Methods for non-invasive prenatal ploidy calling


Ontology type: sgo:Patent     


Patent Info

DATE

2018-08-28T00:00

AUTHORS

Matthew Rabinowitz , Allison Ryan , George Gemelos , Milena Banjevic , Zachary Demko

ABSTRACT

Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus. More... »

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Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.

", "id": "sg:patent.US-10061889-B2", "keywords": [ "method", "Ploidies", "copy number", "chromosome", "fetus", "prenatal diagnosis", "embodiment", "genetic data", "sample", "gene", "fetal DNA", "DNA", "biological parent", "maternal serum", "single nucleotide polymorphism", "microarrays", "genomic data", "determination", "clinical decision" ], "name": "Methods for non-invasive prenatal ploidy calling", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.434549.b", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-10061889-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:23", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_01818.jsonl", "type": "Patent" } ]
 

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204 schema:description <p>Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.</p>
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