Mutations of the PIK3CA gene in human cancers


Ontology type: sgo:Patent     


Patent Info

DATE

2012-09-12T00:00

AUTHORS

SAMUELS, YARDENA , VELCULESCU, VICTOR , KINZLER, KENNETH , VOGELSTEIN, BERT

ABSTRACT

Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the P13K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the P13K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3142", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "SAMUELS, YARDENA", 
        "type": "Person"
      }, 
      {
        "name": "VELCULESCU, VICTOR", 
        "type": "Person"
      }, 
      {
        "name": "KINZLER, KENNETH", 
        "type": "Person"
      }, 
      {
        "name": "VOGELSTEIN, BERT", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nbt0502-497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000546028", 
          "https://doi.org/10.1038/nbt0502-497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0502-497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000546028", 
          "https://doi.org/10.1038/nbt0502-497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(00)00172-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003776164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(94)90076-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005333298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.082117599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008914829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/iai.68.4.1820-1826.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011372268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.092143499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011544791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1997.4771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011822474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-409x(97)00092-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012818652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-409x(97)00092-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012818652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362255a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013946620", 
          "https://doi.org/10.1038/362255a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1068999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020993705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/13543784.7.4.607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029418115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00248-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031675572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0502-505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032921883", 
          "https://doi.org/10.1038/nbt0502-505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0502-505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032921883", 
          "https://doi.org/10.1038/nbt0502-505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0958-1669(95)80093-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035583642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418244a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035887015", 
          "https://doi.org/10.1038/418244a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418244a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035887015", 
          "https://doi.org/10.1038/418244a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418244a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035887015", 
          "https://doi.org/10.1038/418244a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-437x(02)00290-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044004206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-437x(02)00290-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044004206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.6.2551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053255306"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-09-12T00:00", 
    "description": "

Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the P13K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the P13K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target.

", "id": "sg:patent.EP-2497836-A1", "keywords": [ "mutation", "PIK3CA", "human cancer", "Phosphatidylinositol 3-Kinases", "PI3K", "important regulator", "signaling pathway", "Neoplasm", "sequence", "gene family", "family", "colon", "organ", "majority", "P13K", "kinase domain", "mutated oncogene", "diagnostic and therapeutic target" ], "name": "Mutations of the PIK3CA gene in human cancers", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.21107.35", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/EP-2497836-A1" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:09", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_00403.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.EP-2497836-A1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.EP-2497836-A1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.EP-2497836-A1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.EP-2497836-A1'


 

This table displays all metadata directly associated to this object as RDF triples.

110 TRIPLES      15 PREDICATES      50 URIs      26 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.EP-2497836-A1 schema:about anzsrc-for:2581
2 anzsrc-for:3142
3 schema:author N3394e891aade4a169696a5584b2c75ec
4 schema:citation sg:pub.10.1038/362255a0
5 sg:pub.10.1038/418244a
6 sg:pub.10.1038/nbt0502-497
7 sg:pub.10.1038/nbt0502-505
8 https://doi.org/10.1006/geno.1997.4771
9 https://doi.org/10.1016/0958-1669(95)80093-x
10 https://doi.org/10.1016/1074-7613(94)90076-0
11 https://doi.org/10.1016/s0169-409x(97)00092-6
12 https://doi.org/10.1016/s0959-437x(02)00290-3
13 https://doi.org/10.1016/s0960-9822(00)00172-x
14 https://doi.org/10.1016/s1535-6108(03)00248-4
15 https://doi.org/10.1073/pnas.082117599
16 https://doi.org/10.1073/pnas.092143499
17 https://doi.org/10.1073/pnas.90.6.2551
18 https://doi.org/10.1126/science.1068999
19 https://doi.org/10.1128/iai.68.4.1820-1826.2000
20 https://doi.org/10.1517/13543784.7.4.607
21 schema:datePublished 2012-09-12T00:00
22 schema:description <p num="pa01">Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the P13K gene family and discovered that one family member, PIK3CA, is frequently mutated in cancers of the colon and other organs. The majority of mutations clustered near two positions within the P13K helical or kinase domains. PIK3CA represents one of the most highly mutated oncogenes yet identified in human cancers and is useful as a diagnostic and therapeutic target.</p>
23 schema:keywords Neoplasm
24 P13K
25 PI3K
26 PIK3CA
27 Phosphatidylinositol 3-Kinases
28 colon
29 diagnostic and therapeutic target
30 family
31 gene family
32 human cancer
33 important regulator
34 kinase domain
35 majority
36 mutated oncogene
37 mutation
38 organ
39 sequence
40 signaling pathway
41 schema:name Mutations of the PIK3CA gene in human cancers
42 schema:recipient https://www.grid.ac/institutes/grid.21107.35
43 schema:sameAs https://app.dimensions.ai/details/patent/EP-2497836-A1
44 schema:sdDatePublished 2019-04-18T10:09
45 schema:sdLicense https://scigraph.springernature.com/explorer/license/
46 schema:sdPublisher N41d3a695529443299cc2a603fc10790b
47 sgo:license sg:explorer/license/
48 sgo:sdDataset patents
49 rdf:type sgo:Patent
50 N3394e891aade4a169696a5584b2c75ec rdf:first N57de5164172b4460b5b7ac037945cede
51 rdf:rest N7a1a63602cb347b0b8e104ee604e40d5
52 N41d3a695529443299cc2a603fc10790b schema:name Springer Nature - SN SciGraph project
53 rdf:type schema:Organization
54 N57de5164172b4460b5b7ac037945cede schema:name SAMUELS, YARDENA
55 rdf:type schema:Person
56 N6a641bb1054842a2999b0c764514d9d5 rdf:first N7542e7645ee845b89411de4390c1fbd6
57 rdf:rest Nfd22a1c807fb4692a54a9fecbf2f4292
58 N7542e7645ee845b89411de4390c1fbd6 schema:name KINZLER, KENNETH
59 rdf:type schema:Person
60 N7a1a63602cb347b0b8e104ee604e40d5 rdf:first Nc91875c03fb742c6a2cd222b7fe49a6d
61 rdf:rest N6a641bb1054842a2999b0c764514d9d5
62 Nb9f00ca3d4b5420fb001f03991222ba6 schema:name VOGELSTEIN, BERT
63 rdf:type schema:Person
64 Nc91875c03fb742c6a2cd222b7fe49a6d schema:name VELCULESCU, VICTOR
65 rdf:type schema:Person
66 Nfd22a1c807fb4692a54a9fecbf2f4292 rdf:first Nb9f00ca3d4b5420fb001f03991222ba6
67 rdf:rest rdf:nil
68 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
69 rdf:type schema:DefinedTerm
70 anzsrc-for:3142 schema:inDefinedTermSet anzsrc-for:
71 rdf:type schema:DefinedTerm
72 sg:pub.10.1038/362255a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013946620
73 https://doi.org/10.1038/362255a0
74 rdf:type schema:CreativeWork
75 sg:pub.10.1038/418244a schema:sameAs https://app.dimensions.ai/details/publication/pub.1035887015
76 https://doi.org/10.1038/418244a
77 rdf:type schema:CreativeWork
78 sg:pub.10.1038/nbt0502-497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000546028
79 https://doi.org/10.1038/nbt0502-497
80 rdf:type schema:CreativeWork
81 sg:pub.10.1038/nbt0502-505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032921883
82 https://doi.org/10.1038/nbt0502-505
83 rdf:type schema:CreativeWork
84 https://doi.org/10.1006/geno.1997.4771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011822474
85 rdf:type schema:CreativeWork
86 https://doi.org/10.1016/0958-1669(95)80093-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035583642
87 rdf:type schema:CreativeWork
88 https://doi.org/10.1016/1074-7613(94)90076-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005333298
89 rdf:type schema:CreativeWork
90 https://doi.org/10.1016/s0169-409x(97)00092-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012818652
91 rdf:type schema:CreativeWork
92 https://doi.org/10.1016/s0959-437x(02)00290-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044004206
93 rdf:type schema:CreativeWork
94 https://doi.org/10.1016/s0960-9822(00)00172-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003776164
95 rdf:type schema:CreativeWork
96 https://doi.org/10.1016/s1535-6108(03)00248-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031675572
97 rdf:type schema:CreativeWork
98 https://doi.org/10.1073/pnas.082117599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008914829
99 rdf:type schema:CreativeWork
100 https://doi.org/10.1073/pnas.092143499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011544791
101 rdf:type schema:CreativeWork
102 https://doi.org/10.1073/pnas.90.6.2551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053255306
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1126/science.1068999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020993705
105 rdf:type schema:CreativeWork
106 https://doi.org/10.1128/iai.68.4.1820-1826.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011372268
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1517/13543784.7.4.607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029418115
109 rdf:type schema:CreativeWork
110 https://www.grid.ac/institutes/grid.21107.35 schema:Organization
 




Preview window. Press ESC to close (or click here)


...