Crispr-Based Genome Modification And Regulation


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

CHEN, FUQIANG , DAVIS, GREGORY D. , KANG, Qiaohua , KNIGHT, Scott W.

ABSTRACT

The present invention provides RNA-guided endonucleases, which are engineered for expression in eukaryotic cells or embryos, and methods of using the RNA-guided endonuclease for targeted genome modification in in eukaryotic cells or embryos. Also provided are fusion proteins, wherein each fusion protein comprises a CRISPR/Cas-like protein or fragment thereof and an effector domain. The effector domain can be a cleavage domain, an epigenetic modification domain, a transcriptional activation domain, or a transcriptional repressor domain. Also provided are methods for using the fusion proteins to modify a chromosomal sequence or regulate expression of a chromosomal sequence. More... »

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