Signal amplification effect of CC49 targeting molecular probe for PET imaging of colorectal cancer


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2018-2020

FUNDING AMOUNT

240000.0 CNY

ABSTRACT

Colorectal cancer shows high mortality due to its high recurrence, metastasis and difficulty in diagnosing on its early stage. PET imaging has the characteristics of high sensitivity and high resolution. However, for the early stage of colorectal cancer or small lesions, 18F-FDG PET often generates false positive results and lack of sensitivity.Therefore, it is urgent to develop new PET molecular probes with high specificity and sensitivity. Our preliminary results showed that the anti-CC49 has high affinity to CC49 receptors expressed in colorectal cancer cells. It’s also interesting to find that high tumor/non-tumor radioactivity ratios could be obtained with the using of pretargeting strategy. In this study, a novel amplification pretargeting approach will be applied, where a polymer with multiple copies of PNA is administered between injections of anti-CC49-cPNA and F-18 labeled cPNA, thus holds the potential to achieve a high tumor uptake and low background PET imaging of colorectal cancer. By virtue of this kind of method, accordingly, it will help to deliver an effective therapy to patients and improving survival rate. More... »

Related SciGraph Publications

  • 2022-05-06. Synthesis and in vivo evaluation of 18F-cPNA and Dendrimer-PNA conjugate for amplification pretargeting in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • 2022-04-22. Preliminary biological evaluation of rhenium-188-MAG3-PSMA in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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