Use of chimeric nucleases to stimulate gene targeting


Ontology type: sgo:Patent     


Patent Info

DATE

2018-06-26T00:00

AUTHORS

David Baltimore , Matthew Porteus

ABSTRACT

Gene targeting is a technique to introduce genetic change into one or more specific locations in the genome of a cell. For example, gene targeting can introduce genetic change by modifying, repairing, attenuating or inactivating a target gene or other chromosomal DNA. In one aspect, this disclosure relates to methods and compositions for gene targeting with high efficiency in a cell. This disclosure also relates to methods of treating or preventing a genetic disease in an individual in need thereof. Further disclosed are chimeric nucleases and vectors encoding chimeric nucleases. More... »

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