Anti-HER2 glycoantibodies and uses thereof


Ontology type: sgo:Patent     


Patent Info

DATE

2018-06-26T00:00

AUTHORS

Chi-Huey Wong , Chung-Yi Wu

ABSTRACT

The present disclosure relates to a novel class of anti-HER2 monoclonal antibodies comprising a homogeneous population of anti-HER2 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-HER2 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered. More... »

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        "datePublished": "2018-06-26T00:00", 
        "description": "

    The present disclosure relates to a novel class of anti-HER2 monoclonal antibodies comprising a homogeneous population of anti-HER2 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-HER2 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.

    ", "id": "sg:patent.US-10005847-B2", "keywords": [ "HER2", "disclosure", "novel class", "monoclonal antibody", "homogeneous population", "IgG molecule", "N-glycans", "Fc", "antibody", "invention", "glycoengineering", "improved therapeutic", "receptor binding affinity" ], "name": "Anti-HER2 glycoantibodies and uses thereof", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.28665.3f", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-10005847-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:22", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_01775.jsonl", "type": "Patent" } ]
     

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