Encapsulated Sensors And Sensing Systems For Bioassays And Diagnostics And Methods For Making And Using Them


Ontology type: sgo:Patent     


Patent Info

DATE

2017-05-03T00:00

AUTHORS

ZHAO, WEIAN , Kang, Dong-ku , ZHANG, KAIXIANG , ALI, Md Monsur , ECKERT, Mark A. , LI, FENG , GRATTON, ENRICO , DIGMAN, Michelle A. , LABANIEH, Louai , LU, Mengrou

ABSTRACT

In alternative embodiments, the invention provides high throughput, multiplexed systems or methods for detecting a biological, a physiological or a pathological maker, or a single molecule or a single cell using a droplet microfluidics system integrated with use of a sensor or a sensing system, an aptamer, or a DNAzyme. In alternative embodiments, the sensor or sensing system comprises a nucleic acid based, an antibody based, an enzyme based or a chemical based sensor or sensing system. In alternative embodiments, the invention provides methods for detecting a biological, a physiological or a pathological marker, or a single molecule or a single cell using a droplet system integrated with rapid and sensitive fluorescence detection systems including, for example, a 3D Particle Detector. In alternative embodiments, the invention provides systems comprising Integrated Comprehensive Droplet Digital Detection (IC 3D). More... »

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