Human microRNAs and methods for inhibiting same


Ontology type: sgo:Patent     


Patent Info

DATE

2013-08-28T00:00

AUTHORS

TUSCHL, THOMAS , LANDGRAF, PABLO

ABSTRACT

The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a microRNA shown in SEQ ID NOs: 1-94; 281-374; 467- 481 ; 497-522; or 549, except that up to thirty percent of the bases may be wobble bases, and up to 10% of the contiguous bases may be non-complementary. The invention further relates to modified single stranded microRNA molecules, isolated single stranded anti-microRNA molecules and isolated microRNP molecules. In another embodiment, the invention relates to a method for inhibiting microRNP activity in a cell. More... »

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