Medicinal chemistry


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Medicinal chemistry

DESCRIPTION

Medicinal chemistry deals with the design, optimization and development of chemical compounds for use as drugs. It is inherently a multidisciplinary topic — beginning with the synthesis of potential drugs followed by studies investigating their interactions with biological targets to understand the medicinal effects of the drug, its metabolism and side-effects.

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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/ontologies/subjects/medicinal-chemistry'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/ontologies/subjects/medicinal-chemistry'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/ontologies/subjects/medicinal-chemistry'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/ontologies/subjects/medicinal-chemistry'


 

This table displays all metadata directly associated to this object as RDF triples.

227 TRIPLES      10 PREDICATES      26 URIs      8 LITERALS

Subject Predicate Object
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12 skos:definition Medicinal chemistry deals with the design, optimization and development of chemical compounds for use as drugs. It is inherently a multidisciplinary topic — beginning with the synthesis of potential drugs followed by studies investigating their interactions with biological targets to understand the medicinal effects of the drug, its metabolism and side-effects.
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26 sg:ontologies/subjects/ dcterms:description The Nature Subjects Taxonomy is a polyhierarchical categorization of scholarly subject areas which are used for the indexing of content by Springer Nature.
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73 skos:definition Chemistry is a branch of science that involves the study of the composition, structure and properties of matter. Often known as the central science, it is a creative discipline chiefly concerned with atomic and molecular structure and its change, for instance through chemical reactions.
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114 skos:definition Computational chemistry describes the use of computer modelling and simulation – including ab initio approaches based on quantum chemistry, and empirical approaches – to study the structures and properties of molecules and materials. Computational chemistry is also used to describe the computational techniques aimed at understanding the structure and properties of molecules and materials.
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127 skos:definition Drug delivery describes the method and approach to delivering drugs or pharmaceuticals and other xenobiotics to their site of action within an organism, with the goal of achieving a therapeutic outcome. Issues of pharmacodynamics and pharmacokinetics are important considerations for drug delivery.
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136 skos:definition Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology.
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160 skos:definition Drug discovery and development together are the complete process of identifying a new drug and bringing it to market. Discovery may involve screening of chemical libraries, identification of the active ingredient from a natural remedy or design resulting from an understanding of the target. Development includes studies on microorganisms and animals, clinical trials and ultimately regulatory approval.
161 skos:inScheme sg:ontologies/subjects/
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168 skos:definition Lead optimization is the process by which a drug candidate is designed after an initial lead compound is identified. The process involves iterative rounds of synthesis and characterisation of a potential drug to build up a picture of how chemical structure and activity are related in terms of interactions with its targets and its metabolism.
169 skos:inScheme sg:ontologies/subjects/
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179 skos:definition Pharmacology is a branch of biomedical science, encompassing clinical pharmacology, that is concerned with the effects of drugs/pharmaceuticals and other xenobiotics on living systems, as well as their development and chemical properties.
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220 skos:definition Target validation is the process by which the predicted molecular target – for example protein or nucleic acid – of a small molecule is verified. Target validation can include: determining the structure-activity-relationship of analogs of the small molecule; generating a drug-resistant mutant of the presumed target; knockdown or overexpression of the presumed target; and monitoring the known signalling systems downstream of the presumed target.
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