Gene targeting


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Gene targeting

DESCRIPTION

Gene targeting is the process of altering a specific sequence or gene at its location in a genome. Potential modifications include deletion, insertion or replacement of endogenous sequence with alternative sequences. Targeting can be achieved by homologous recombination in some organisms (notably, mice), or with site-directed genome editing nucleases.

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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/ontologies/subjects/gene-targeting'

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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/ontologies/subjects/gene-targeting'

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This table displays all metadata directly associated to this object as RDF triples.

77 TRIPLES      10 PREDICATES      15 URIs      6 LITERALS

Subject Predicate Object
1 sg:ontologies/subjects/gene-targeting sgo:license sg:explorer/license/
2 sgo:sdDataset onto_subjects
3 rdf:type npg:Subject
4 skos:Concept
5 rdfs:label Gene targeting
6 skos:altLabel Gene Targetings
7 Site-directed mutagensis
8 skos:broader sg:ontologies/subjects/genetic-techniques
9 skos:definition Gene targeting is the process of altering a specific sequence or gene at its location in a genome. Potential modifications include deletion, insertion or replacement of endogenous sequence with alternative sequences. Targeting can be achieved by homologous recombination in some organisms (notably, mice), or with site-directed genome editing nucleases.
10 skos:inScheme sg:ontologies/subjects/
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12 sg:ontologies/subjects/tal-effector-nuclease
13 sg:ontologies/subjects/zinc-finger-nuclease
14 skos:prefLabel Gene targeting
15 sg:ontologies/subjects/ dcterms:description The Nature Subjects Taxonomy is a polyhierarchical categorization of scholarly subject areas which are used for the indexing of content by Springer Nature.
16 dcterms:title Nature Subjects Taxonomy
17 sgo:sdDataset onto_subjects
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19 skos:hasTopConcept sg:ontologies/subjects/DEPRECATED
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33 sg:ontologies/subjects/gene-targeting
34 skos:definition CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the double strand break can result in insertion or deletion mutations, while repair pathways can be engineered to introduce specific point mutations or insertions.
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38 rdf:type npg:Subject
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40 rdfs:label Genetic techniques
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53 rdf:type npg:Subject
54 skos:Concept
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56 skos:altLabel TALENs
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58 skos:broader sg:ontologies/subjects/biologics
59 sg:ontologies/subjects/gene-targeting
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