Ontology type: schema:MonetaryGrant
2018-2020
FUNDING AMOUNT240000.0 CNY
ABSTRACTColorectal cancer shows high mortality due to its high recurrence, metastasis and difficulty in diagnosing on its early stage. PET imaging has the characteristics of high sensitivity and high resolution. However, for the early stage of colorectal cancer or small lesions, 18F-FDG PET often generates false positive results and lack of sensitivity.Therefore, it is urgent to develop new PET molecular probes with high specificity and sensitivity. Our preliminary results showed that the anti-CC49 has high affinity to CC49 receptors expressed in colorectal cancer cells. It’s also interesting to find that high tumor/non-tumor radioactivity ratios could be obtained with the using of pretargeting strategy. In this study, a novel amplification pretargeting approach will be applied, where a polymer with multiple copies of PNA is administered between injections of anti-CC49-cPNA and F-18 labeled cPNA, thus holds the potential to achieve a high tumor uptake and low background PET imaging of colorectal cancer. By virtue of this kind of method, accordingly, it will help to deliver an effective therapy to patients and improving survival rate. More... »
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