Chromatin


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Chromatin

DESCRIPTION

Chromatin is a flexibly joined chain of nucleosomes that exists inside the nucleus of eukaryotic cells and has been described as a 'bead on a string'. Chromatin organization strengthens DNA for mechanically stressful processes like mitosis, helps protect DNA from damage and is important in the control of gene expression and DNA replication.

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This table displays all metadata directly associated to this object as RDF triples.

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5 rdfs:label Chromatin
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10 skos:inScheme sg:ontologies/subjects/
11 skos:narrower sg:ontologies/subjects/chromatin-remodelling
12 sg:ontologies/subjects/chromatin-structure
13 sg:ontologies/subjects/histone-post-translational-modifications
14 sg:ontologies/subjects/histone-variants
15 sg:ontologies/subjects/nucleosomes
16 skos:prefLabel Chromatin
17 sg:ontologies/subjects/ dcterms:description The Nature Subjects Taxonomy is a polyhierarchical categorization of scholarly subject areas which are used for the indexing of content by Springer Nature.
18 dcterms:title Nature Subjects Taxonomy
19 sgo:sdDataset onto_subjects
20 rdf:type skos:ConceptScheme
21 skos:hasTopConcept sg:ontologies/subjects/DEPRECATED
22 sg:ontologies/subjects/biological-sciences
23 sg:ontologies/subjects/business-and-commerce
24 sg:ontologies/subjects/earth-and-environmental-sciences
25 sg:ontologies/subjects/health-sciences
26 sg:ontologies/subjects/humanities
27 sg:ontologies/subjects/physical-sciences
28 sg:ontologies/subjects/scientific-community-and-society
29 sg:ontologies/subjects/social-science
30 sg:ontologies/subjects/chromatin-remodelling sgo:sdDataset onto_subjects
31 rdf:type npg:Subject
32 skos:Concept
33 rdfs:label Chromatin remodelling
34 skos:altLabel Chromatin Assembly
35 Chromatin Assembly and Disassembly
36 Chromatin Disassemblies
37 Chromatin Disassembly
38 Chromatin Modeling
39 Chromatin Remodeling
40 skos:broader sg:ontologies/subjects/chromatin
41 skos:definition Chromatin remodelling is the process by which the DNA wrapped within nucleosomes becomes accessible to regulatory elements, such as transcription factors and the replication machinery. Chromatin remodelling can result from covalent modification of histones by histone acetyltransferases, histone deacetylases, histone methyltransferases or kinases, and by ATP-dependent protein complexes that physically remodel, move or remove nucleosomes.
42 skos:inScheme sg:ontologies/subjects/
43 skos:prefLabel Chromatin remodelling
44 sg:ontologies/subjects/chromatin-structure sgo:sdDataset onto_subjects
45 rdf:type npg:Subject
46 skos:Concept
47 rdfs:label Chromatin structure
48 skos:broader sg:ontologies/subjects/chromatin
49 skos:definition Chromatin structure describes the physical structure of chromatin within the eukaryotic nucleus and how structure affects chromatin processes such as transcription. The repeating unit of chromatin, the nucleosome, consists of approximately 147 base pairs of DNA wrapped around eight histone protein cores. Linker DNA, upwards of 80 base pairs long, connects two histones between each nucleosome core unit.
50 skos:inScheme sg:ontologies/subjects/
51 skos:prefLabel Chromatin structure
52 sg:ontologies/subjects/histone-post-translational-modifications sgo:sdDataset onto_subjects
53 rdf:type npg:Subject
54 skos:Concept
55 rdfs:label Histone post-translational modifications
56 skos:broader sg:ontologies/subjects/chromatin
57 skos:definition Histone post-translational modifications are covalent modifications of histones by phosphorylation on serine or threonine residues, methylation on lysine or arginine, acetylation and deacetylation of lysines, ubiquitylation of lysines and sumoylation of lysines. Histone modifications are proposed to affect chromosome structure and function, for instance during transcription and chromatin remodelling processes.
58 skos:inScheme sg:ontologies/subjects/
59 skos:prefLabel Histone post-translational modifications
60 sg:ontologies/subjects/histone-variants sgo:sdDataset onto_subjects
61 rdf:type npg:Subject
62 skos:Concept
63 rdfs:label Histone variants
64 skos:broader sg:ontologies/subjects/chromatin
65 skos:definition Histone variants are non-canonical (non-allelic) variants of histones – representing one or a few amino acid differences – that are expressed at very low levels compared with their conventional counterparts. Histone variants have specific expression, localization and species-distribution patterns, and confer novel structural and functional properties on the nucleosome, affecting chromatin remodelling and histone post-translational modifications.
66 skos:inScheme sg:ontologies/subjects/
67 skos:prefLabel Histone variants
68 sg:ontologies/subjects/molecular-biology sgo:sdDataset onto_subjects
69 rdf:type npg:Subject
70 skos:Concept
71 rdfs:label Molecular biology
72 skos:altLabel Biochemical Genetic
73 Biochemical Genetics
74 Molecular Genetic
75 Molecular Genetics
76 skos:broader sg:ontologies/subjects/biological-sciences
77 skos:definition Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules – such as nucleic acids and proteins – that carry out the biological processes essential for the cell’s functions and maintenance.
78 skos:inScheme sg:ontologies/subjects/
79 skos:narrower sg:ontologies/subjects/cell-division
80 sg:ontologies/subjects/chromatin
81 sg:ontologies/subjects/chromosomes
82 sg:ontologies/subjects/crispr-cas-systems
83 sg:ontologies/subjects/dna-damage-and-repair
84 sg:ontologies/subjects/dna-metabolism
85 sg:ontologies/subjects/dna-recombination
86 sg:ontologies/subjects/dna-replication
87 sg:ontologies/subjects/epigenetics
88 sg:ontologies/subjects/non-coding-rnas
89 sg:ontologies/subjects/nuclear-organization
90 sg:ontologies/subjects/post-translational-modifications
91 sg:ontologies/subjects/protein-folding
92 sg:ontologies/subjects/proteolysis
93 sg:ontologies/subjects/proteomics
94 sg:ontologies/subjects/riboswitches
95 sg:ontologies/subjects/ribozymes
96 sg:ontologies/subjects/rna-metabolism
97 sg:ontologies/subjects/rnai
98 sg:ontologies/subjects/single-molecule-biophysics
99 sg:ontologies/subjects/transcription
100 sg:ontologies/subjects/transcriptomics
101 sg:ontologies/subjects/translation
102 sg:ontologies/subjects/transposition
103 skos:prefLabel Molecular biology
104 sg:ontologies/subjects/nucleosomes sgo:sdDataset onto_subjects
105 rdf:type npg:Subject
106 skos:Concept
107 rdfs:label Nucleosomes
108 skos:altLabel Dinucleosome
109 Dinucleosomes
110 Nucleosome
111 Polynucleosome
112 Polynucleosomes
113 skos:broader sg:ontologies/subjects/chromatin
114 skos:definition Nucleosomes are the repeating unit of chromatin, and consist of approximately 147 base pairs of DNA wrapped around eight histone protein cores to allow chromosomal DNA to be packaged into a small volume. Nucleosomes are the 'beads' in the 'bead-on-a-string' depiction of chromatin.
115 skos:inScheme sg:ontologies/subjects/
116 skos:prefLabel Nucleosomes
117 sg:ontologies/subjects/proteins sgo:sdDataset onto_subjects
118 rdf:type npg:Subject
119 skos:Concept
120 rdfs:label Proteins
121 skos:altLabel Gene Proteins
122 Protein
123 Protein Gene Products
124 skos:broader sg:ontologies/subjects/biochemistry
125 sg:ontologies/subjects/chemical-biology
126 skos:definition Proteins are biopolymers of amino acids (polypeptides), joined by peptide bonds, that are generated by ribosomes. The amino acid sequence, encoded by its gene, determines a protein’s structure and function. Newly synthesized proteins can be modified by post-translational modification, altering its protein folding, stability and activity. Proteins often associate into protein–protein interaction networks for function.
127 skos:inScheme sg:ontologies/subjects/
128 skos:narrower sg:ontologies/subjects/acetyltransferases
129 sg:ontologies/subjects/blood-proteins
130 sg:ontologies/subjects/carrier-proteins
131 sg:ontologies/subjects/cell-cycle-proteins
132 sg:ontologies/subjects/cerebrospinal-fluid-proteins
133 sg:ontologies/subjects/chaperones
134 sg:ontologies/subjects/chromatin
135 sg:ontologies/subjects/circadian-rhythm-signalling-peptides-and-proteins
136 sg:ontologies/subjects/colipases
137 sg:ontologies/subjects/complement
138 sg:ontologies/subjects/contractile-proteins
139 sg:ontologies/subjects/cytoskeletal-proteins
140 sg:ontologies/subjects/dna-binding-proteins
141 sg:ontologies/subjects/g-protein-coupled-receptors
142 sg:ontologies/subjects/glycoproteins
143 sg:ontologies/subjects/gtp-binding-protein-regulators
144 sg:ontologies/subjects/integrins
145 sg:ontologies/subjects/intracellular-signalling-peptides-and-proteins
146 sg:ontologies/subjects/lectins
147 sg:ontologies/subjects/lipoproteins
148 sg:ontologies/subjects/membrane-proteins
149 sg:ontologies/subjects/metalloproteins
150 sg:ontologies/subjects/methylases
151 sg:ontologies/subjects/mitochondrial-proteins
152 sg:ontologies/subjects/nuclear-receptors
153 sg:ontologies/subjects/nucleases
154 sg:ontologies/subjects/nucleoproteins
155 sg:ontologies/subjects/nucleotide-binding-proteins
156 sg:ontologies/subjects/oncogene-proteins
157 sg:ontologies/subjects/phosphoproteins
158 sg:ontologies/subjects/phosphorylases
159 sg:ontologies/subjects/proteome
160 sg:ontologies/subjects/ribosomal-proteins
161 sg:ontologies/subjects/rna-binding-proteins
162 sg:ontologies/subjects/scleroproteins
163 sg:ontologies/subjects/selenium-binding-proteins
164 sg:ontologies/subjects/sumoylated-proteins
165 sg:ontologies/subjects/thioredoxins
166 sg:ontologies/subjects/transcription-factors
167 sg:ontologies/subjects/tumour-suppressor-proteins
168 sg:ontologies/subjects/ubiquitins
169 sg:ontologies/subjects/ubiquitylated-proteins
170 sg:ontologies/subjects/viral-proteins
171 skos:prefLabel Proteins
172 skos:Concept sgo:sdDataset for_codes
173 rdf:type rdfs:Class
174 rdfs:Resource
175 rdfs:subClassOf rdfs:Resource
176 skos:Concept
 




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