Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells


Ontology type: sgo:Patent     


Patent Info

DATE

2016-04-06T00:00

AUTHORS

MERCHAV, SHOSHANA , MERETSKI, SHAI , ZIPORI, DOV , KADOURI, AVINOAM

ABSTRACT

A method of expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells by obtaining undifferentiated hemopoietic stem cells or progenitor cells; and either seeding the undifferentiated hemopoietic stem cells or progenitor cells into a stationary phase plug-flow bioreactor in which a three-dimensional stromal cell culture has been pre-established on a substrate in the form of a sheet, the substrate including a non-woven fibrous matrix forming a physiologically acceptable three-dimensional network of fibers, thereby expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells, or culturing the undifferentiated hemopoietic stem cells or progenitor cells in conditioned medium obtained from such a reactor. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "MERCHAV, SHOSHANA", 
        "type": "Person"
      }, 
      {
        "name": "MERETSKI, SHAI", 
        "type": "Person"
      }, 
      {
        "name": "ZIPORI, DOV", 
        "type": "Person"
      }, 
      {
        "name": "KADOURI, AVINOAM", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1992.tb42578.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005713593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0393-358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040225469", 
          "https://doi.org/10.1038/nbt0393-358"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-04-06T00:00", 
    "description": "

A method of expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells by obtaining undifferentiated hemopoietic stem cells or progenitor cells; and either seeding the undifferentiated hemopoietic stem cells or progenitor cells into a stationary phase plug-flow bioreactor in which a three-dimensional stromal cell culture has been pre-established on a substrate in the form of a sheet, the substrate including a non-woven fibrous matrix forming a physiologically acceptable three-dimensional network of fibers, thereby expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells, or culturing the undifferentiated hemopoietic stem cells or progenitor cells in conditioned medium obtained from such a reactor.

", "id": "sg:patent.EP-2311938-B1", "keywords": [ "method", "apparatus", "expansion", "hemopoietic stem cell", "stem cell", "stationary phase", "stromal cell", "substrate", "sheet", "matrix", "three-dimensional network", "fiber", "culturing", "Conditioned Culture Medium", "reactor" ], "name": "Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.459855.0", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/EP-2311938-B1" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:17", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_01218.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.EP-2311938-B1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.EP-2311938-B1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.EP-2311938-B1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.EP-2311938-B1'


 

This table displays all metadata directly associated to this object as RDF triples.

56 TRIPLES      15 PREDICATES      31 URIs      23 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.EP-2311938-B1 schema:about anzsrc-for:2581
2 schema:author Nc5328020cf7b496c93af066c186a48da
3 schema:citation sg:pub.10.1038/nbt0393-358
4 https://doi.org/10.1111/j.1749-6632.1992.tb42578.x
5 schema:datePublished 2016-04-06T00:00
6 schema:description <p>A method of expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells by obtaining undifferentiated hemopoietic stem cells or progenitor cells; and either seeding the undifferentiated hemopoietic stem cells or progenitor cells into a stationary phase plug-flow bioreactor in which a three-dimensional stromal cell culture has been pre-established on a substrate in the form of a sheet, the substrate including a non-woven fibrous matrix forming a physiologically acceptable three-dimensional network of fibers, thereby expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells, or culturing the undifferentiated hemopoietic stem cells or progenitor cells in conditioned medium obtained from such a reactor.</p>
7 schema:keywords Conditioned Culture Medium
8 apparatus
9 culturing
10 expansion
11 fiber
12 hemopoietic stem cell
13 matrix
14 method
15 reactor
16 sheet
17 stationary phase
18 stem cell
19 stromal cell
20 substrate
21 three-dimensional network
22 schema:name Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
23 schema:recipient https://www.grid.ac/institutes/grid.459855.0
24 schema:sameAs https://app.dimensions.ai/details/patent/EP-2311938-B1
25 schema:sdDatePublished 2019-04-18T10:17
26 schema:sdLicense https://scigraph.springernature.com/explorer/license/
27 schema:sdPublisher Ndc6209148a1b4740b410d20176819e9b
28 sgo:license sg:explorer/license/
29 sgo:sdDataset patents
30 rdf:type sgo:Patent
31 N0a60ff9e4d734e519b02cf258fe6321c schema:name ZIPORI, DOV
32 rdf:type schema:Person
33 N388bcb21632c4e1ca79c95ebed87ba41 rdf:first Nce7060a65583420691b28a608fc7350e
34 rdf:rest rdf:nil
35 N79979748de8e4997af0791f1b4bcf3fd rdf:first N0a60ff9e4d734e519b02cf258fe6321c
36 rdf:rest N388bcb21632c4e1ca79c95ebed87ba41
37 N8297a1c32735420fae3a2c540881b22d schema:name MERCHAV, SHOSHANA
38 rdf:type schema:Person
39 Nc3ecffcd318548ba9e9eaf64a6c7b763 schema:name MERETSKI, SHAI
40 rdf:type schema:Person
41 Nc5328020cf7b496c93af066c186a48da rdf:first N8297a1c32735420fae3a2c540881b22d
42 rdf:rest Nd0f2826be8b64dc29cb054811c9a6bd6
43 Nce7060a65583420691b28a608fc7350e schema:name KADOURI, AVINOAM
44 rdf:type schema:Person
45 Nd0f2826be8b64dc29cb054811c9a6bd6 rdf:first Nc3ecffcd318548ba9e9eaf64a6c7b763
46 rdf:rest N79979748de8e4997af0791f1b4bcf3fd
47 Ndc6209148a1b4740b410d20176819e9b schema:name Springer Nature - SN SciGraph project
48 rdf:type schema:Organization
49 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
50 rdf:type schema:DefinedTerm
51 sg:pub.10.1038/nbt0393-358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040225469
52 https://doi.org/10.1038/nbt0393-358
53 rdf:type schema:CreativeWork
54 https://doi.org/10.1111/j.1749-6632.1992.tb42578.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005713593
55 rdf:type schema:CreativeWork
56 https://www.grid.ac/institutes/grid.459855.0 schema:Organization
 




Preview window. Press ESC to close (or click here)


...