Compounds For Increasing Genome Editing Efficiency


Ontology type: sgo:Patent     


Patent Info

DATE

2018-10-17T00:00

AUTHORS

RIESENBERG STEPHAN , MARICIC TOMISLAV

ABSTRACT

Compounds, compositions and kits to increase precise genome editing efficiency in eukaryotic cells or organisms. Combinations of at least two compounds selected from: (a) HDAC inhibitor, preferably Trichostatin A, (b) NAE inhibitor, preferably MLN4924 (c) DNA-PK inhibitor, preferably NU7026 and, (d) RPA inhibitor, preferably NSC15520. Use of a catalytically inactive mutant of DNA protein kinase catalytic subunit (DNA-PKcs) K3753R, to enhance genome editing, optionally, combined with one or more of (a) to (d). More... »

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