Biological Context View Homepage


Ontology type: schema:MonetaryGrant     


Grant Info

YEARS

2017-2020

FUNDING AMOUNT

5428424.0 GBP

ABSTRACT

The vast wealth of natural products discovered so far, and the far greater numbers predicted from genome sequences, potentially provide entirely new opportunities for biological discoveries. Many of these molecules are likely to have roles in the environment – for example in deterring or killing competitors, facilitating symbioses, acquiring nutrients, and attracting dispersal agents. By shedding light on the roles and targets of natural products and the contexts in which they are produced, we will provide new understanding of the biology of the producing organisms and the ecological niches they occupy and also accelerate the discovery of new bioactive molecules as antibiotics, therapeutics, agrichemicals, food ingredients and industrial raw materials. This research both draws on and feeds into product and pathway discovery research in the Project “Products and pathways”. Research in the Biological context Project stems in part from new discoveries in established areas of strength: bacterial growth and differentiation and the biology of proteins that are targets for antibiotics. The Project also takes a major new direction: the exploration of small-molecule interactions between microbes and other organisms in the soil. This is an area of strong synergy with other JIC research in Plant Health, and with the University of East Anglia. The outcomes of this Project are relevant for both the development and discovery of antibiotics and the search for new agrichemicals and interventions. Better understanding of the role of natural products in microbial interactions will underpin the identification of new antimicrobial molecules and biocontrol strains for the control of crop pests and diseases: a subject of particular concern given increasing legislative restrictions on the use of previously-allowed agrichemicals. More... »

URL

https://gtr.ukri.org/project/306D0C19-0F29-4F5A-9AF1-1BBE30F4B546

Related SciGraph Publications

  • 2021-09-01. Spatial rearrangement of the Streptomyces venezuelae linear chromosome during sporogenic development in NATURE COMMUNICATIONS
  • 2021-02-16. Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides in NATURE COMMUNICATIONS
  • 2020-05-13. Reproducible molecular networking of untargeted mass spectrometry data using GNPS in NATURE PROTOCOLS
  • 2020-04-06. Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal in NATURE MICROBIOLOGY
  • 2020-02-19. Teicoplanin biosynthesis: unraveling the interplay of structural, regulatory, and resistance genes in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2018-12-29. Oxytetracycline reduces the diversity of tetracycline-resistance genes in the Galleria mellonella gut microbiome in BMC MICROBIOLOGY
  • 2018-06-07. Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen in NATURE COMMUNICATIONS
  • 2018-03-19. The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development in NATURE COMMUNICATIONS
  • 2018-01-16. A rapid high-resolution method for resolving DNA topoisomers in BMC RESEARCH NOTES
  • 2017-12-06. Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors in NATURE COMMUNICATIONS
  • 2017-12-01. Antibiotic-resistant bacteria in the guts of insects feeding on plants: prospects for discovering plant-derived antibiotics in BMC MICROBIOLOGY
  • 2017-08-29. Galleria mellonella (greater wax moth) larvae as a model for antibiotic susceptibility testing and acute toxicity trials in BMC RESEARCH NOTES
  • 2017-06-26. An L-threonine transaldolase is required for L-threo-β-hydroxy-α-amino acid assembly during obafluorin biosynthesis in NATURE COMMUNICATIONS
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