Chimeric Natriuretic Polypeptides And Methods For Inhibiting Cardiac Remodeling


Ontology type: sgo:Patent     


Patent Info

DATE

2011-04-06T00:00

AUTHORS

BURNETT JOHN C , CHEN HORNG H , LISY ONDREJ

ABSTRACT

Materials and methods related to chimeric polypeptides containing the amino acid sequence of CNP and the C-terminal sequence of DNP. The polypeptides are natriuretic and diuretic, GFR enhancing, cardiac unloading, renin inhibiting and less hypotensive when compared to BNP. The polypeptides also inhibit cardiac fibroblast proliferation.

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