DNA replication


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

DNA replication

DESCRIPTION

DNA replication is the biological process by which an exact copy of a deoxyribonucleic acid (DNA) molecule is created and it is the basis for biological inheritance. Each of the two strands of the DNA molecule acts as a template for the synthesis of a complementary strand.

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51 sg:ontologies/subjects/cohesion
52 sg:ontologies/subjects/cytokinesis
53 sg:ontologies/subjects/dna-replication
54 sg:ontologies/subjects/kinetochores
55 sg:ontologies/subjects/meiosis
56 sg:ontologies/subjects/mitosis
57 sg:ontologies/subjects/mitotic-spindle
58 skos:prefLabel Cell division
59 sg:ontologies/subjects/dna-synthesis sgo:sdDataset onto_subjects
60 rdf:type npg:Subject
61 skos:Concept
62 rdfs:label DNA synthesis
63 skos:altLabel Autonomous Replication
64 Autonomous Replications
65 DNA Replication
66 DNA Replications
67 skos:broader sg:ontologies/subjects/dna-replication
68 skos:definition DNA synthesis is the biological process by which a deoxyribonucleic acid (DNA) molecule is created. In the cell, each of the two strands of the DNA molecule acts as a template for the synthesis of a complementary strand.
69 skos:inScheme sg:ontologies/subjects/
70 skos:prefLabel DNA synthesis
71 sg:ontologies/subjects/fragile-sites sgo:sdDataset onto_subjects
72 rdf:type npg:Subject
73 skos:Concept
74 rdfs:label Fragile sites
75 skos:broader sg:ontologies/subjects/dna-replication
76 skos:definition Fragile sites are chromosomal regions that are susceptible to gaps or breaks. Common fragile sites occur in all individuals, are thought to be sensitive to replication stress due to chromosome structure, and are often re-arranged in cancer. Rare fragile sites are caused by nucleotide repeats and are inherited.
77 skos:inScheme sg:ontologies/subjects/
78 skos:prefLabel Fragile sites
79 sg:ontologies/subjects/molecular-biology sgo:sdDataset onto_subjects
80 rdf:type npg:Subject
81 skos:Concept
82 rdfs:label Molecular biology
83 skos:altLabel Biochemical Genetic
84 Biochemical Genetics
85 Molecular Genetic
86 Molecular Genetics
87 skos:broader sg:ontologies/subjects/biological-sciences
88 skos:definition Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules – such as nucleic acids and proteins – that carry out the biological processes essential for the cell’s functions and maintenance.
89 skos:inScheme sg:ontologies/subjects/
90 skos:narrower sg:ontologies/subjects/cell-division
91 sg:ontologies/subjects/chromatin
92 sg:ontologies/subjects/chromosomes
93 sg:ontologies/subjects/crispr-cas-systems
94 sg:ontologies/subjects/dna-damage-and-repair
95 sg:ontologies/subjects/dna-metabolism
96 sg:ontologies/subjects/dna-recombination
97 sg:ontologies/subjects/dna-replication
98 sg:ontologies/subjects/epigenetics
99 sg:ontologies/subjects/non-coding-rnas
100 sg:ontologies/subjects/nuclear-organization
101 sg:ontologies/subjects/post-translational-modifications
102 sg:ontologies/subjects/protein-folding
103 sg:ontologies/subjects/proteolysis
104 sg:ontologies/subjects/proteomics
105 sg:ontologies/subjects/riboswitches
106 sg:ontologies/subjects/ribozymes
107 sg:ontologies/subjects/rna-metabolism
108 sg:ontologies/subjects/rnai
109 sg:ontologies/subjects/single-molecule-biophysics
110 sg:ontologies/subjects/transcription
111 sg:ontologies/subjects/transcriptomics
112 sg:ontologies/subjects/translation
113 sg:ontologies/subjects/transposition
114 skos:prefLabel Molecular biology
115 sg:ontologies/subjects/origin-firing sgo:sdDataset onto_subjects
116 rdf:type npg:Subject
117 skos:Concept
118 rdfs:label Origin firing
119 skos:broader sg:ontologies/subjects/dna-replication
120 skos:definition Origin firing is the initiation of DNA replication that takes place at specialised start sites, or replication origins, where the DNA first has to be opened up and unwound, before DNA synthesis machinery is loaded to start replication. Not all replication origins are fired at the same time
121 skos:inScheme sg:ontologies/subjects/
122 skos:prefLabel Origin firing
123 sg:ontologies/subjects/origin-selection sgo:sdDataset onto_subjects
124 rdf:type npg:Subject
125 skos:Concept
126 rdfs:label Origin selection
127 skos:broader sg:ontologies/subjects/dna-replication
128 skos:definition Each time the DNA is replicated, only a subset of replication origins are used, and origin usage also changes during development. How the selection of origins is achieved is not clear but may involve chromatin structure and availability of replication initiation proteins
129 skos:inScheme sg:ontologies/subjects/
130 skos:prefLabel Origin selection
131 sg:ontologies/subjects/replisome sgo:sdDataset onto_subjects
132 rdf:type npg:Subject
133 skos:Concept
134 rdfs:label Replisome
135 skos:broader sg:ontologies/subjects/dna-replication
136 skos:definition The replisome is a large protein complex that carries out DNA replication, starting at the replication origin. It contains several enzymatic activities, such as helicase, primase and DNA polymerase and creates a replication fork to duplicate both the leading and lagging strand.
137 skos:inScheme sg:ontologies/subjects/
138 skos:prefLabel Replisome
139 sg:ontologies/subjects/stalled-forks sgo:sdDataset onto_subjects
140 rdf:type npg:Subject
141 skos:Concept
142 rdfs:label Stalled forks
143 skos:broader sg:ontologies/subjects/dna-replication
144 skos:definition Replication fork stalling occurs if the replication proteins, or replisome, encounter problems. Stalled forks activate checkpoint signalling and therefore pause replication.
145 skos:inScheme sg:ontologies/subjects/
146 skos:prefLabel Stalled forks
147 sg:ontologies/subjects/translesion-synthesis sgo:sdDataset onto_subjects
148 rdf:type npg:Subject
149 skos:Concept
150 rdfs:label Translesion synthesis
151 skos:broader sg:ontologies/subjects/dna-damage-and-repair
152 sg:ontologies/subjects/dna-replication
153 skos:definition Translesion synthesis can bypass a replication block caused by various DNA damage. Specialised translesion synthesis DNA polymerases can replicate DNA over such lesions to resume publication but the enzymes are error prone.
154 skos:inScheme sg:ontologies/subjects/
155 skos:prefLabel Translesion synthesis
156 skos:Concept sgo:sdDataset for_codes
157 rdf:type rdfs:Class
158 rdfs:Resource
159 rdfs:subClassOf rdfs:Resource
160 skos:Concept
 




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