Quantitative study of tissue perfusion and diffusion during the evolution of atherosclerotic plaque by magnetic resonance


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2016-2016

FUNDING AMOUNT

100000.0 CNY

ABSTRACT

Atherosclerosis is the main cause of coronary heart disease and ischemic stroke, and plaque rupture and acute thrombus formation is the result of the consequent acute ischemic events (acute myocardial infarction, sudden cardiac death and ischemic stroke) the main mechanism.Some Researches shown that, in atherosclerotic plaque neovascularization is the main reason leading to intraplaque hemorrhage, thrombosis. Therefore, understanding the machenisime of plaque neovascularization will help us on the theraphy of plaque . At present, most studies using high resolution MRI imaging technology especially dynamic enhancement (DCE) to evaluate neovascularization by tissue perfusion parameters, such as, part of the plasma volume (Vp), plasma conversion constant (Ktrans) . But in the plaque tissue diffusion (DWI) characteristics of the study still have not reported. This project uses the DCE and DWI imaging technique to observe and measure on atherosclerosis model in progress . Tissue perfusion and diffusion parameters, pathologic specimens are analysis to clear the relationship between measurements and the corresponding organization pathological basis. Assessment the value of quantitative parameters in judgment of plaque vulnerability . More... »

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