Cancer genetics


Ontology type: npg:Subject  | skos:Concept     


Concept Info

NAME

Cancer genetics

DESCRIPTION

Cancer genetics is the study in humans and other animals of heritable gene variants that cause or confer altered risk of tumour or hematological malignancy. Individual cancer risk varies and is influenced by familial and sporadic oncogene or tumour suppressor gene mutations as well as rare and common constitutional variants present in the population.

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14 skos:inScheme sg:ontologies/subjects/
15 skos:narrower sg:ontologies/subjects/cancer-epigenetics
16 skos:prefLabel Cancer genetics
17 sg:ontologies/subjects/ dcterms:description The Nature Subjects Taxonomy is a polyhierarchical categorization of scholarly subject areas which are used for the indexing of content by Springer Nature.
18 dcterms:title Nature Subjects Taxonomy
19 sgo:sdDataset onto_subjects
20 rdf:type skos:ConceptScheme
21 skos:hasTopConcept sg:ontologies/subjects/DEPRECATED
22 sg:ontologies/subjects/biological-sciences
23 sg:ontologies/subjects/business-and-commerce
24 sg:ontologies/subjects/earth-and-environmental-sciences
25 sg:ontologies/subjects/health-sciences
26 sg:ontologies/subjects/humanities
27 sg:ontologies/subjects/physical-sciences
28 sg:ontologies/subjects/scientific-community-and-society
29 sg:ontologies/subjects/social-science
30 sg:ontologies/subjects/cancer sgo:sdDataset onto_subjects
31 rdf:type npg:Subject
32 skos:Concept
33 rdfs:label Cancer
34 skos:altLabel Benign Neoplasm
35 Benign Neoplasms
36 Benign Tumor
37 Benign Tumors
38 Benign Tumour
39 Benign Tumours
40 Cancers
41 Neoplasia
42 Neoplasm
43 Neoplasms
44 Tumor
45 Tumors
46 Tumour
47 Tumours
48 skos:broader sg:ontologies/subjects/biological-sciences
49 sg:ontologies/subjects/diseases
50 sg:ontologies/subjects/oncology
51 skos:definition Cancer is a complex disease in which cells in a specific tissue are no longer fully responsive to the signals within the tissue that regulate cellular differentiation, survival, proliferation and death. As a result, these cells accumulate within the tissue, causing local damage and inflammation. There are over 200 different types of cancer.
52 skos:inScheme sg:ontologies/subjects/
53 skos:narrower sg:ontologies/subjects/bone-cancer
54 sg:ontologies/subjects/breast-cancer
55 sg:ontologies/subjects/cancer-epidemiology
56 sg:ontologies/subjects/cancer-genetics
57 sg:ontologies/subjects/cancer-genomics
58 sg:ontologies/subjects/cancer-imaging
59 sg:ontologies/subjects/cancer-metabolism
60 sg:ontologies/subjects/cancer-microenvironment
61 sg:ontologies/subjects/cancer-models
62 sg:ontologies/subjects/cancer-of-unknown-primary
63 sg:ontologies/subjects/cancer-prevention
64 sg:ontologies/subjects/cancer-screening
65 sg:ontologies/subjects/cancer-stem-cells
66 sg:ontologies/subjects/cancer-therapy
67 sg:ontologies/subjects/cns-cancer
68 sg:ontologies/subjects/cysts
69 sg:ontologies/subjects/embryonal-neoplasms
70 sg:ontologies/subjects/endocrine-cancer
71 sg:ontologies/subjects/eye-cancer
72 sg:ontologies/subjects/gastrointestinal-cancer
73 sg:ontologies/subjects/germ-cell-tumours
74 sg:ontologies/subjects/gynaecological-cancer
75 sg:ontologies/subjects/haematological-cancer
76 sg:ontologies/subjects/hamartoma
77 sg:ontologies/subjects/head-and-neck-cancer
78 sg:ontologies/subjects/lung-cancer
79 sg:ontologies/subjects/mesothelioma
80 sg:ontologies/subjects/metastases
81 sg:ontologies/subjects/oncogenes
82 sg:ontologies/subjects/oral-cancer
83 sg:ontologies/subjects/paediatric-cancer
84 sg:ontologies/subjects/sarcoma
85 sg:ontologies/subjects/skin-cancer
86 sg:ontologies/subjects/testicular-cancer
87 sg:ontologies/subjects/tumour-angiogenesis
88 sg:ontologies/subjects/tumour-biomarkers
89 sg:ontologies/subjects/tumour-heterogeneity
90 sg:ontologies/subjects/tumour-immunology
91 sg:ontologies/subjects/tumour-suppressor-proteins
92 sg:ontologies/subjects/tumour-virus-infections
93 sg:ontologies/subjects/urological-cancer
94 skos:prefLabel Cancer
95 sg:ontologies/subjects/cancer-epigenetics sgo:sdDataset onto_subjects
96 rdf:type npg:Subject
97 skos:Concept
98 rdfs:label Cancer epigenetics
99 skos:broader sg:ontologies/subjects/cancer-genetics
100 sg:ontologies/subjects/clinical-epigenetics
101 skos:definition Cancer epigenetics is the study of somatically heritable changes to molecular processes that influence the flow of information between the DNA of cancer cells and their gene expression patterns. This includes comparative (tumour cell versus normal cell) investigation of nuclear organization, DNA methylation, histone modification and the consequences of genetic mutations in genes encoding epigenetic regulators.
102 skos:inScheme sg:ontologies/subjects/
103 skos:prefLabel Cancer epigenetics
104 sg:ontologies/subjects/clinical-genetics sgo:sdDataset onto_subjects
105 rdf:type npg:Subject
106 skos:Concept
107 rdfs:label Clinical genetics
108 skos:broader sg:ontologies/subjects/genetics
109 sg:ontologies/subjects/pathogenesis
110 skos:definition Clinical genetics involves the study, counselling and treatment of individuals and families with heritable disorders and disease predisposition. Diagnostic tools include standard ontologies for describing dysmorphology and traits, pedigree analysis, disease locus mapping by linkage or homozygosity, karyotyping, genome sequencing and genotyping.
111 skos:inScheme sg:ontologies/subjects/
112 skos:narrower sg:ontologies/subjects/cancer-genetics
113 sg:ontologies/subjects/chromosome-abnormality
114 sg:ontologies/subjects/clinical-epigenetics
115 sg:ontologies/subjects/disease-genetics
116 sg:ontologies/subjects/gene-therapy
117 sg:ontologies/subjects/genetic-testing
118 skos:prefLabel Clinical genetics
119 sg:ontologies/subjects/disease-genetics sgo:sdDataset onto_subjects
120 rdf:type npg:Subject
121 skos:Concept
122 rdfs:label Disease genetics
123 skos:broader sg:ontologies/subjects/clinical-genetics
124 skos:definition Disease genetics, of human, animal and plant diseases, investigates the consequences of pathogenic (host) genetic variants as the major causes of heritable disorders (monogenic diseases) as well as the consequences of genome variation in the population to the variable predisposition of the individual to complex diseases with infectious or environmental causes.
125 skos:inScheme sg:ontologies/subjects/
126 skos:narrower sg:ontologies/subjects/cancer-genetics
127 skos:prefLabel Disease genetics
128 sg:ontologies/subjects/genetics sgo:sdDataset onto_subjects
129 rdf:type npg:Subject
130 skos:Concept
131 rdfs:label Genetics
132 skos:broader sg:ontologies/subjects/biological-sciences
133 skos:definition Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including the molecular structure and function of genes, gene behaviour in the context of a cell or organism (e.g. dominance and epigenetics), gene distribution, and variation and change in populations.
134 skos:inScheme sg:ontologies/subjects/
135 skos:narrower sg:ontologies/subjects/agricultural-genetics
136 sg:ontologies/subjects/animal-breeding
137 sg:ontologies/subjects/behavioural-genetics
138 sg:ontologies/subjects/cancer-genetics
139 sg:ontologies/subjects/cancer-genomics
140 sg:ontologies/subjects/clinical-genetics
141 sg:ontologies/subjects/consanguinity
142 sg:ontologies/subjects/crispr-cas-systems
143 sg:ontologies/subjects/cytogenetics
144 sg:ontologies/subjects/development
145 sg:ontologies/subjects/epigenetics
146 sg:ontologies/subjects/epigenomics
147 sg:ontologies/subjects/eukaryote
148 sg:ontologies/subjects/evolutionary-biology
149 sg:ontologies/subjects/functional-genomics
150 sg:ontologies/subjects/gene-expression
151 sg:ontologies/subjects/gene-regulation
152 sg:ontologies/subjects/genetic-association-study
153 sg:ontologies/subjects/genetic-hybridization
154 sg:ontologies/subjects/genetic-interaction
155 sg:ontologies/subjects/genetic-linkage-study
156 sg:ontologies/subjects/genetic-markers
157 sg:ontologies/subjects/genome
158 sg:ontologies/subjects/genomic-instability
159 sg:ontologies/subjects/genomics
160 sg:ontologies/subjects/genotype
161 sg:ontologies/subjects/haplotypes
162 sg:ontologies/subjects/heritable-quantitative-trait
163 sg:ontologies/subjects/immunogenetics
164 sg:ontologies/subjects/inbreeding
165 sg:ontologies/subjects/medical-genetics
166 sg:ontologies/subjects/microbial-genetics
167 sg:ontologies/subjects/mutation
168 sg:ontologies/subjects/neurodevelopmental-disorders
169 sg:ontologies/subjects/plant-breeding
170 sg:ontologies/subjects/plant-genetics
171 sg:ontologies/subjects/polyploidy
172 sg:ontologies/subjects/population-genetics
173 sg:ontologies/subjects/prokaryote
174 sg:ontologies/subjects/quantitative-trait
175 sg:ontologies/subjects/rna-splicing
176 sg:ontologies/subjects/rnai
177 sg:ontologies/subjects/sequencing
178 skos:prefLabel Genetics
179 skos:Concept sgo:sdDataset for_codes
180 rdf:type rdfs:Class
181 rdfs:Resource
182 rdfs:subClassOf rdfs:Resource
183 skos:Concept
 




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