DNA damage and repair


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

DNA damage and repair

DESCRIPTION

DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce mutations if not corrected, multiple cellular DNA repair mechanisms exist to remove damaged regions of chromosomes to prevent these potentially deleterious effects.

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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/ontologies/subjects/dna-damage-and-repair'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/ontologies/subjects/dna-damage-and-repair'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/ontologies/subjects/dna-damage-and-repair'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/ontologies/subjects/dna-damage-and-repair'


 

This table displays all metadata directly associated to this object as RDF triples.

209 TRIPLES      10 PREDICATES      33 URIs      16 LITERALS

Subject Predicate Object
1 sg:ontologies/subjects/dna-damage-and-repair sgo:license sg:explorer/license/
2 sgo:sdDataset onto_subjects
3 rdf:type npg:Subject
4 skos:Concept
5 rdfs:label DNA damage and repair
6 skos:altLabel Base Excision Repair
7 Base Excision Repairs
8 DNA Damage
9 DNA Damages
10 DNA Injuries
11 DNA Injury
12 Excision Repair
13 Excision Repairs
14 Genotoxic Stress
15 Genotoxic Stresses
16 Nucleotide Excision Repair
17 Nucleotide Excision Repairs
18 skos:broader sg:ontologies/subjects/molecular-biology
19 skos:definition DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce mutations if not corrected, multiple cellular DNA repair mechanisms exist to remove damaged regions of chromosomes to prevent these potentially deleterious effects.
20 skos:inScheme sg:ontologies/subjects/
21 skos:narrower sg:ontologies/subjects/base-excision-repair
22 sg:ontologies/subjects/dna-adducts
23 sg:ontologies/subjects/dna-damage-checkpoints
24 sg:ontologies/subjects/dna-damage-response
25 sg:ontologies/subjects/dna-mismatch-repair
26 sg:ontologies/subjects/double-strand-dna-breaks
27 sg:ontologies/subjects/homologous-recombination
28 sg:ontologies/subjects/non-homologous-end-joining
29 sg:ontologies/subjects/nucleotide-excision-repair
30 sg:ontologies/subjects/single-strand-dna-breaks
31 sg:ontologies/subjects/translesion-synthesis
32 skos:prefLabel DNA damage and repair
33 sg:ontologies/subjects/ dcterms:description The Nature Subjects Taxonomy is a polyhierarchical categorization of scholarly subject areas which are used for the indexing of content by Springer Nature.
34 dcterms:title Nature Subjects Taxonomy
35 sgo:sdDataset onto_subjects
36 rdf:type skos:ConceptScheme
37 skos:hasTopConcept sg:ontologies/subjects/DEPRECATED
38 sg:ontologies/subjects/biological-sciences
39 sg:ontologies/subjects/business-and-commerce
40 sg:ontologies/subjects/earth-and-environmental-sciences
41 sg:ontologies/subjects/health-sciences
42 sg:ontologies/subjects/humanities
43 sg:ontologies/subjects/physical-sciences
44 sg:ontologies/subjects/scientific-community-and-society
45 sg:ontologies/subjects/social-science
46 sg:ontologies/subjects/base-excision-repair sgo:sdDataset onto_subjects
47 rdf:type npg:Subject
48 skos:Concept
49 rdfs:label Base excision repair
50 skos:altLabel Base Excision Repairs
51 DNA Repair
52 Excision Repair
53 Excision Repairs
54 Nucleotide Excision Repair
55 Nucleotide Excision Repairs
56 skos:broader sg:ontologies/subjects/dna-damage-and-repair
57 skos:definition Base excision repair is a process that removes and replaces damaged or misincorporated bases in one strand of the DNA that may generate mutations if left unrepaired. The damaged base is modified and excised to create a single-stranded DNA break that is repaired to regenerate an intact helix.
58 skos:inScheme sg:ontologies/subjects/
59 skos:prefLabel Base excision repair
60 sg:ontologies/subjects/dna-adducts sgo:sdDataset onto_subjects
61 rdf:type npg:Subject
62 skos:Concept
63 rdfs:label DNA adducts
64 skos:broader sg:ontologies/subjects/dna-damage-and-repair
65 skos:definition DNA adducts are a form of DNA damage caused by covalent attachment of a chemical moiety to DNA. Adducts that are not removed by the cell can cause mutations that may give rise to cancer. They are frequently used as biomarkers for chemical hazard exposure or cancer therapy efficacy.
66 skos:inScheme sg:ontologies/subjects/
67 skos:prefLabel DNA adducts
68 sg:ontologies/subjects/dna-damage-checkpoints sgo:sdDataset onto_subjects
69 rdf:type npg:Subject
70 skos:Concept
71 rdfs:label DNA damage checkpoints
72 skos:broader sg:ontologies/subjects/dna-damage-and-repair
73 skos:definition A DNA damage checkpoint is a pause in the cell cycle that is induced in response to DNA damage to ensure that the damage is repaired before cell division resumes. Proteins that accumulate at the damage site typically activate the checkpoint and halt cell growth at the G1/S or G2/M boundaries.
74 skos:inScheme sg:ontologies/subjects/
75 skos:prefLabel DNA damage checkpoints
76 sg:ontologies/subjects/dna-damage-response sgo:sdDataset onto_subjects
77 rdf:type npg:Subject
78 skos:Concept
79 rdfs:label DNA damage response
80 skos:broader sg:ontologies/subjects/dna-damage-and-repair
81 skos:definition The DNA damage response is a network of cellular pathways that sense, signal and repair DNA lesions. Surveillance proteins that monitor DNA integrity can activate cell cycle checkpoints and DNA repair pathways in response to DNA damage, to prevent the generation of potentially deleterious mutations.
82 skos:inScheme sg:ontologies/subjects/
83 skos:prefLabel DNA damage response
84 sg:ontologies/subjects/dna-mismatch-repair sgo:sdDataset onto_subjects
85 rdf:type npg:Subject
86 skos:Concept
87 rdfs:label DNA mismatch repair
88 skos:altLabel Mismatch Repair
89 skos:broader sg:ontologies/subjects/dna-damage-and-repair
90 skos:definition DNA mismatch repair is a process that removes and replaces nucleotides that are erroneously inserted during DNA replication. Non-complementary bases on the newly synthesized DNA strand are recognized and excised, often with surrounding bases, to generate a gap that is repaired by copying the undamaged DNA strand.
91 skos:inScheme sg:ontologies/subjects/
92 skos:prefLabel DNA mismatch repair
93 sg:ontologies/subjects/double-strand-dna-breaks sgo:sdDataset onto_subjects
94 rdf:type npg:Subject
95 skos:Concept
96 rdfs:label Double-strand DNA breaks
97 skos:altLabel Double Strand DNA Breaks
98 Double Stranded DNA Break
99 Double Stranded DNA Breaks
100 Double-Strand DNA Break
101 Double-Stranded DNA Break
102 Double-Stranded DNA Breaks
103 skos:broader sg:ontologies/subjects/dna-damage-and-repair
104 skos:definition A double-strand DNA break (DSB) occurs or arises when both strands of the DNA duplex are severed, often as the result of ionizing radiation. They are particularly deleterious as the DNA ends can promote potentially lethal chromosomal rearrangements, and can be repaired by homologous recombination (HR) or non-homologous-end joining (NHEJ).
105 skos:inScheme sg:ontologies/subjects/
106 skos:prefLabel Double-strand DNA breaks
107 sg:ontologies/subjects/homologous-recombination sgo:sdDataset onto_subjects
108 rdf:type npg:Subject
109 skos:Concept
110 rdfs:label Homologous recombination
111 skos:altLabel Homologous Recombinations
112 skos:broader sg:ontologies/subjects/dna-damage-and-repair
113 skos:definition Homologous recombination is the exchange of DNA strands of similar or identical nucleotide sequence. It can be used to direct error-free repair of double-strand DNA breaks and generates sequence variation in gametes during meiosis.
114 skos:inScheme sg:ontologies/subjects/
115 skos:prefLabel Homologous recombination
116 sg:ontologies/subjects/molecular-biology sgo:sdDataset onto_subjects
117 rdf:type npg:Subject
118 skos:Concept
119 rdfs:label Molecular biology
120 skos:altLabel Biochemical Genetic
121 Biochemical Genetics
122 Molecular Genetic
123 Molecular Genetics
124 skos:broader sg:ontologies/subjects/biological-sciences
125 skos:definition Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules – such as nucleic acids and proteins – that carry out the biological processes essential for the cell’s functions and maintenance.
126 skos:inScheme sg:ontologies/subjects/
127 skos:narrower sg:ontologies/subjects/cell-division
128 sg:ontologies/subjects/chromatin
129 sg:ontologies/subjects/chromosomes
130 sg:ontologies/subjects/crispr-cas-systems
131 sg:ontologies/subjects/dna-damage-and-repair
132 sg:ontologies/subjects/dna-metabolism
133 sg:ontologies/subjects/dna-recombination
134 sg:ontologies/subjects/dna-replication
135 sg:ontologies/subjects/epigenetics
136 sg:ontologies/subjects/non-coding-rnas
137 sg:ontologies/subjects/nuclear-organization
138 sg:ontologies/subjects/post-translational-modifications
139 sg:ontologies/subjects/protein-folding
140 sg:ontologies/subjects/proteolysis
141 sg:ontologies/subjects/proteomics
142 sg:ontologies/subjects/riboswitches
143 sg:ontologies/subjects/ribozymes
144 sg:ontologies/subjects/rna-metabolism
145 sg:ontologies/subjects/rnai
146 sg:ontologies/subjects/single-molecule-biophysics
147 sg:ontologies/subjects/transcription
148 sg:ontologies/subjects/transcriptomics
149 sg:ontologies/subjects/translation
150 sg:ontologies/subjects/transposition
151 skos:prefLabel Molecular biology
152 sg:ontologies/subjects/non-homologous-end-joining sgo:sdDataset onto_subjects
153 rdf:type npg:Subject
154 skos:Concept
155 rdfs:label Non-homologous-end joining
156 skos:altLabel End-Joining DNA Repair
157 MMEJ DNA Repair
158 Microhomology-Mediated End Joining Repair
159 NHEJ DNA Repair
160 Non-Homologous DNA End-Joining
161 Nonhomologous DNA End-Joining
162 skos:broader sg:ontologies/subjects/dna-damage-and-repair
163 skos:definition Non-homologous-end joining is the repair of double-strand DNA breaks by direct ligation of the broken ends. No homology is required to promote the end-joining reaction, but it is more error prone than recombination-based repair.
164 skos:inScheme sg:ontologies/subjects/
165 skos:prefLabel Non-homologous-end joining
166 sg:ontologies/subjects/nucleotide-excision-repair sgo:sdDataset onto_subjects
167 rdf:type npg:Subject
168 skos:Concept
169 rdfs:label Nucleotide excision repair
170 skos:altLabel Base Excision Repair
171 Base Excision Repairs
172 DNA Repair
173 Excision Repair
174 Excision Repairs
175 Nucleotide Excision Repairs
176 skos:broader sg:ontologies/subjects/dna-damage-and-repair
177 skos:definition Nucleotide excision repair is a process that repairs damage to one strand of the DNA, particularly from UV irradiation, which distorts the DNA helix. The DNA flanking the damage site is cleaved to generate a single-stranded gap that is repaired by copying the undamaged strand to restore an intact helix.
178 skos:inScheme sg:ontologies/subjects/
179 skos:prefLabel Nucleotide excision repair
180 sg:ontologies/subjects/single-strand-dna-breaks sgo:sdDataset onto_subjects
181 rdf:type npg:Subject
182 skos:Concept
183 rdfs:label Single-strand DNA breaks
184 skos:altLabel DNA Nick
185 DNA Nicks
186 Single Strand DNA Breaks
187 Single Stranded DNA Break
188 Single Stranded DNA Breaks
189 Single-Strand DNA Break
190 Single-Stranded DNA Break
191 Single-Stranded DNA Breaks
192 skos:broader sg:ontologies/subjects/dna-damage-and-repair
193 skos:definition A single-strand DNA break arises when only one strand of the DNA duplex is severed. They are typically corrected by excision repair pathways.
194 skos:inScheme sg:ontologies/subjects/
195 skos:prefLabel Single-strand DNA breaks
196 sg:ontologies/subjects/translesion-synthesis sgo:sdDataset onto_subjects
197 rdf:type npg:Subject
198 skos:Concept
199 rdfs:label Translesion synthesis
200 skos:broader sg:ontologies/subjects/dna-damage-and-repair
201 sg:ontologies/subjects/dna-replication
202 skos:definition Translesion synthesis can bypass a replication block caused by various DNA damage. Specialised translesion synthesis DNA polymerases can replicate DNA over such lesions to resume publication but the enzymes are error prone.
203 skos:inScheme sg:ontologies/subjects/
204 skos:prefLabel Translesion synthesis
205 skos:Concept sgo:sdDataset for_codes
206 rdf:type rdfs:Class
207 rdfs:Resource
208 rdfs:subClassOf rdfs:Resource
209 skos:Concept
 




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