2620 schema:inDefinedTermSet anzsrc-for:
    153 rdf:type schema:DefinedTerm
    154 sg:pub.10.1007/s00216-008-2460-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011118938
    155 https://doi.org/10.1007/s00216-008-2460-7
    156 rdf:type schema:CreativeWork
    157 sg:pub.10.1007/s12038-012-9230-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040802161
    158 https://doi.org/10.1007/s12038-012-9230-6
    159 rdf:type schema:CreativeWork
    160 sg:pub.10.1038/nature03001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013534924
    161 https://doi.org/10.1038/nature03001
    162 rdf:type schema:CreativeWork
    163 sg:pub.10.1038/nature03959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021574562
    164 https://doi.org/10.1038/nature03959
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1038/nature08250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038593056
    167 https://doi.org/10.1038/nature08250
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1038/nature09708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034732435
    170 https://doi.org/10.1038/nature09708
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/nature10242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007480955
    173 https://doi.org/10.1038/nature10242
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/nbt.1523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040653661
    176 https://doi.org/10.1038/nbt.1523
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/nbt.1530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031583743
    179 https://doi.org/10.1038/nbt.1530
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1038/nbt.1533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004413749
    182 https://doi.org/10.1038/nbt.1533
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1038/nbt821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008728252
    185 https://doi.org/10.1038/nbt821
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/ng.1028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017955952
    188 https://doi.org/10.1038/ng.1028
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/ng.2007.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012402265
    191 https://doi.org/10.1038/ng.2007.42
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nmeth.1419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042265948
    194 https://doi.org/10.1038/nmeth.1419
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nmeth.2572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011927149
    197 https://doi.org/10.1038/nmeth.2572
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/nmeth.f.248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014925042
    200 https://doi.org/10.1038/nmeth.f.248
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/nmeth1110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045927978
    203 https://doi.org/10.1038/nmeth1110
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/nprot.2007.520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012965453
    206 https://doi.org/10.1038/nprot.2007.520
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/nprot.2014.096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044452566
    209 https://doi.org/10.1038/nprot.2014.096
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/sj.bjc.6602121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026681560
    212 https://doi.org/10.1038/sj.bjc.6602121
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1097/01.gim.0000139506.11694.7c schema:sameAs https://app.dimensions.ai/details/publication/pub.1010381968
    215 https://doi.org/10.1097/01.gim.0000139506.11694.7c
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1097/gim.0b013e3181d6f7c0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046839357
    218 https://doi.org/10.1097/gim.0b013e3181d6f7c0
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1002/bies.200900181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010604039
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1002/mc.2940040104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032602414
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1002/pd.1943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045566537
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1002/rcm.1290091007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029048598
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1006/abio.1996.0243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040371152
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1006/abio.1996.0360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006677388
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1006/abio.1998.2569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046239614
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1006/abio.1998.2812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035799392
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1006/abio.2001.5493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038531733
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/0731-7085(95)01534-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1052651434
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/j.cancergencyto.2009.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008484859
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/j.jcf.2008.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001763694
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/j.jmoldx.2013.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007497687
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.tibtech.2005.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031289666
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.ygeno.2004.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042854579
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.ygeno.2009.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025792782
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/s0006-3495(69)86452-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015011848
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/s0006-3495(98)77870-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006419564
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/s0168-9525(01)02320-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003778369
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/s0304-3800(96)01925-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002667883
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/s0968-0896(98)00098-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004607716
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/s1525-1578(10)60523-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007884765
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/s1525-1578(10)60557-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043177664
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1021/ac951213n schema:sameAs https://app.dimensions.ai/details/publication/pub.1055072528
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1021/ac961186g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055073216
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1021/bi00591a005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055181913
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1021/ja017746x schema:sameAs https://app.dimensions.ai/details/publication/pub.1055818917
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1021/jp062287d schema:sameAs https://app.dimensions.ai/details/publication/pub.1056066208
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1046/j.1469-1809.2003.00028.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006841894
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1073/pnas.0803240105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051295955
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1073/pnas.1107739108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046112589
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1073/pnas.74.12.5463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025360556
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1073/pnas.87.22.8923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039123289
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1073/pnas.95.12.6803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042140158
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1093/bib/bbs017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029766327
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1093/bioinformatics/13.3.235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044605581
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1093/bioinformatics/16.6.548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017609583
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1093/bioinformatics/btg034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007242262
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1093/bioinformatics/btl629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017299791
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1093/bioinformatics/btm404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007683223
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1093/bioinformatics/btn025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012266713
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1093/bioinformatics/btn032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032165726
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1093/bioinformatics/btp373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008270984
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1093/bioinformatics/btp394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032266264
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1093/bioinformatics/btt047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002972495
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1093/bioinformatics/btt771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020504481
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1093/nar/21.14.3191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005654904
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1093/nar/21.15.3347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025090585
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1093/nar/22.19.3866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032666259
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1093/nar/22.22.4673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042438223
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1093/nar/24.20.3879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004732894
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1093/nar/3.11.2985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004127559
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1093/nar/6.11.3543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044432089
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1093/nar/gkp1137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037112607
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1093/nar/gkq742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009037552
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1093/nar/gni070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043825959
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1093/nar/gni177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044827446
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1101/gr.089532.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011404279
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1101/gr.1.1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014070222
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1101/gr.101360.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043173329
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1101/gr.147686.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033444277
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1101/gr.3185605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029969824
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1101/gr.8.8.848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083311871
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1111/j.1349-7006.2004.tb02195.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003977434
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1126/science.1150427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030422156
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1126/science.1164368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006710792
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1126/science.1194573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062462703
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1126/science.2983426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062579164
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1136/amiajnl-2013-002147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042410880
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1136/gutjnl-2011-300645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001702029
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1136/jmg.2009.067215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011214318
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1136/jmg.33.12.1022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001789439
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1136/jmg.33.7.550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031431088
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1146/annurev-genet-072610-155046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028183527
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1146/annurev-genom-082908-150112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017422233
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1146/annurev.bi.50.070181.001441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030905716
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1146/annurev.mi.25.100171.001101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035198653
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1166/jnn.2011.3056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003901743
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1167/iovs.09-4085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030471528
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1371/journal.pcbi.1000589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014840377
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1371/journal.pone.0000915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013523183
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1371/journal.pone.0007767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004891182
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1371/journal.pone.0023455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025564885
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1371/journal.pone.0026511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021403755
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1371/journal.pone.0059190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025781204
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1373/clinchem.2006.067603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025834725
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.2144/02323rv01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075019606
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.2353/jmoldx.2009.080106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027566800
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.3346/jkms.2010.25.1.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017733566
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.3748/wjg.14.1925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071360211
    399 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...