Use of compositions comprising Dkk2 and fragments thereof for the stimulation or enhancement of bone formation


Ontology type: sgo:Patent     


Patent Info

DATE

2010-11-10T00:00

AUTHORS

LI, XIAOFENG , LIU, PENG , LIU, WENZHONG , ENGELHARDT, DEAN , WU, DIANQING

ABSTRACT

Compositions and methods for the treatment of bone diseases, bone fractures, bone injuries and other bone abnormalities involving the use of Dkk protein, a Wnt antagonist, a Wnt inhibitor, or any other related protein for the stimulation or enhancement of mineralization and for stimulating the renewal of cells. One Dkk protein, Dickkopf-2 (Dkk-2), acts to stimulate bone formation independently of Wnt proteins which may be inhibited and/or antagonized by Dkk-2. Dkk-2 displayed enhanced specific targeting ability and enhanced biological activity in stimulating or enhancing mineralization. Dkk-2 also played a role in the differentiation and self-renewal of hematopoietic stem cells and mesenchymal stem cells, particularly in osteoblastogenesis and osteoclastogenesis. More... »

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