Translesion synthesis


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Translesion synthesis

DESCRIPTION

Translesion synthesis can bypass a replication block caused by various DNA damage. Specialised translesion synthesis DNA polymerases can replicate DNA over such lesions to resume publication but the enzymes are error prone.

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "id": "http://scigraph.springernature.com/ontologies/subjects/translesion-synthesis", 
    "rdfs:label": "Translesion synthesis", 
    "sdDataset": "onto_subjects", 
    "skos:broader": [
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/dna-replication"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/dna-damage-and-repair"
      }
    ], 
    "skos:definition": [
      {
        "@language": "en", 
        "@value": "Translesion synthesis can bypass a replication block caused by various DNA damage. Specialised translesion synthesis DNA polymerases can replicate DNA over such lesions to resume publication but the enzymes are error prone."
      }
    ], 
    "skos:inScheme": [
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/"
      }
    ], 
    "skos:prefLabel": [
      {
        "@language": "en", 
        "@value": "Translesion synthesis"
      }
    ], 
    "type": [
      "http://ns.nature.com/terms/Subject", 
      "http://www.w3.org/2004/02/skos/core#Concept"
    ]
  }, 
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "id": "http://scigraph.springernature.com/ontologies/subjects/dna-replication", 
    "rdfs:label": "DNA replication", 
    "sdDataset": "onto_subjects", 
    "skos:altLabel": [
      {
        "@language": "en", 
        "@value": "Autonomous Replications"
      }, 
      {
        "@language": "en", 
        "@value": "Autonomous Replication"
      }, 
      {
        "@language": "en", 
        "@value": "DNA Replications"
      }
    ], 
    "skos:broader": [
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/molecular-biology"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/cell-division"
      }
    ], 
    "skos:definition": [
      {
        "@language": "en", 
        "@value": "DNA replication is the biological process by which an exact copy of a deoxyribonucleic acid (DNA) molecule is created and it is the basis for biological inheritance. Each of the two strands of the DNA molecule acts as a template for the synthesis of a complementary strand."
      }
    ], 
    "skos:inScheme": [
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/"
      }
    ], 
    "skos:narrower": [
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/origin-selection"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/dna-synthesis"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/stalled-forks"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/translesion-synthesis"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/fragile-sites"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/replisome"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/origin-firing"
      }
    ], 
    "skos:prefLabel": [
      {
        "@language": "en", 
        "@value": "DNA replication"
      }
    ], 
    "type": [
      "http://ns.nature.com/terms/Subject", 
      "http://www.w3.org/2004/02/skos/core#Concept"
    ]
  }, 
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "id": "http://scigraph.springernature.com/ontologies/subjects/dna-damage-and-repair", 
    "rdfs:label": "DNA damage and repair", 
    "sdDataset": "onto_subjects", 
    "skos:altLabel": [
      {
        "@language": "en", 
        "@value": "Excision Repair"
      }, 
      {
        "@language": "en", 
        "@value": "DNA Damage"
      }, 
      {
        "@language": "en", 
        "@value": "Genotoxic Stresses"
      }, 
      {
        "@language": "en", 
        "@value": "Genotoxic Stress"
      }, 
      {
        "@language": "en", 
        "@value": "Nucleotide Excision Repair"
      }, 
      {
        "@language": "en", 
        "@value": "DNA Injury"
      }, 
      {
        "@language": "en", 
        "@value": "Excision Repairs"
      }, 
      {
        "@language": "en", 
        "@value": "Nucleotide Excision Repairs"
      }, 
      {
        "@language": "en", 
        "@value": "DNA Damages"
      }, 
      {
        "@language": "en", 
        "@value": "Base Excision Repair"
      }, 
      {
        "@language": "en", 
        "@value": "Base Excision Repairs"
      }, 
      {
        "@language": "en", 
        "@value": "DNA Injuries"
      }
    ], 
    "skos:broader": [
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/molecular-biology"
      }
    ], 
    "skos:definition": [
      {
        "@language": "en", 
        "@value": "DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce mutations if not corrected, multiple cellular DNA repair mechanisms exist to remove damaged regions of chromosomes to prevent these potentially deleterious effects."
      }
    ], 
    "skos:inScheme": [
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/"
      }
    ], 
    "skos:narrower": [
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/dna-adducts"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/double-strand-dna-breaks"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/single-strand-dna-breaks"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/base-excision-repair"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/non-homologous-end-joining"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/dna-damage-checkpoints"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/nucleotide-excision-repair"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/dna-mismatch-repair"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/homologous-recombination"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/dna-damage-response"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/translesion-synthesis"
      }
    ], 
    "skos:prefLabel": [
      {
        "@language": "en", 
        "@value": "DNA damage and repair"
      }
    ], 
    "type": [
      "http://ns.nature.com/terms/Subject", 
      "http://www.w3.org/2004/02/skos/core#Concept"
    ]
  }, 
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "id": "http://www.w3.org/2004/02/skos/core#Concept", 
    "rdfs:subClassOf": [
      {
        "id": "http://www.w3.org/2004/02/skos/core#Concept"
      }, 
      {
        "id": "http://www.w3.org/2000/01/rdf-schema#Resource"
      }
    ], 
    "sdDataset": "for_codes", 
    "type": [
      "http://www.w3.org/2000/01/rdf-schema#Resource", 
      "http://www.w3.org/2000/01/rdf-schema#Class"
    ]
  }, 
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "dcterms:description": [
      {
        "@language": "en", 
        "@value": "The Nature Subjects Taxonomy is a polyhierarchical categorization of scholarly subject areas which are used for the indexing of content by Springer Nature."
      }
    ], 
    "dcterms:title": [
      {
        "@language": "en", 
        "@value": "Nature Subjects Taxonomy"
      }
    ], 
    "id": "http://scigraph.springernature.com/ontologies/subjects/", 
    "sdDataset": "onto_subjects", 
    "skos:hasTopConcept": [
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/physical-sciences"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/DEPRECATED"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/business-and-commerce"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/humanities"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/social-science"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/health-sciences"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/scientific-community-and-society"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/earth-and-environmental-sciences"
      }, 
      {
        "id": "http://scigraph.springernature.com/ontologies/subjects/biological-sciences"
      }
    ], 
    "type": [
      "http://www.w3.org/2004/02/skos/core#ConceptScheme"
    ]
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/ontologies/subjects/translesion-synthesis'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/ontologies/subjects/translesion-synthesis'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/ontologies/subjects/translesion-synthesis'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/ontologies/subjects/translesion-synthesis'


 

This table displays all metadata directly associated to this object as RDF triples.

78 TRIPLES      8 PREDICATES      11 URIs      4 LITERALS

Subject Predicate Object
1 sg:ontologies/subjects/translesion-synthesis sgo:license sg:explorer/license/
2 sgo:sdDataset onto_subjects
3 rdf:type npg:Subject
4 skos:Concept
5 rdfs:label Translesion synthesis
6 skos:broader sg:ontologies/subjects/dna-damage-and-repair
7 sg:ontologies/subjects/dna-replication
8 skos:definition Translesion synthesis can bypass a replication block caused by various DNA damage. Specialised translesion synthesis DNA polymerases can replicate DNA over such lesions to resume publication but the enzymes are error prone.
9 skos:inScheme sg:ontologies/subjects/
10 skos:prefLabel Translesion synthesis
11 sg:ontologies/subjects/ dcterms:description The Nature Subjects Taxonomy is a polyhierarchical categorization of scholarly subject areas which are used for the indexing of content by Springer Nature.
12 dcterms:title Nature Subjects Taxonomy
13 sgo:sdDataset onto_subjects
14 rdf:type skos:ConceptScheme
15 skos:hasTopConcept sg:ontologies/subjects/DEPRECATED
16 sg:ontologies/subjects/biological-sciences
17 sg:ontologies/subjects/business-and-commerce
18 sg:ontologies/subjects/earth-and-environmental-sciences
19 sg:ontologies/subjects/health-sciences
20 sg:ontologies/subjects/humanities
21 sg:ontologies/subjects/physical-sciences
22 sg:ontologies/subjects/scientific-community-and-society
23 sg:ontologies/subjects/social-science
24 sg:ontologies/subjects/dna-damage-and-repair sgo:sdDataset onto_subjects
25 rdf:type npg:Subject
26 skos:Concept
27 rdfs:label DNA damage and repair
28 skos:altLabel Base Excision Repair
29 Base Excision Repairs
30 DNA Damage
31 DNA Damages
32 DNA Injuries
33 DNA Injury
34 Excision Repair
35 Excision Repairs
36 Genotoxic Stress
37 Genotoxic Stresses
38 Nucleotide Excision Repair
39 Nucleotide Excision Repairs
40 skos:broader sg:ontologies/subjects/molecular-biology
41 skos:definition DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce mutations if not corrected, multiple cellular DNA repair mechanisms exist to remove damaged regions of chromosomes to prevent these potentially deleterious effects.
42 skos:inScheme sg:ontologies/subjects/
43 skos:narrower sg:ontologies/subjects/base-excision-repair
44 sg:ontologies/subjects/dna-adducts
45 sg:ontologies/subjects/dna-damage-checkpoints
46 sg:ontologies/subjects/dna-damage-response
47 sg:ontologies/subjects/dna-mismatch-repair
48 sg:ontologies/subjects/double-strand-dna-breaks
49 sg:ontologies/subjects/homologous-recombination
50 sg:ontologies/subjects/non-homologous-end-joining
51 sg:ontologies/subjects/nucleotide-excision-repair
52 sg:ontologies/subjects/single-strand-dna-breaks
53 sg:ontologies/subjects/translesion-synthesis
54 skos:prefLabel DNA damage and repair
55 sg:ontologies/subjects/dna-replication sgo:sdDataset onto_subjects
56 rdf:type npg:Subject
57 skos:Concept
58 rdfs:label DNA replication
59 skos:altLabel Autonomous Replication
60 Autonomous Replications
61 DNA Replications
62 skos:broader sg:ontologies/subjects/cell-division
63 sg:ontologies/subjects/molecular-biology
64 skos:definition DNA replication is the biological process by which an exact copy of a deoxyribonucleic acid (DNA) molecule is created and it is the basis for biological inheritance. Each of the two strands of the DNA molecule acts as a template for the synthesis of a complementary strand.
65 skos:inScheme sg:ontologies/subjects/
66 skos:narrower sg:ontologies/subjects/dna-synthesis
67 sg:ontologies/subjects/fragile-sites
68 sg:ontologies/subjects/origin-firing
69 sg:ontologies/subjects/origin-selection
70 sg:ontologies/subjects/replisome
71 sg:ontologies/subjects/stalled-forks
72 sg:ontologies/subjects/translesion-synthesis
73 skos:prefLabel DNA replication
74 skos:Concept sgo:sdDataset for_codes
75 rdf:type rdfs:Class
76 rdfs:Resource
77 rdfs:subClassOf rdfs:Resource
78 skos:Concept
 




Preview window. Press ESC to close (or click here)


...