Method and system for extraction and normalization of relationships via ontology induction


Ontology type: sgo:Patent     


Patent Info

DATE

2018-07-17T00:00

AUTHORS

Adrien Coulet , Nigam H. Shah , Yael Garten , Mark Musen , Russ B. Altman

ABSTRACT

Methods for developing an ontology of pharmacogenomics (PGx) relationships starting from a lexicon of key pharmacogenomic entities and a syntactic parse is described. The syntactic structure of PGx statements is used to systematically extract commonly occurring relationships and to map them to a common schema. In an embodiment, extracted relationships have a 70-87.7% precision and involve not only key PGx entities such as genes, drugs, and phenotypes (e.g., VKORC1, warfarin, clotting disorder), but also critical entities that are frequently modified by these key entities (e.g., VKORC1 polymorphism, warfarin response, clotting disorder treatment). More... »

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