Methods For Engineering T Cells For Immunotherapy By Using Rna-Guided Cas Nuclease System


Ontology type: sgo:Patent     


Patent Info

DATE

2018-04-18T00:00

AUTHORS

DUCHATEAU, PHILIPPE , CHOULIKA, André , POIROT, LAURENT

ABSTRACT

The present invention relates to methods of developing genetically engineered, preferably non-alloreactive T-cells for immunotherapy. This method involves the use of RNA-guided endonucleases, in particular Cas9/CRISPR system, to specifically target a selection of key genes in T-cells. The engineered T-cells are also intended to express chimeric antigen receptors (CAR) to redirect their immune activity towards malignant or infected cells. The invention opens the way to standard and affordable adoptive immunotherapy strategies using T-Cells for treating cancer and viral infections. More... »

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    64 schema:description <p id="pa01" num="0001">The present invention relates to methods of developing genetically engineered, preferably non-alloreactive T-cells for immunotherapy. This method involves the use of RNA-guided endonucleases, in particular Cas9/CRISPR system, to specifically target a selection of key genes in T-cells. The engineered T-cells are also intended to express chimeric antigen receptors (CAR) to redirect their immune activity towards malignant or infected cells. The invention opens the way to standard and affordable adoptive immunotherapy strategies using T-Cells for treating cancer and viral infections. <img id="iaf01" file="imgaf001.tif" wi="78" he="69" img-content="drawing" img-format="tif"/></p>
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