Chimaeric influenza-HIV vaccine


Ontology type: sgo:Patent     


Patent Info

DATE

1992-07-01T00:00

AUTHORS

TOLMAN, RICHARD L. , UNDERWOOD, DENNIS J.

ABSTRACT

The exposed and highly immunogenic A-antigenic loop of influenza hemagglutinin (HA) is homologous with a Principal Neutralizing Determinant (PND) present on the Human Immunodeficiency Virus' (HIV) envelope glycoprotein, gp120. Inoculation of a mammal with a killed or attenuated virus, or purified HA protein, modified so as to convert the HA A-antigenic site into an HIV PND, produces the usual strong response to the HA site A, but the antibody produced is specific to the hemagglutinin-HIV PND chimaera, and is useful to neutralize HIV. More... »

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