Locked nucleic acid


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Locked nucleic acid

DESCRIPTION

In locked nucleic acids (LNAs), the ribose ring is locked in a particular conformation by the introduction of a 2′-O-,4′-C methylene bridge, which increases the affinity for complementary RNA or DNA. LNAs are used to increase the sensitivity and specificity of molecular biology tools such as DNA microarrays and LNA-based oligonucleotides are being developed as antisense therapies.

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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/ontologies/subjects/locked-nucleic-acid'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/ontologies/subjects/locked-nucleic-acid'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/ontologies/subjects/locked-nucleic-acid'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/ontologies/subjects/locked-nucleic-acid'


 

This table displays all metadata directly associated to this object as RDF triples.

79 TRIPLES      9 PREDICATES      12 URIs      5 LITERALS

Subject Predicate Object
1 sg:ontologies/subjects/locked-nucleic-acid sgo:license sg:explorer/license/
2 sgo:sdDataset onto_subjects
3 rdf:type npg:Subject
4 skos:Concept
5 rdfs:label Locked nucleic acid
6 skos:altLabel Inaccessible RNA
7 skos:broader sg:ontologies/subjects/biologics
8 sg:ontologies/subjects/nucleic-acid-therapeutics
9 skos:definition In locked nucleic acids (LNAs), the ribose ring is locked in a particular conformation by the introduction of a 2′-O-,4′-C methylene bridge, which increases the affinity for complementary RNA or DNA. LNAs are used to increase the sensitivity and specificity of molecular biology tools such as DNA microarrays and LNA-based oligonucleotides are being developed as antisense therapies.
10 skos:inScheme sg:ontologies/subjects/
11 skos:prefLabel Locked nucleic acid
12 sg:ontologies/subjects/ dcterms:description The Nature Subjects Taxonomy is a polyhierarchical categorization of scholarly subject areas which are used for the indexing of content by Springer Nature.
13 dcterms:title Nature Subjects Taxonomy
14 sgo:sdDataset onto_subjects
15 rdf:type skos:ConceptScheme
16 skos:hasTopConcept sg:ontologies/subjects/DEPRECATED
17 sg:ontologies/subjects/biological-sciences
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36 skos:broader sg:ontologies/subjects/biotechnology
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39 skos:inScheme sg:ontologies/subjects/
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59 skos:prefLabel Biologics
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61 rdf:type npg:Subject
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63 rdfs:label Nucleic-acid therapeutics
64 skos:broader sg:ontologies/subjects/biologics
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75 skos:Concept sgo:sdDataset for_codes
76 rdf:type rdfs:Class
77 rdfs:Resource
78 rdfs:subClassOf rdfs:Resource
79 skos:Concept
 




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