Drug discovery


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Drug discovery

DESCRIPTION

Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology.

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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/ontologies/subjects/drug-discovery'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/ontologies/subjects/drug-discovery'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/ontologies/subjects/drug-discovery'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/ontologies/subjects/drug-discovery'


 

This table displays all metadata directly associated to this object as RDF triples.

331 TRIPLES      10 PREDICATES      26 URIs      5 LITERALS

Subject Predicate Object
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26 sg:ontologies/subjects/ dcterms:description The Nature Subjects Taxonomy is a polyhierarchical categorization of scholarly subject areas which are used for the indexing of content by Springer Nature.
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149 skos:prefLabel Biomarkers
150 sg:ontologies/subjects/business-strategy-in-drug-development sgo:sdDataset onto_subjects
151 rdf:type npg:Subject
152 skos:Concept
153 rdfs:label Business strategy in drug development
154 skos:broader sg:ontologies/subjects/drug-discovery
155 skos:inScheme sg:ontologies/subjects/
156 skos:narrower sg:ontologies/subjects/intellectual-property
157 sg:ontologies/subjects/licensing
158 sg:ontologies/subjects/market-analysis
159 sg:ontologies/subjects/mergers-and-acquisitions
160 sg:ontologies/subjects/pharmacoeconomics
161 sg:ontologies/subjects/portfolio-management
162 sg:ontologies/subjects/public-private-partnerships
163 sg:ontologies/subjects/reimbursement
164 skos:prefLabel Business strategy in drug development
165 sg:ontologies/subjects/clinical-trials sgo:sdDataset onto_subjects
166 rdf:type npg:Subject
167 skos:Concept
168 rdfs:label Clinical trials
169 skos:altLabel Clinical Trial
170 skos:broader sg:ontologies/subjects/drug-discovery
171 sg:ontologies/subjects/study-design
172 skos:definition A clinical trial involves the study of the safety, efficacy and/or dosage regimen of a therapeutic intervention (such as a drug) in humans selected according to predetermined criteria of eligibility (such as a defined severity of a specific disease), who are observed for predefined evidence of favourable and unfavourable effects.
173 skos:inScheme sg:ontologies/subjects/
174 skos:narrower sg:ontologies/subjects/adaptive-designs
175 sg:ontologies/subjects/biostatistics
176 sg:ontologies/subjects/phase-0-trials
177 sg:ontologies/subjects/phase-i-trials
178 sg:ontologies/subjects/phase-ii-trials
179 sg:ontologies/subjects/phase-iii-trials
180 sg:ontologies/subjects/phase-iv-trials
181 skos:prefLabel Clinical trials
182 sg:ontologies/subjects/diagnostics sgo:sdDataset onto_subjects
183 rdf:type npg:Subject
184 skos:Concept
185 rdfs:label Diagnostics
186 skos:broader sg:ontologies/subjects/drug-discovery
187 skos:definition A diagnostic is a test (often using a device) used to assist in the diagnosis of a disease, predict the likelihood of a disease developing or progressing, or predict the likelihood of a response to a therapeutic intervention. Examples include tests that screen for particular genetic variants or measure the levels of particular proteins in body fluids.
188 skos:inScheme sg:ontologies/subjects/
189 skos:prefLabel Diagnostics
190 sg:ontologies/subjects/drug-delivery sgo:sdDataset onto_subjects
191 rdf:type npg:Subject
192 skos:Concept
193 rdfs:label Drug delivery
194 skos:broader sg:ontologies/subjects/biomaterials
195 sg:ontologies/subjects/chemical-biology
196 sg:ontologies/subjects/drug-discovery
197 sg:ontologies/subjects/drug-therapy
198 sg:ontologies/subjects/medicinal-chemistry
199 sg:ontologies/subjects/nanomedicine
200 skos:definition Drug delivery describes the method and approach to delivering drugs or pharmaceuticals and other xenobiotics to their site of action within an organism, with the goal of achieving a therapeutic outcome. Issues of pharmacodynamics and pharmacokinetics are important considerations for drug delivery.
201 skos:inScheme sg:ontologies/subjects/
202 skos:prefLabel Drug delivery
203 sg:ontologies/subjects/drug-regulation sgo:sdDataset onto_subjects
204 rdf:type npg:Subject
205 skos:Concept
206 rdfs:label Drug regulation
207 skos:altLabel Drug Control
208 Drug Controls
209 Drug Regulations
210 Drug and Narcotic Control
211 Narcotic Control
212 Narcotic Controls
213 Narcotic and Drug Control
214 Pharmaceutic Policy
215 Pharmaceutical Policies
216 Pharmaceutical Policy
217 skos:broader sg:ontologies/subjects/drug-discovery
218 sg:ontologies/subjects/health-care
219 skos:definition Drug regulation is the control of drug use by international agreement and/or by regulatory authorities such as the US Food and Drug Administration (FDA), the European Medicines Agency (EMA) and the Japanese Pharmaceutical and Medical Devices Agency (PMDA). This includes regulations concerned with the development, approval, manufacturing and marketing of drugs.
220 skos:inScheme sg:ontologies/subjects/
221 skos:prefLabel Drug regulation
222 sg:ontologies/subjects/drug-safety sgo:sdDataset onto_subjects
223 rdf:type npg:Subject
224 skos:Concept
225 rdfs:label Drug safety
226 skos:altLabel Adverse Drug Event
227 Adverse Drug Events
228 Adverse Drug Reaction
229 Adverse Drug Reactions
230 Drug Toxicities
231 Drug Toxicity
232 skos:broader sg:ontologies/subjects/drug-discovery
233 skos:definition Drug safety relates to the potential for adverse effects related to the administration of drugs. Efforts to establish the safely profile of drugs begin early in their development, with in vitro and in vivo toxicity testing, and continue through clinical trials leading up to drug approval and following approval in specific post-marketing studies or general pharmacovigilance efforts.
234 skos:inScheme sg:ontologies/subjects/
235 skos:prefLabel Drug safety
236 sg:ontologies/subjects/drug-screening sgo:sdDataset onto_subjects
237 rdf:type npg:Subject
238 skos:Concept
239 rdfs:label Drug screening
240 skos:altLabel Drug Screenings
241 Preclinical Drug Evaluation
242 Preclinical Drug Evaluations
243 skos:broader sg:ontologies/subjects/drug-discovery
244 skos:definition Drug screening is the process by which potential drugs are identified and optimized before selection of a candidate drug to progress to clinical trials. It can involve screening large libraries of chemicals for a particular biological activity in high-throughput screening assays.
245 skos:inScheme sg:ontologies/subjects/
246 skos:narrower sg:ontologies/subjects/high-throughput-screening
247 sg:ontologies/subjects/phenotypic-screening
248 sg:ontologies/subjects/virtual-screening
249 skos:prefLabel Drug screening
250 sg:ontologies/subjects/medicinal-chemistry sgo:sdDataset onto_subjects
251 rdf:type npg:Subject
252 skos:Concept
253 rdfs:label Medicinal chemistry
254 skos:altLabel Drug Formulation
255 Drug Formulations
256 Pharmaceutic Chemistry
257 Pharmaceutical Chemistry
258 skos:broader sg:ontologies/subjects/chemistry
259 sg:ontologies/subjects/drug-discovery
260 skos:definition Medicinal chemistry deals with the design, optimization and development of chemical compounds for use as drugs. It is inherently a multidisciplinary topic — beginning with the synthesis of potential drugs followed by studies investigating their interactions with biological targets to understand the medicinal effects of the drug, its metabolism and side-effects.
261 skos:inScheme sg:ontologies/subjects/
262 skos:narrower sg:ontologies/subjects/chemical-libraries
263 sg:ontologies/subjects/cheminformatics
264 sg:ontologies/subjects/computational-chemistry
265 sg:ontologies/subjects/drug-delivery
266 sg:ontologies/subjects/drug-discovery-and-development
267 sg:ontologies/subjects/lead-optimization
268 sg:ontologies/subjects/pharmacology
269 sg:ontologies/subjects/screening
270 sg:ontologies/subjects/structure-based-drug-design
271 sg:ontologies/subjects/target-identification
272 sg:ontologies/subjects/target-validation
273 skos:prefLabel Medicinal chemistry
274 sg:ontologies/subjects/pharmaceutics sgo:sdDataset onto_subjects
275 rdf:type npg:Subject
276 skos:Concept
277 rdfs:label Pharmaceutics
278 skos:broader sg:ontologies/subjects/drug-discovery
279 skos:definition Pharmaceutics is the scientific discipline concerned with the process of creating the dosage form (such as a pill for oral administration or a powder for intravenous injection) of a therapeutic that is to be used by patients. It encompasses drug formulation and manufacturing.
280 skos:inScheme sg:ontologies/subjects/
281 skos:prefLabel Pharmaceutics
282 sg:ontologies/subjects/pharmacology sgo:sdDataset onto_subjects
283 rdf:type npg:Subject
284 skos:Concept
285 rdfs:label Pharmacology
286 skos:altLabel Pharmacologies
287 skos:broader sg:ontologies/subjects/chemical-biology
288 sg:ontologies/subjects/drug-discovery
289 sg:ontologies/subjects/medicinal-chemistry
290 skos:definition Pharmacology is a branch of biomedical science, encompassing clinical pharmacology, that is concerned with the effects of drugs/pharmaceuticals and other xenobiotics on living systems, as well as their development and chemical properties.
291 skos:inScheme sg:ontologies/subjects/
292 skos:narrower sg:ontologies/subjects/clinical-pharmacology
293 sg:ontologies/subjects/pharmacodynamics
294 sg:ontologies/subjects/pharmacogenetics
295 sg:ontologies/subjects/pharmacokinetics
296 sg:ontologies/subjects/receptor-pharmacology
297 skos:prefLabel Pharmacology
298 sg:ontologies/subjects/target-identification sgo:sdDataset onto_subjects
299 rdf:type npg:Subject
300 skos:Concept
301 rdfs:label Target identification
302 skos:broader sg:ontologies/subjects/chemical-biology
303 sg:ontologies/subjects/drug-discovery
304 sg:ontologies/subjects/medicinal-chemistry
305 skos:definition Target identification is the process of identifying the direct molecular target – for example protein or nucleic acid – of a small molecule. In clinical pharmacology, target identification is aimed at finding the efficacy target of a drug/pharmaceutical or other xenobiotic. The techniques used may be based on principles of biochemistry, biophysics, genetics, chemical biology or other disciplines.
306 skos:inScheme sg:ontologies/subjects/
307 skos:prefLabel Target identification
308 sg:ontologies/subjects/target-validation sgo:sdDataset onto_subjects
309 rdf:type npg:Subject
310 skos:Concept
311 rdfs:label Target validation
312 skos:broader sg:ontologies/subjects/chemical-biology
313 sg:ontologies/subjects/drug-discovery
314 sg:ontologies/subjects/medicinal-chemistry
315 skos:definition Target validation is the process by which the predicted molecular target – for example protein or nucleic acid – of a small molecule is verified. Target validation can include: determining the structure-activity-relationship of analogs of the small molecule; generating a drug-resistant mutant of the presumed target; knockdown or overexpression of the presumed target; and monitoring the known signalling systems downstream of the presumed target.
316 skos:inScheme sg:ontologies/subjects/
317 skos:prefLabel Target validation
318 sg:ontologies/subjects/toxicology sgo:sdDataset onto_subjects
319 rdf:type npg:Subject
320 skos:Concept
321 rdfs:label Toxicology
322 skos:altLabel Toxinology
323 skos:broader sg:ontologies/subjects/drug-discovery
324 skos:definition Toxicology is the scientific discipline concerned with the detection, evaluation and prevention of the toxic effects of substances that humans are exposed to. It has a key role in the development of new drugs, which are evaluated for potential toxic effects in preclinical studies, clinical trials and post-marketing studies with the aim of ensuring that their benefits outweigh their risks.
325 skos:inScheme sg:ontologies/subjects/
326 skos:prefLabel Toxicology
327 skos:Concept sgo:sdDataset for_codes
328 rdf:type rdfs:Class
329 rdfs:Resource
330 rdfs:subClassOf rdfs:Resource
331 skos:Concept
 




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