Ion channels


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Ion channels

DESCRIPTION

Ion channels are integral membrane protein assemblies that modulate the flow of ions into and out of a cell or organelle, leading to generation of electrical signals. Opening (gating) of ion channels can occur upon stimulation with ligands such as second messengers, voltage, temperature and mechanical stress. The directionality of channels is dictated by the electrochemical gradient.

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HOW TO GET THIS DATA PROGRAMMATICALLY:

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This table displays all metadata directly associated to this object as RDF triples.

244 TRIPLES      10 PREDICATES      24 URIs      9 LITERALS

Subject Predicate Object
1 sg:ontologies/subjects/ion-channels sgo:license sg:explorer/license/
2 sgo:sdDataset onto_subjects
3 rdf:type npg:Subject
4 skos:Concept
5 rdfs:label Ion channels
6 skos:altLabel Ion Channel
7 Ionic Channel
8 Ionic Channels
9 Membrane Channel
10 Membrane Channels
11 skos:broader sg:ontologies/subjects/biochemistry
12 sg:ontologies/subjects/chemical-biology
13 skos:definition Ion channels are integral membrane protein assemblies that modulate the flow of ions into and out of a cell or organelle, leading to generation of electrical signals. Opening (gating) of ion channels can occur upon stimulation with ligands such as second messengers, voltage, temperature and mechanical stress. The directionality of channels is dictated by the electrochemical gradient.
14 skos:inScheme sg:ontologies/subjects/
15 skos:narrower sg:ontologies/subjects/calcium-channels
16 sg:ontologies/subjects/chloride-channels
17 sg:ontologies/subjects/cyclic-nucleotide-gated-cation-channels
18 sg:ontologies/subjects/ligand-gated-ion-channels
19 sg:ontologies/subjects/porins
20 sg:ontologies/subjects/potassium-channels
21 sg:ontologies/subjects/sodium-channels
22 sg:ontologies/subjects/transient-receptor-potential-channels
23 skos:prefLabel Ion channels
24 sg:ontologies/subjects/ dcterms:description The Nature Subjects Taxonomy is a polyhierarchical categorization of scholarly subject areas which are used for the indexing of content by Springer Nature.
25 dcterms:title Nature Subjects Taxonomy
26 sgo:sdDataset onto_subjects
27 rdf:type skos:ConceptScheme
28 skos:hasTopConcept sg:ontologies/subjects/DEPRECATED
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30 sg:ontologies/subjects/business-and-commerce
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32 sg:ontologies/subjects/health-sciences
33 sg:ontologies/subjects/humanities
34 sg:ontologies/subjects/physical-sciences
35 sg:ontologies/subjects/scientific-community-and-society
36 sg:ontologies/subjects/social-science
37 sg:ontologies/subjects/biochemistry sgo:sdDataset onto_subjects
38 rdf:type npg:Subject
39 skos:Concept
40 rdfs:label Biochemistry
41 skos:altLabel Biological Chemistry
42 skos:broader sg:ontologies/subjects/biological-sciences
43 sg:ontologies/subjects/chemistry
44 skos:definition Biochemistry is the study of the structure and function of biological molecules such as proteins, nucleic acids, carbohydrates and lipids. Biochemistry is also used to describe techniques suited to understanding the interactions and functions of biological molecules, including traditional techniques such as Western blotting, co-immunoprecipitation, and chromatography methods.
45 skos:inScheme sg:ontologies/subjects/
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57 sg:ontologies/subjects/glycomics
58 sg:ontologies/subjects/histocytochemistry
59 sg:ontologies/subjects/hormones
60 sg:ontologies/subjects/immunochemistry
61 sg:ontologies/subjects/ion-channels
62 sg:ontologies/subjects/isoenzymes
63 sg:ontologies/subjects/kinases
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78 skos:prefLabel Biochemistry
79 sg:ontologies/subjects/calcium-channels sgo:sdDataset onto_subjects
80 rdf:type npg:Subject
81 skos:Concept
82 rdfs:label Calcium channels
83 skos:altLabel Calcium Channel
84 Calcium Channel Antagonist Receptor
85 Calcium Channel Antagonist Receptors
86 Calcium Channel Blocker Receptor
87 Calcium Channel Blocker Receptors
88 Calcium Ion Channel
89 Calcium Ion Channels
90 VDCC
91 Voltage Dependent Calcium Channels
92 Voltage-Dependent Calcium Channels
93 skos:broader sg:ontologies/subjects/ion-channels
94 skos:definition Calcium channels are ion channels that are triggered to open by either a change in the voltage across the membrane, which occurs in nerve cells propagating a signal, or by small molecule ligands such as inositol 1,4,5-trisphosphate (Ins3P, IP3). Calcium channels allow calcium to flow into the cell or out of the endoplasmic reticulum.
95 skos:inScheme sg:ontologies/subjects/
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103 skos:definition Chemical biology is the study of the chemicals and chemical reactions involved in biological processes, incorporating the disciplines of bioorganic chemistry, biochemistry, cell biology and pharmacology. Chemicals – including natural small molecules, such as lipids, carbohydrates and metals, or non-natural probe or drug molecules – are used to gain insight into biological problems at a mechanistic level.
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109 sg:ontologies/subjects/chemical-ecology
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123 sg:ontologies/subjects/ion-channels
124 sg:ontologies/subjects/kinases
125 sg:ontologies/subjects/lipidomics
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127 sg:ontologies/subjects/mechanism-of-action
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129 sg:ontologies/subjects/metabolic-pathways
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150 skos:prefLabel Chemical biology
151 sg:ontologies/subjects/chloride-channels sgo:sdDataset onto_subjects
152 rdf:type npg:Subject
153 skos:Concept
154 rdfs:label Chloride channels
155 skos:altLabel Calcium Activated Chloride Channels
156 Calcium-Activated Chloride Channels
157 Chloride Channel
158 Chloride Ion Channel
159 Chloride Ion Channels
160 Chlorine Channels
161 Chlorine channels
162 skos:broader sg:ontologies/subjects/ion-channels
163 skos:definition Chloride channels are ion channels activated by various triggers, including voltage, calcium and pH. Chloride channels allow passage across the membrane of chloride (Cl−) and other anions such as HCO3−, I− and NO3−. Chloride channels are important for setting a cell’s membrane potential and pH, and play a role in maintaining proper cell volume, among other functions.
164 skos:inScheme sg:ontologies/subjects/
165 skos:prefLabel Chloride channels
166 sg:ontologies/subjects/cyclic-nucleotide-gated-cation-channels sgo:sdDataset onto_subjects
167 rdf:type npg:Subject
168 skos:Concept
169 rdfs:label Cyclic nucleotide-gated cation channels
170 skos:altLabel CNG Channel (Rod)
171 Cationic Channel Protein (Rod)
172 Cng Cation Channel
173 Cyclic Nucleotide Gated Cation Channel
174 Cyclic Nucleotide Gated Cation Channels
175 Cyclic Nucleotide Gated Channel
176 Cyclic Nucleotide Gated Ion Channels
177 Cyclic Nucleotide-Gated Cation Channel
178 Cyclic-Nucleotide Gated Channel
179 Cyclic-Nucleotide Gated Ion Channels
180 Hyperpolarization Cyclic Nucleotide Gated Ion Channels
181 Hyperpolarization Cyclic-Nucleotide Gated Ion Channels
182 skos:broader sg:ontologies/subjects/ion-channels
183 skos:definition Cyclic nucleotide-gated cation channels are cation channels controlled from inside the cell by second messengers cAMP and cGMP. They allow for transit of cations sodium, calcium and potassium across cellular membranes. These channels are involved in sensory signalling such as olfaction and vision as well as in cellular development, hormone release and chemotaxis.
184 skos:inScheme sg:ontologies/subjects/
185 skos:prefLabel Cyclic nucleotide-gated cation channels
186 sg:ontologies/subjects/ligand-gated-ion-channels sgo:sdDataset onto_subjects
187 rdf:type npg:Subject
188 skos:Concept
189 rdfs:label Ligand-gated ion channels
190 skos:altLabel Ligand Gated Channels
191 Ligand Gated Ion Channels
192 Ligand-Gated Channels
193 skos:broader sg:ontologies/subjects/ion-channels
194 skos:definition Ligand-gated ion channels are ion channels that are opened or closed (gated) by ligands, generally small molecules such as the second messenger cAMP and neurotransmitters. Ligand-gated ion channels lead to depolarization or hyperpolarization of the membrane. When located at synapses, ligand-gated ion channels convert the neurotransmitter signal from the pre-synaptic neuron into post-synaptic electrical signals.
195 skos:inScheme sg:ontologies/subjects/
196 skos:prefLabel Ligand-gated ion channels
197 sg:ontologies/subjects/porins sgo:sdDataset onto_subjects
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200 rdfs:label Porins
201 skos:altLabel Pore Proteins
202 Scrapie protein
203 Scrapie proteins
204 skos:broader sg:ontologies/subjects/ion-channels
205 skos:definition Porins are bacterial β-strand proteins that form a water-filled β-barrel pore within the outer membrane, either causing a disruption of the membrane or generating a means for transporting molecules such as carbohydrates and amino acids across the membrane. Porins allow for passive diffusion and so are considered membrane transport proteins and channels.
206 skos:inScheme sg:ontologies/subjects/
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208 sg:ontologies/subjects/potassium-channels sgo:sdDataset onto_subjects
209 rdf:type npg:Subject
210 skos:Concept
211 rdfs:label Potassium channels
212 skos:altLabel Potassium Channel
213 Potassium Ion Channel
214 Potassium Ion Channels
215 skos:broader sg:ontologies/subjects/ion-channels
216 skos:definition Potassium channels are ion channels that are selective for passage of potassium ions through the pore. Potassium channels are homotetramers and are crucial for membrane hyperpolarization events after an action potential is fired in neurons. They also regulate cellular processes such as hormone secretion. Potassium channels move potassium ions down their electrochemical gradient.
217 skos:inScheme sg:ontologies/subjects/
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219 sg:ontologies/subjects/sodium-channels sgo:sdDataset onto_subjects
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222 rdfs:label Sodium channels
223 skos:altLabel Sodium Channel
224 Sodium Ion Channel
225 Sodium Ion Channels
226 skos:broader sg:ontologies/subjects/ion-channels
227 skos:definition Sodium channels are ion channels that transport sodium ions across cellular membranes. Sodium channels are generally either ligand-gated or voltage-gated. In voltage-gated sodium channels, as in other voltage-gated channels, positively charged residues in an extracellular domain (S4) are important for channel gating. Sodium channels are important for generating electrical signals in neurons.
228 skos:inScheme sg:ontologies/subjects/
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233 rdfs:label Transient receptor potential channels
234 skos:altLabel TRP Cation Channels
235 TRP Membrane Proteins
236 skos:broader sg:ontologies/subjects/ion-channels
237 skos:definition Transient receptor potential channels (TRP channels) are ion channels that generally transport cations such as sodium, calcium and magnesium non-selectively across the plasma membrane. TRP channels are activated by various stimuli, including small molecules such as capsaicin, tetrahydrocannabinol and menthol, or by mechanical stresses and osmotic pressure.
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