Genomic characterisation of abdominal aortic aneurysm growth View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

-

FUNDING AMOUNT

587498.0 GBP

ABSTRACT

In the UK, men are offered screening for abdominal aortic aneurysm (AAA). Most AAAs detected are small but inevitably grow over time so are kept under surveillance with regular ultrasound scans. Over 16,000 men are currently in surveillance. Most will spend at least 3 years in such programmes. Whilst they have regular contact with health services, there are no known strategies to prevent AAA growth. Our BHF funded cohort of 5,000 men with small AAAs will be genotyped to determine if genetic risk loci associated with the presence of AAA are also associated with accelerated AAA growth, and to identify new loci associated with AAA growth. In a smaller deeply phenotyped cohort, we will use a multi-platform approach to identify biological factors associated with AAA growth rates. Biological validation of the findings from the genomic and deep-phenotyping studies will be achieved through integration and bioinformatic analysis of the combined datasets. More... »

URL

https://europepmc.org/grantfinder/grantdetails?query=gid%3A"RG/18/10/33842"

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