Nucleic-acid therapeutics


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Nucleic-acid therapeutics

DESCRIPTION

Nucleic acid therapeutics are based on nucleic acids or closely related chemical compounds. They include antisense oligonucleotides, aptamers and small interfering RNAs, and are typically considered in cases where specific inhibition of the function of a particular gene involved in disease is thought to be therapeutically desirable.

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37 skos:inScheme sg:ontologies/subjects/
38 skos:prefLabel Antagomir and RNA sponge
39 sg:ontologies/subjects/antisense-oligonucleotide-therapy sgo:sdDataset onto_subjects
40 rdf:type npg:Subject
41 skos:Concept
42 rdfs:label Antisense oligonucleotide therapy
43 skos:altLabel Anti Sense Oligonucleotides
44 Anti-Sense Oligonucleotides
45 Antisense Oligonucleotides
46 skos:broader sg:ontologies/subjects/biologics
47 sg:ontologies/subjects/nucleic-acid-therapeutics
48 skos:inScheme sg:ontologies/subjects/
49 skos:prefLabel Antisense oligonucleotide therapy
50 sg:ontologies/subjects/biologics sgo:sdDataset onto_subjects
51 rdf:type npg:Subject
52 skos:Concept
53 rdfs:label Biologics
54 skos:altLabel Biologic Products
55 Biologic medicinal product
56 Biologic medicine
57 Biological
58 Biological Products
59 Biopharmaceutical
60 Natural Products
61 skos:broader sg:ontologies/subjects/biotechnology
62 sg:ontologies/subjects/drug-discovery
63 skos:definition A biologic is a therapeutic substance that is produced through a biological process (often involving biotechnology methods), rather than chemical synthesis (as for traditional pharmaceuticals). Types of biologic include antibody therapies, vaccines, gene therapies and cell therapies.
64 skos:inScheme sg:ontologies/subjects/
65 skos:narrower sg:ontologies/subjects/antagomir-and-rna-sponge
66 sg:ontologies/subjects/antibody-fragment-therapy
67 sg:ontologies/subjects/antibody-therapy
68 sg:ontologies/subjects/antisense-oligonucleotide-therapy
69 sg:ontologies/subjects/cell-therapies
70 sg:ontologies/subjects/dna-vaccines
71 sg:ontologies/subjects/gene-therapy
72 sg:ontologies/subjects/locked-nucleic-acid
73 sg:ontologies/subjects/meganucleases
74 sg:ontologies/subjects/nucleic-acid-therapeutics
75 sg:ontologies/subjects/peptide-nucleic-acid-oligo
76 sg:ontologies/subjects/recombinant-peptide-therapy
77 sg:ontologies/subjects/recombinant-protein-therapy
78 sg:ontologies/subjects/recombinant-vaccine
79 sg:ontologies/subjects/rna-vaccines
80 sg:ontologies/subjects/sirnas
81 sg:ontologies/subjects/tal-effector-nuclease
82 sg:ontologies/subjects/triplex-oligo
83 sg:ontologies/subjects/zinc-finger-nuclease
84 skos:prefLabel Biologics
85 sg:ontologies/subjects/biotechnology sgo:sdDataset onto_subjects
86 rdf:type npg:Subject
87 skos:Concept
88 rdfs:label Biotechnology
89 skos:altLabel Biotechnologies
90 skos:broader sg:ontologies/subjects/biological-sciences
91 skos:definition Biotechnology is a broad discipline in which biological processes, organisms, cells or cellular components are exploited to develop new technologies. New tools and products developed by biotechnologists are useful in research, agriculture, industry and the clinic.
92 skos:inScheme sg:ontologies/subjects/
93 skos:narrower sg:ontologies/subjects/animal-biotechnology
94 sg:ontologies/subjects/applied-immunology
95 sg:ontologies/subjects/assay-systems
96 sg:ontologies/subjects/biologics
97 sg:ontologies/subjects/biomaterials
98 sg:ontologies/subjects/biomimetics
99 sg:ontologies/subjects/cell-delivery
100 sg:ontologies/subjects/environmental-biotechnology
101 sg:ontologies/subjects/expression-systems
102 sg:ontologies/subjects/functional-genomics
103 sg:ontologies/subjects/gene-delivery
104 sg:ontologies/subjects/gene-therapy
105 sg:ontologies/subjects/genomics
106 sg:ontologies/subjects/industrial-microbiology
107 sg:ontologies/subjects/metabolic-engineering
108 sg:ontologies/subjects/metabolomics
109 sg:ontologies/subjects/molecular-engineering
110 sg:ontologies/subjects/nanobiotechnology
111 sg:ontologies/subjects/nucleic-acid-therapeutics
112 sg:ontologies/subjects/oligo-delivery
113 sg:ontologies/subjects/peptide-delivery
114 sg:ontologies/subjects/plant-biotechnology
115 sg:ontologies/subjects/protein-delivery
116 sg:ontologies/subjects/proteomics
117 sg:ontologies/subjects/regenerative-medicine
118 sg:ontologies/subjects/sequencing
119 sg:ontologies/subjects/stem-cell-biotechnology
120 sg:ontologies/subjects/tissue-engineering
121 skos:prefLabel Biotechnology
122 sg:ontologies/subjects/locked-nucleic-acid sgo:sdDataset onto_subjects
123 rdf:type npg:Subject
124 skos:Concept
125 rdfs:label Locked nucleic acid
126 skos:altLabel Inaccessible RNA
127 skos:broader sg:ontologies/subjects/biologics
128 sg:ontologies/subjects/nucleic-acid-therapeutics
129 skos:definition In locked nucleic acids (LNAs), the ribose ring is locked in a particular conformation by the introduction of a 2′-O-,4′-C methylene bridge, which increases the affinity for complementary RNA or DNA. LNAs are used to increase the sensitivity and specificity of molecular biology tools such as DNA microarrays and LNA-based oligonucleotides are being developed as antisense therapies.
130 skos:inScheme sg:ontologies/subjects/
131 skos:prefLabel Locked nucleic acid
132 sg:ontologies/subjects/peptide-nucleic-acid-oligo sgo:sdDataset onto_subjects
133 rdf:type npg:Subject
134 skos:Concept
135 rdfs:label Peptide nucleic acid oligo
136 skos:broader sg:ontologies/subjects/biologics
137 sg:ontologies/subjects/nucleic-acid-therapeutics
138 skos:definition Peptide nucleic acids are synthetic polymers that mimic the structure of DNA or RNA. PNAs are used in various molecular biology techniques involving specific recognition of a complementary DNA or RNA strand and have been investigated as the basis for diagnostics and antisense therapies.
139 skos:inScheme sg:ontologies/subjects/
140 skos:prefLabel Peptide nucleic acid oligo
141 sg:ontologies/subjects/rnai-therapy sgo:sdDataset onto_subjects
142 rdf:type npg:Subject
143 skos:Concept
144 rdfs:label RNAi therapy
145 skos:broader sg:ontologies/subjects/nucleic-acid-therapeutics
146 skos:inScheme sg:ontologies/subjects/
147 skos:prefLabel RNAi therapy
148 sg:ontologies/subjects/triplex-oligo sgo:sdDataset onto_subjects
149 rdf:type npg:Subject
150 skos:Concept
151 rdfs:label Triplex-forming oligonucleotide
152 skos:altLabel Triplex oligo
153 skos:broader sg:ontologies/subjects/biologics
154 sg:ontologies/subjects/nucleic-acid-therapeutics
155 skos:definition Triplex-forming oligonucleotides bind in the major groove of duplex DNA in a sequence-specific manner through the formation of hydrogen bonds. They can be used to inhibit the expression of particular genes.
156 skos:inScheme sg:ontologies/subjects/
157 skos:prefLabel Triplex-forming oligonucleotide
158 skos:Concept sgo:sdDataset for_codes
159 rdf:type rdfs:Class
160 rdfs:Resource
161 rdfs:subClassOf rdfs:Resource
162 skos:Concept
 




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