Stem cells


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Stem cells

DESCRIPTION

Stem cells are cells that have the capacity to self-renew by dividing and to develop into more mature, specialised cells. Stem cells can be unipotent, multipotent, pluripotent or totipotent, depending on the number of cell types to which they can give rise.

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This table displays all metadata directly associated to this object as RDF triples.

404 TRIPLES      10 PREDICATES      44 URIs      13 LITERALS

Subject Predicate Object
1 sg:ontologies/subjects/stem-cells sgo:license sg:explorer/license/
2 sgo:sdDataset onto_subjects
3 rdf:type npg:Subject
4 skos:Concept
5 rdfs:label Stem cells
6 skos:altLabel Colony Forming Unit
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8 Colony-Forming Unit
9 Colony-Forming Units
10 Mother Cell
11 Mother Cells
12 Progenitor Cell
13 Progenitor Cells
14 Stem Cell
15 skos:broader sg:ontologies/subjects/biological-sciences
16 sg:ontologies/subjects/developmental-biology
17 skos:definition Stem cells are cells that have the capacity to self-renew by dividing and to develop into more mature, specialised cells. Stem cells can be unipotent, multipotent, pluripotent or totipotent, depending on the number of cell types to which they can give rise.
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43 skos:prefLabel Stem cells
44 sg:ontologies/subjects/ dcterms:description The Nature Subjects Taxonomy is a polyhierarchical categorization of scholarly subject areas which are used for the indexing of content by Springer Nature.
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62 Somatic stem cell
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64 skos:definition Adult stem cells are cells in the adult that can both self-renew by dividing and give rise to more specialised cell types present in the tissue in which they reside. They serve to maintain and repair the tissue.
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84 sg:ontologies/subjects/stem-cells
85 skos:definition Ageing is the process during which structural and functional changes accumulate in an organism as a result of the passage of time. The changes manifest as a decline from the organism’s peak fertility and physiological functions until death.
86 skos:inScheme sg:ontologies/subjects/
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127 sg:ontologies/subjects/cancer-stem-cells sgo:sdDataset onto_subjects
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132 Neoplastic Colony Forming Units
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139 skos:broader sg:ontologies/subjects/cancer
140 sg:ontologies/subjects/stem-cells
141 skos:definition Cancer stem cells are rare immortal cells within a tumour that can both self-renew by dividing and give rise to many cell types that constitute the tumour, and can therefore form tumours. Such cells have been found in various types of human tumours and might be attractive targets for cancer treatment.
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149 skos:definition Developmental biology is the field of biology that studies the processes by which multicellular organisms grow and develop, controlled by their genes. Knowledge of normal developmental processes can aid in the understanding of developmental abnormalities and other conditions such as cancer.
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157 sg:ontologies/subjects/cell-proliferation
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168 sg:ontologies/subjects/lymphangiogenesis
169 sg:ontologies/subjects/morphogenesis
170 sg:ontologies/subjects/neurogenesis
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172 sg:ontologies/subjects/pattern-formation
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174 sg:ontologies/subjects/reprogramming
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177 sg:ontologies/subjects/stem-cell-niche
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179 sg:ontologies/subjects/transdifferentiation
180 skos:prefLabel Developmental biology
181 sg:ontologies/subjects/embryonic-germ-cells sgo:sdDataset onto_subjects
182 rdf:type npg:Subject
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184 rdfs:label Embryonic germ cells
185 skos:altLabel Gametes
186 Germ Cell
187 Germ Cells
188 Germ Line
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190 Germ Lines
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193 skos:broader sg:ontologies/subjects/pluripotent-stem-cells
194 sg:ontologies/subjects/stem-cells
195 skos:definition Embryonic germ cells are the cells in the embryo that give rise to the reproductive cells – gametes – of sexually reproducing organisms. In animals, male gametes are sperm cells and female gametes are egg cells, also known as ova.
196 skos:inScheme sg:ontologies/subjects/
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202 skos:altLabel Embryonic Stem Cell
203 skos:broader sg:ontologies/subjects/pluripotent-stem-cells
204 sg:ontologies/subjects/stem-cells
205 skos:definition Embryonic stem cells are pluripotent cells isolated from the inner cell mass of a blastocyst, the early mammalian embryo that implants into the uterus. Embryonic stem cells self-renew by dividing and can differentiate into any specialised cell of the body, but not extra-embryonic tissues such as the placenta.
206 skos:inScheme sg:ontologies/subjects/
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208 sg:ontologies/subjects/epigenetic-memory sgo:sdDataset onto_subjects
209 rdf:type npg:Subject
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211 rdfs:label Epigenetic memory
212 skos:broader sg:ontologies/subjects/developmental-biology
213 sg:ontologies/subjects/stem-cells
214 skos:definition The epigenetic memory of a cell defines the set of modifications to the cell's deoxyribonucleic acid (DNA) that do not alter the DNA sequence, and have been inherited from the cell from which it descends. Such modifications can alter gene expression and therefore the properties and behaviour of the cell.
215 skos:inScheme sg:ontologies/subjects/
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225 Hematopoietic Stem Cell
226 skos:broader sg:ontologies/subjects/adult-stem-cells
227 sg:ontologies/subjects/erythropoiesis
228 sg:ontologies/subjects/stem-cells
229 skos:definition Haematopoietic stem cells are progenitor cells that have the ability to both generate all types of blood cells, including those of the myeloid and lymphoid lineages, and to replace themselves. In adults, they mainly reside in the bone marrow.
230 skos:inScheme sg:ontologies/subjects/
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236 skos:altLabel Cardiac Stem Cells
237 skos:broader sg:ontologies/subjects/adult-stem-cells
238 sg:ontologies/subjects/stem-cells
239 skos:definition Heart stem or progenitor cells are multipotent cells residing in the adult mammalian heart that are capable of self-renewing and generating coronary vessels and heart muscle cells called cardiomyocytes. Heart stem cells can contribute to new cardiomyocyte formation following experimental myocardial infarction in mice.
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246 skos:altLabel Intestinal epithelial stem cell
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248 sg:ontologies/subjects/stem-cells
249 skos:definition Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and differentiate into the specialised cells of the intestinal epithelium, which renews throughout life.
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259 sg:ontologies/subjects/stem-cells
260 skos:definition Mammary stem cells are multipotent adult stem cells that reside in the mammary gland, can self-renew by dividing and can differentiate into all specialised mammary epithelial cells. Mammary stem cells drive the development of the mammary gland during puberty and are responsible for its expansion during pregnancy.
261 skos:inScheme sg:ontologies/subjects/
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271 skos:broader sg:ontologies/subjects/adult-stem-cells
272 sg:ontologies/subjects/stem-cells
273 skos:definition Mesenchymal stem cells are multipotent adult stem cells that are present in multiple tissues, including umbilical cord, bone marrow and fat tissue. Mesenchymal stem cells can self-renew by dividing and can differentiate into multiple tissues including bone, cartilage, muscle and fat cells, and connective tissue.
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282 skos:definition Multipotent stem cells are cells that have the capacity to self-renew by dividing and to develop into multiple specialised cell types present in a specific tissue or organ. Most adult stem cells are multipotent stem cells.
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291 skos:definition Muscle stem cells are adult stem cells, present in skeletal muscle tissue, which can self-renew and are capable of giving rise to skeletal muscle cells. These stem cells are activated in response to muscle injury to regenerate damaged muscle tissue.
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302 skos:definition Neural stem cells are multipotent adult stem cells present in the adult central nervous system that can self-renew, and give rise to new neurons and supporting cells called glial cells. Activation of neural stem cells or their transplantation into areas of central nervous system injury can lead to regeneration in animal models.
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322 skos:definition Quiescence is the reversible state of a cell in which it does not divide but retains the ability to re-enter cell proliferation. Some adult stem cells are maintained in a quiescent state and can be rapidly activated when stimulated, for example by injury to the tissue in which they reside.
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331 skos:definition Regeneration is the process by which lost or damaged tissues, organs or limbs are re-formed from the remaining tissue. During regeneration, adult stem cells and/or progenitor cells differentiate to replace the missing tissue, although in some instances differentiated cells can also participate in the regeneration by proliferation or transdifferentiation.
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357 sg:ontologies/subjects/stem-cells
358 skos:definition Skin stem cells are multipotent adult stem cells present in the adult skin, which can self-renew and differentiate into different cell lineages of the skin. Skin stem cells are active during skin renewal, which occurs throughout life, and in skin repair after injury.
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366 skos:definition Stem-cell differentiation is the process by which a more specialised cell is formed from a stem cell, leading to loss of some of the stem cell's developmental potential. Stem-cell differentiation occurs during development of an organism to produce new specialised cells, and also in adults to replenish cells that are lost.
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373 skos:altLabel Stem Cell Niches
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375 sg:ontologies/subjects/stem-cells
376 skos:definition A stem-cell niche is an area of a tissue that provides a specific microenvironment, in which stem cells are present in an undifferentiated and self-renewable state. Cells of the stem-cell niche interact with the stem cells to maintain them or promote their differentiation.
377 skos:inScheme sg:ontologies/subjects/
378 skos:prefLabel Stem-cell niche
379 sg:ontologies/subjects/totipotent-stem-cells sgo:sdDataset onto_subjects
380 rdf:type npg:Subject
381 skos:Concept
382 rdfs:label Totipotent stem cells
383 skos:altLabel Totipotent Stem Cell
384 skos:broader sg:ontologies/subjects/stem-cells
385 skos:definition Totipotent stem cells are cells that have the capacity to self-renew by dividing and to develop into the three primary germ cell layers of the early embryo and into extra-embryonic tissues such as the placenta. A fertilised egg is a totipotent stem cell and as such can develop into any specialised cell found in the organism.
386 skos:inScheme sg:ontologies/subjects/
387 skos:prefLabel Totipotent stem cells
388 sg:ontologies/subjects/transdifferentiation sgo:sdDataset onto_subjects
389 rdf:type npg:Subject
390 skos:Concept
391 rdfs:label Transdifferentiation
392 skos:altLabel Cell Transdifferentiation
393 Cell Transdifferentiations
394 Lineage conversion
395 skos:broader sg:ontologies/subjects/developmental-biology
396 sg:ontologies/subjects/stem-cells
397 skos:definition Transdifferentiation is the conversion of a cell type present in one tissue or organ into a cell type from another tissue or organ without going through a pluripotent cell state. Transdifferentiation between some cell types can occur naturally in response to injury and can be induced experimentally.
398 skos:inScheme sg:ontologies/subjects/
399 skos:prefLabel Transdifferentiation
400 skos:Concept sgo:sdDataset for_codes
401 rdf:type rdfs:Class
402 rdfs:Resource
403 rdfs:subClassOf rdfs:Resource
404 skos:Concept
 




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