Cytokines


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Cytokines

DESCRIPTION

Cytokines are proteins, peptides or glycoproteins secreted by lymphocytes and monocytes that regulate immune responses, haematopoiesis and lymphocyte development. Cytokines include interleukins, chemokines and other signalling molecules. Each cytokine acts through its own receptor on target cells, and these receptors include members of the immunoglobulin (Ig) superfamily and tumour necrosis factor (TNF).

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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/ontologies/subjects/cytokines'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/ontologies/subjects/cytokines'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/ontologies/subjects/cytokines'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/ontologies/subjects/cytokines'


 

This table displays all metadata directly associated to this object as RDF triples.

291 TRIPLES      9 PREDICATES      24 URIs      4 LITERALS

Subject Predicate Object
1 sg:ontologies/subjects/cytokines sgo:license sg:explorer/license/
2 sgo:sdDataset onto_subjects
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8 skos:definition Cytokines are proteins, peptides or glycoproteins secreted by lymphocytes and monocytes that regulate immune responses, haematopoiesis and lymphocyte development. Cytokines include interleukins, chemokines and other signalling molecules. Each cytokine acts through its own receptor on target cells, and these receptors include members of the immunoglobulin (Ig) superfamily and tumour necrosis factor (TNF).
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42 Glucosephosphate Isomerase
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49 skos:definition Autocrine motility factor (AMF) is a substance secreted by a cell that acts via surface receptors on the same cell to regulate cell motility pathways by signalling through the GTPase Rho to the actin cytoskeleton, and through PI3 kinase. When derived from tumours, AMF can enhance cell migration, leading to tumour metastasis.
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117 skos:definition Haematopoietic cell growth factors are proteins that regulate growth and differentiation of red and white blood cells – haematopoietic cells. These include the cytokine SCF (stem cell factor), involved in proliferation and self-renewal of haematopoietic cells, as well as erythropoietin and colony-stimulating factors (CSFs), which stimulate the production of erythrocyte, granulocyte and macrophage blood cell lineages.
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186 skos:definition Interferons are glycoprotein cytokines secreted by host lymphocytes in response to pathogens. Interferons activate or upregulate immune cells by interacting with receptors that activate signal transducer and activator of transcription (STAT) signalling complexes. This ultimately leads to clearance of the pathogen or clearance of tumour cells from the organism.
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201 rdfs:label Leukaemia inhibitory factor
202 skos:altLabel AM424
203 AMRAD Brand of Recombinant Human Leukemia Inhibitory Factor
204 Cholinergic Differentiation Factor
205 D Factor
206 D Factor (Leukemia Inhibitory Factor)
207 Differentiation Stimulating Factor
208 Differentiation-Stimulating Factor
209 Emfilermin
210 LIF
211 Leukemia inhibitory factor
212 Myeloid Differentiation Stimulating Factor
213 Myeloid Differentiation-Stimulating Factor
214 skos:broader sg:ontologies/subjects/cytokines
215 skos:definition Leukaemia inhibitory factor (LIF) is a cytokine of the interleukin-6 family, which is both pro-inflammatory and anti-inflammatory. LIF, acting through its receptor LIFR-α, induces terminal differentiation, and therefore cessation of growth, of myeloid leukaemia cells. LIF also acts on other target cells and tissues, including bone, neurons, heart and embryos, to promote growth and differentiation.
216 skos:inScheme sg:ontologies/subjects/
217 skos:prefLabel Leukaemia inhibitory factor
218 sg:ontologies/subjects/lymphokines sgo:sdDataset onto_subjects
219 rdf:type npg:Subject
220 skos:Concept
221 rdfs:label Lymphokines
222 skos:altLabel Lymphocyte Mediators
223 skos:broader sg:ontologies/subjects/cytokines
224 skos:definition Lymphokines are cytokines produced by T cells (lymphocytes) of the immune system. Lymphokines act to attract additional immune cells to mount an immune response, for instance in stimulating B cells to generate antibodies against the invading pathogen.
225 skos:inScheme sg:ontologies/subjects/
226 skos:prefLabel Lymphokines
227 sg:ontologies/subjects/monokines sgo:sdDataset onto_subjects
228 rdf:type npg:Subject
229 skos:Concept
230 rdfs:label Monokines
231 skos:broader sg:ontologies/subjects/cytokines
232 skos:definition Monokines are cytokines produced mainly by monocytes and macrophages for function in the immune system. Monokines can function as chemoattractants for guiding neutrophil migration.
233 skos:inScheme sg:ontologies/subjects/
234 skos:prefLabel Monokines
235 sg:ontologies/subjects/oncostatin-m sgo:sdDataset onto_subjects
236 rdf:type npg:Subject
237 skos:Concept
238 rdfs:label Oncostatin M
239 skos:broader sg:ontologies/subjects/cytokines
240 skos:definition Oncostatin M is a secreted cytokine, and is related to leukaemia inhibitory factor. Oncostatin M functions in differentiation and development of various cell lineages, cell proliferation, and haematopoiesis. The transmembrane receptor for Oncostatin M on responding cells is a heterodimer between the glycoprotein gp130 and either CD118/LIFR or OSMR.
241 skos:inScheme sg:ontologies/subjects/
242 skos:prefLabel Oncostatin M
243 sg:ontologies/subjects/osteopontin sgo:sdDataset onto_subjects
244 rdf:type npg:Subject
245 skos:Concept
246 rdfs:label Osteopontin
247 skos:altLabel BNSP
248 Bone Sialoprotein 1
249 Bone Sialoprotein I
250 ETA-1 protein
251 Ric protein
252 Rickettsia resistance protein
253 SPP1
254 Secreted Phosphoprotein 1
255 Secreted phosphoprotein 1
256 Sialoprotein 1
257 Uropontin
258 early T-lymphocyte activation protein
259 skos:broader sg:ontologies/subjects/cytokines
260 skos:definition Osteopontin is an acidic phosphoprotein produced by osteoblasts and other cell types. Osteopontin is an extracellular protein that has a cell-adhesion sequence (RGD) that mediates its interaction with integrins and extracellular matrix components. It has functions in biomineralization of bone, chemotaxis, apoptosis and cell activation in immunity.
261 skos:inScheme sg:ontologies/subjects/
262 skos:prefLabel Osteopontin
263 sg:ontologies/subjects/transforming-growth-factor-beta sgo:sdDataset onto_subjects
264 rdf:type npg:Subject
265 skos:Concept
266 rdfs:label Transforming growth factor beta
267 skos:altLabel Bone Derived Transforming Growth Factor
268 Bone-Derived Transforming Growth Factor
269 Milk Growth Factor
270 Platelet Transforming Growth Factor
271 TGF-beta
272 TGFbeta
273 skos:broader sg:ontologies/subjects/cytokines
274 skos:definition Transforming growth factor beta (TGFβ) is a cytokine that is secreted by various cell types, including macrophages, and functions in cell growth, cell differentiation, apoptosis and cellular homeostasis by binding to its receptor, the TGFβ type II receptor. Multiple signalling pathways lie downstream of the receptor, including the SMAD transcription factors and cell-cycle proteins.
275 skos:inScheme sg:ontologies/subjects/
276 skos:prefLabel Transforming growth factor beta
277 sg:ontologies/subjects/tumour-necrosis-factors sgo:sdDataset onto_subjects
278 rdf:type npg:Subject
279 skos:Concept
280 rdfs:label Tumour-necrosis factors
281 skos:altLabel TNF Receptor Ligands
282 Tumor Necrosis Factor Superfamily Ligands
283 skos:broader sg:ontologies/subjects/cytokines
284 skos:definition Tumour-necrosis factors are cytokines that are secreted by immune cell such as monocytes and lymphocytes. Tumour-necrosis factors can cause cell death or T cell activation and proliferation by binding to their receptors as a homotrimer or heterotrimer.
285 skos:inScheme sg:ontologies/subjects/
286 skos:prefLabel Tumour-necrosis factors
287 skos:Concept sgo:sdDataset for_codes
288 rdf:type rdfs:Class
289 rdfs:Resource
290 rdfs:subClassOf rdfs:Resource
291 skos:Concept
 




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