Epigenetics


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Epigenetics

DESCRIPTION

Epigenetics is the study of molecular processes that influence the flow of information between a constant DNA sequence and variable gene expression patterns. This includes investigation of nuclear organization, DNA methylation, histone modification and RNA transcription. Epigenetic processes can result in intergenerational (heritable) effects as well as clonal propagation of cell identity without any mutational change in DNA sequence.

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This table displays all metadata directly associated to this object as RDF triples.

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11 skos:definition Epigenetics is the study of molecular processes that influence the flow of information between a constant DNA sequence and variable gene expression patterns. This includes investigation of nuclear organization, DNA methylation, histone modification and RNA transcription. Epigenetic processes can result in intergenerational (heritable) effects as well as clonal propagation of cell identity without any mutational change in DNA sequence.
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40 sg:ontologies/subjects/dosage-compensation sgo:sdDataset onto_subjects
41 rdf:type npg:Subject
42 skos:Concept
43 rdfs:label Dosage compensation
44 skos:altLabel Dosage Compensation (Genetics)
45 Gene Dosage Compensation
46 Gene Dosage Compensations
47 Genetic Dosage Compensation
48 Genetic Dosage Compensations
49 X Chromosome Hypertranscription
50 X-Chromosome Hypertranscription
51 skos:broader sg:ontologies/subjects/epigenetics
52 skos:definition Dosage compensation is a process that balances expression of sex-linked and autosomal genes in the heterogametic sex. For example, one X chromosome in XX female mammals is randomly inactivated in every cell, and gene transcription levels from the X chromosome of XO or XY male Drosophila is elevated to approximately equal the output of two sex chromosomes in XX females.
53 skos:inScheme sg:ontologies/subjects/
54 skos:prefLabel Dosage compensation
55 sg:ontologies/subjects/gene-silencing sgo:sdDataset onto_subjects
56 rdf:type npg:Subject
57 skos:Concept
58 rdfs:label Gene silencing
59 skos:altLabel Gene Inactivation
60 skos:broader sg:ontologies/subjects/epigenetics
61 skos:definition Gene silencing describes the epigenetic regulation of a gene, at the level of transcription or translation, to prevent gene expression. Mechanisms include DNA methylation, histone modification and RNAi. Methods to silence genes are exploited by researchers to study gene function, and for the development of therapeutics for diseases including cancer, infectious diseases and neurodegenerative disorders.
62 skos:inScheme sg:ontologies/subjects/
63 skos:prefLabel Gene silencing
64 sg:ontologies/subjects/genetics sgo:sdDataset onto_subjects
65 rdf:type npg:Subject
66 skos:Concept
67 rdfs:label Genetics
68 skos:broader sg:ontologies/subjects/biological-sciences
69 skos:definition Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including the molecular structure and function of genes, gene behaviour in the context of a cell or organism (e.g. dominance and epigenetics), gene distribution, and variation and change in populations.
70 skos:inScheme sg:ontologies/subjects/
71 skos:narrower sg:ontologies/subjects/agricultural-genetics
72 sg:ontologies/subjects/animal-breeding
73 sg:ontologies/subjects/behavioural-genetics
74 sg:ontologies/subjects/cancer-genetics
75 sg:ontologies/subjects/cancer-genomics
76 sg:ontologies/subjects/clinical-genetics
77 sg:ontologies/subjects/consanguinity
78 sg:ontologies/subjects/crispr-cas-systems
79 sg:ontologies/subjects/cytogenetics
80 sg:ontologies/subjects/development
81 sg:ontologies/subjects/epigenetics
82 sg:ontologies/subjects/epigenomics
83 sg:ontologies/subjects/eukaryote
84 sg:ontologies/subjects/evolutionary-biology
85 sg:ontologies/subjects/functional-genomics
86 sg:ontologies/subjects/gene-expression
87 sg:ontologies/subjects/gene-regulation
88 sg:ontologies/subjects/genetic-association-study
89 sg:ontologies/subjects/genetic-hybridization
90 sg:ontologies/subjects/genetic-interaction
91 sg:ontologies/subjects/genetic-linkage-study
92 sg:ontologies/subjects/genetic-markers
93 sg:ontologies/subjects/genome
94 sg:ontologies/subjects/genomic-instability
95 sg:ontologies/subjects/genomics
96 sg:ontologies/subjects/genotype
97 sg:ontologies/subjects/haplotypes
98 sg:ontologies/subjects/heritable-quantitative-trait
99 sg:ontologies/subjects/immunogenetics
100 sg:ontologies/subjects/inbreeding
101 sg:ontologies/subjects/medical-genetics
102 sg:ontologies/subjects/microbial-genetics
103 sg:ontologies/subjects/mutation
104 sg:ontologies/subjects/neurodevelopmental-disorders
105 sg:ontologies/subjects/plant-breeding
106 sg:ontologies/subjects/plant-genetics
107 sg:ontologies/subjects/polyploidy
108 sg:ontologies/subjects/population-genetics
109 sg:ontologies/subjects/prokaryote
110 sg:ontologies/subjects/quantitative-trait
111 sg:ontologies/subjects/rna-splicing
112 sg:ontologies/subjects/rnai
113 sg:ontologies/subjects/sequencing
114 skos:prefLabel Genetics
115 sg:ontologies/subjects/imprinting sgo:sdDataset onto_subjects
116 rdf:type npg:Subject
117 skos:Concept
118 rdfs:label Imprinting
119 skos:altLabel Genetic Imprinting
120 Genomic Imprinting
121 Parental Imprinting
122 skos:broader sg:ontologies/subjects/epigenetics
123 skos:definition Imprinting is epigenetic marking of a locus on the basis of its parental origin, which can result in differential expression of the paternal and maternal alleles in specific tissues or developmental stages. These epigenetic marks are established in the germline and can be maintained through mitotic divisions.
124 skos:inScheme sg:ontologies/subjects/
125 skos:prefLabel Imprinting
126 sg:ontologies/subjects/molecular-biology sgo:sdDataset onto_subjects
127 rdf:type npg:Subject
128 skos:Concept
129 rdfs:label Molecular biology
130 skos:altLabel Biochemical Genetic
131 Biochemical Genetics
132 Molecular Genetic
133 Molecular Genetics
134 skos:broader sg:ontologies/subjects/biological-sciences
135 skos:definition Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules – such as nucleic acids and proteins – that carry out the biological processes essential for the cell’s functions and maintenance.
136 skos:inScheme sg:ontologies/subjects/
137 skos:narrower sg:ontologies/subjects/cell-division
138 sg:ontologies/subjects/chromatin
139 sg:ontologies/subjects/chromosomes
140 sg:ontologies/subjects/crispr-cas-systems
141 sg:ontologies/subjects/dna-damage-and-repair
142 sg:ontologies/subjects/dna-metabolism
143 sg:ontologies/subjects/dna-recombination
144 sg:ontologies/subjects/dna-replication
145 sg:ontologies/subjects/epigenetics
146 sg:ontologies/subjects/non-coding-rnas
147 sg:ontologies/subjects/nuclear-organization
148 sg:ontologies/subjects/post-translational-modifications
149 sg:ontologies/subjects/protein-folding
150 sg:ontologies/subjects/proteolysis
151 sg:ontologies/subjects/proteomics
152 sg:ontologies/subjects/riboswitches
153 sg:ontologies/subjects/ribozymes
154 sg:ontologies/subjects/rna-metabolism
155 sg:ontologies/subjects/rnai
156 sg:ontologies/subjects/single-molecule-biophysics
157 sg:ontologies/subjects/transcription
158 sg:ontologies/subjects/transcriptomics
159 sg:ontologies/subjects/translation
160 sg:ontologies/subjects/transposition
161 skos:prefLabel Molecular biology
162 skos:Concept sgo:sdDataset for_codes
163 rdf:type rdfs:Class
164 rdfs:Resource
165 rdfs:subClassOf rdfs:Resource
166 skos:Concept
 




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