Target validation


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Target validation

DESCRIPTION

Target validation is the process by which the predicted molecular target – for example protein or nucleic acid – of a small molecule is verified. Target validation can include: determining the structure-activity-relationship of analogs of the small molecule; generating a drug-resistant mutant of the presumed target; knockdown or overexpression of the presumed target; and monitoring the known signalling systems downstream of the presumed target.

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