Nanoparticle compositions for generation of regulatory T cells and treatment of autoimmune diseases and other chronic inflammatory conditions


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

HERKEL, JOHANNES , Carambia, Antonella , FREUND, BARBARA , HEEREN, Jörg , NIELSEN, PETER , BRUNS, OLIVER , LOHSE, ANSGAR , Lüth, Stefan , WELLER, HORST , Salmen, Sunhild

ABSTRACT

The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core. More... »

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