METHOD OF SCREENING USING c-MET, A NOVEL SUBSTRATE FOR GAMMA-SECRETASE


Ontology type: sgo:Patent     


Patent Info

DATE

2010-04-21T00:00

AUTHORS

INOUE EIJI

ABSTRACT

The present invention relates to a method of screening for compounds which affect the processing of c-Met by γ-secretase, comprising the following steps: (i) contacting a first biological composition containing γ-secretase or a biologically active fragment thereof with a second biological composition containing c-Met in the presence and absence of a candidate compound; (ii) measuring the cleavage of the c-Met in the presence and absence of the candidate compound; (iii) selecting those candidate compounds which affect the cleavage of the c-Met by γ-secretase; and (iv) identifying the candidate compounds selected in step (iii) as compounds which affect the processing of c-Met by γ-secretase. More... »

Related SciGraph Publications

  • 2004-06. γ-Secretase: proteasome of the membrane? in NATURE REVIEWS MOLECULAR CELL BIOLOGY
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