Process for increasing the stability of enzymes and stabilized enzymes


Ontology type: sgo:Patent     


Patent Info

DATE

1993-02-03T00:00

AUTHORS

VETTER, ROMAN , Mücke, Ingo , WILKE, DETLEF , AMORY, ANTOINE , AEHLE, WOLFGANG , SOBEK, HARALD , SCHOMBURG, DIETMAR , Clippe, André

ABSTRACT

The stabilisation of enzymes against the destabilising action of ionic surfactants, and enzymes stabilised in this way are described. For the stabilisation, DNA sequences which code for the enzymes are modified by directed mutation in defined positions which correlate with defined surface regions of the enzyme in such a way that the codon in which the mutation is located now codes for an amino acid which differs from the original amino acid. More... »

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