N5-substituted benzo¬2,3|azepino¬4,5-b|indol-6-ones for treating tropical diseases


Ontology type: sgo:Patent     


Patent Info

DATE

2007-02-28T00:00

AUTHORS

STUHLMANN, FRIEDRICH, DR. , Jäger, Timo, Dr. , Flohé, Leopold, Prof. Dr. , SCHINZER, DIETER, PROF. DR.

ABSTRACT

The present invention relates to novel N5-substituted-benzo[2,3]azepino[4,5-b]indol-6-ones of the general formula (1): and pharmaceutically acceptable salts thereof, the use of these compounds as pharmaceutically active agents, especially for the prophylaxis and/or treatment of South American trypanosomiasis, African trypanosomiasis, sleeping sickness, Kala-Azar, visceral leishmaniasis, Baghdad boil or Aleppo boil, cutaneous leishmaniasis (CL), espundia, Chagas disease, mucocutaneous leishmaniasis (MCL), trichomoniasis, urogenital trichomonosis, giardiasis, lamblia dysentery, amoebiasis, primary amebic meningoencephalitis (PAM), keratitis or meningitis, coccidiosis, sarcosporidosis, toxoplasmosis, Malaria tropica, Malaria tertiana, Malaria quartana, pneumocystis carinii, pneumonia, pneumocystosis, Balantidium dysentery, and oriental sore. Furthermore, the present invention is directed towards pharmaceutical compositions containing at least one of the N5-substituted-benzo[2,3]azepino[4,5-b]indol-6-ones and/or pharmaceutically acceptable salts thereof. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "STUHLMANN, FRIEDRICH, DR.", 
        "type": "Person"
      }, 
      {
        "name": "J\u00e4ger, Timo, Dr.", 
        "type": "Person"
      }, 
      {
        "name": "Floh\u00e9, Leopold, Prof. Dr.", 
        "type": "Person"
      }, 
      {
        "name": "SCHINZER, DIETER, PROF. DR.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.95.9.5311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012111456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s008940100017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016197213", 
          "https://doi.org/10.1007/s008940100017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m204403200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026124924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molbiopara.2004.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027616561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2004.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039064341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-6851(85)90037-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042047396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-6851(85)90037-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042047396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m401240200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042824025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m303035200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045166405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2004.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046197242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m404486200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048894777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m010352200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049001962"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-02-28T00:00", 
    "description": "

The present invention relates to novel N5-substituted-benzo[2,3]azepino[4,5-b]indol-6-ones of the general formula (1):\n\nand pharmaceutically acceptable salts thereof, the use of these compounds as pharmaceutically active agents, especially for the prophylaxis and/or treatment of South American trypanosomiasis, African trypanosomiasis, sleeping sickness, Kala-Azar, visceral leishmaniasis, Baghdad boil or Aleppo boil, cutaneous leishmaniasis (CL), espundia, Chagas disease, mucocutaneous leishmaniasis (MCL), trichomoniasis, urogenital trichomonosis, giardiasis, lamblia dysentery, amoebiasis, primary amebic meningoencephalitis (PAM), keratitis or meningitis, coccidiosis, sarcosporidosis, toxoplasmosis, Malaria tropica, Malaria tertiana, Malaria quartana, pneumocystis carinii, pneumonia, pneumocystosis, Balantidium dysentery, and oriental sore. Furthermore, the present invention is directed towards pharmaceutical compositions containing at least one of the N5-substituted-benzo[2,3]azepino[4,5-b]indol-6-ones and/or pharmaceutically acceptable salts thereof.

", "id": "sg:patent.EP-1757607-A1", "keywords": [ "tropical disease", "invention", "benzo", "general formula", "salt", "compound", "active agent", "prophylaxis", "South American", "trypanosomiasis", "African Trypanosomiasis", "sleeping sickness", "visceral leishmaniasis", "Baghdad", "boil", "cutaneous leishmaniasis", "chaga disease", "leishmaniasis", "trichomoniasis", "trichomonosis", "giardiasis", "dysentery", "amebiasis", "meningoencephalitis", "keratitis", "meningitis", "coccidiosis", "toxoplasmosis", "malaria", "Pneumocystis carinii", "pneumonia", "Pneumocystis Pneumonia", "pharmaceutical" ], "name": "N5-substituted benzo\u00ac2,3|azepino\u00ac4,5-b|indol-6-ones for treating tropical diseases", "sameAs": [ "https://app.dimensions.ai/details/patent/EP-1757607-A1" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:25", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_02367.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.EP-1757607-A1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.EP-1757607-A1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.EP-1757607-A1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.EP-1757607-A1'


 

This table displays all metadata directly associated to this object as RDF triples.

99 TRIPLES      14 PREDICATES      57 URIs      41 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.EP-1757607-A1 schema:about anzsrc-for:3114
2 schema:author N3edf0e4e789c4cf890b1827eb489b45d
3 schema:citation sg:pub.10.1007/s008940100017
4 https://doi.org/10.1016/0166-6851(85)90037-4
5 https://doi.org/10.1016/j.freeradbiomed.2004.02.008
6 https://doi.org/10.1016/j.jsb.2004.12.005
7 https://doi.org/10.1016/j.molbiopara.2004.02.015
8 https://doi.org/10.1073/pnas.95.9.5311
9 https://doi.org/10.1074/jbc.m010352200
10 https://doi.org/10.1074/jbc.m204403200
11 https://doi.org/10.1074/jbc.m303035200
12 https://doi.org/10.1074/jbc.m401240200
13 https://doi.org/10.1074/jbc.m404486200
14 schema:datePublished 2007-02-28T00:00
15 schema:description <p num="pa01">The present invention relates to novel N<sup>5</sup>-substituted-benzo[2,3]azepino[4,5-b]indol-6-ones of the general formula (1): <chemistry id="chema01" num="0001"><img id="ia01" file="imga0001.tif" wi="121" he="66" img-content="chem" img-format="tif"/></chemistry> and pharmaceutically acceptable salts thereof, the use of these compounds as pharmaceutically active agents, especially for the prophylaxis and/or treatment of South American trypanosomiasis, African trypanosomiasis, sleeping sickness, Kala-Azar, visceral leishmaniasis, Baghdad boil or Aleppo boil, cutaneous leishmaniasis (CL), espundia, Chagas disease, mucocutaneous leishmaniasis (MCL), trichomoniasis, urogenital trichomonosis, giardiasis, lamblia dysentery, amoebiasis, primary amebic meningoencephalitis (PAM), keratitis or meningitis, coccidiosis, sarcosporidosis, toxoplasmosis, Malaria tropica, Malaria tertiana, Malaria quartana, pneumocystis carinii, pneumonia, pneumocystosis, Balantidium dysentery, and oriental sore. Furthermore, the present invention is directed towards pharmaceutical compositions containing at least one of the N<sup>5</sup>-substituted-benzo[2,3]azepino[4,5-b]indol-6-ones and/or pharmaceutically acceptable salts thereof.</p>
16 schema:keywords African Trypanosomiasis
17 Baghdad
18 Pneumocystis Pneumonia
19 Pneumocystis carinii
20 South American
21 active agent
22 amebiasis
23 benzo
24 boil
25 chaga disease
26 coccidiosis
27 compound
28 cutaneous leishmaniasis
29 dysentery
30 general formula
31 giardiasis
32 invention
33 keratitis
34 leishmaniasis
35 malaria
36 meningitis
37 meningoencephalitis
38 pharmaceutical
39 pneumonia
40 prophylaxis
41 salt
42 sleeping sickness
43 toxoplasmosis
44 trichomoniasis
45 trichomonosis
46 tropical disease
47 trypanosomiasis
48 visceral leishmaniasis
49 schema:name N5-substituted benzo¬2,3|azepino¬4,5-b|indol-6-ones for treating tropical diseases
50 schema:sameAs https://app.dimensions.ai/details/patent/EP-1757607-A1
51 schema:sdDatePublished 2019-04-18T10:25
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher N52e9737c47204a9d844072163dd25a24
54 sgo:license sg:explorer/license/
55 sgo:sdDataset patents
56 rdf:type sgo:Patent
57 N00784ce375e1482cb76b328a300c1ad2 schema:name STUHLMANN, FRIEDRICH, DR.
58 rdf:type schema:Person
59 N0b83f45c1c934112a2d3733af0dcff0f schema:name Jäger, Timo, Dr.
60 rdf:type schema:Person
61 N23582808a1b240b2991dfb1b6ac51089 schema:name SCHINZER, DIETER, PROF. DR.
62 rdf:type schema:Person
63 N2c4eb9044d2f43d88b7625737874b707 rdf:first N0b83f45c1c934112a2d3733af0dcff0f
64 rdf:rest Ncf5e1d3847784e10ad059b18db214c5b
65 N3edf0e4e789c4cf890b1827eb489b45d rdf:first N00784ce375e1482cb76b328a300c1ad2
66 rdf:rest N2c4eb9044d2f43d88b7625737874b707
67 N52e9737c47204a9d844072163dd25a24 schema:name Springer Nature - SN SciGraph project
68 rdf:type schema:Organization
69 Nc07977d22b844a0695ec655aa38fa232 schema:name Flohé, Leopold, Prof. Dr.
70 rdf:type schema:Person
71 Ncf5e1d3847784e10ad059b18db214c5b rdf:first Nc07977d22b844a0695ec655aa38fa232
72 rdf:rest Nf72c528c5ca74c7ebec7eaff6b987a58
73 Nf72c528c5ca74c7ebec7eaff6b987a58 rdf:first N23582808a1b240b2991dfb1b6ac51089
74 rdf:rest rdf:nil
75 anzsrc-for:3114 schema:inDefinedTermSet anzsrc-for:
76 rdf:type schema:DefinedTerm
77 sg:pub.10.1007/s008940100017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016197213
78 https://doi.org/10.1007/s008940100017
79 rdf:type schema:CreativeWork
80 https://doi.org/10.1016/0166-6851(85)90037-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042047396
81 rdf:type schema:CreativeWork
82 https://doi.org/10.1016/j.freeradbiomed.2004.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039064341
83 rdf:type schema:CreativeWork
84 https://doi.org/10.1016/j.jsb.2004.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046197242
85 rdf:type schema:CreativeWork
86 https://doi.org/10.1016/j.molbiopara.2004.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027616561
87 rdf:type schema:CreativeWork
88 https://doi.org/10.1073/pnas.95.9.5311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012111456
89 rdf:type schema:CreativeWork
90 https://doi.org/10.1074/jbc.m010352200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049001962
91 rdf:type schema:CreativeWork
92 https://doi.org/10.1074/jbc.m204403200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026124924
93 rdf:type schema:CreativeWork
94 https://doi.org/10.1074/jbc.m303035200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045166405
95 rdf:type schema:CreativeWork
96 https://doi.org/10.1074/jbc.m401240200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042824025
97 rdf:type schema:CreativeWork
98 https://doi.org/10.1074/jbc.m404486200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048894777
99 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...